FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2023202254> ?p ?o ?g. }

• W2023202254 endingPage "246" @default.
• W2023202254 startingPage "235" @default.
• W2023202254 abstract "We have previously reported the role of nitric oxide in colon tumor regression in vivo. The present study was designed to explore the influence of an endogenous nitric oxide donor, glyceryl trinitrate (GTN), on cell death pathways in colon cancer cells.Human colon cancer cell lines were treated with the NO donor GTN. Apoptosis was identified by morphological criteria and the terminal deoxynucleotidyl transferase-mediated deoxyuridine (TUNEL) method. The mitochondrial transmembrane potential was studied by flow cytometry, cytochrome c release by Western blot, and caspase activation by combining fluorogenic peptide substrates, peptide inhibitors, and immunoblotting. Expression of death receptors was studied by flow cytometry and confocal microscopy.GTN induces a dose- and time-dependent cell death by apoptosis in colon cancer cells. This cell death pathway involves the mitochondria and caspases, mainly caspase-1 and caspase-10. In contrast, caspase-3 activation is a late and limited event. Death receptors are not involved in GTN-mediated cell death, while GTN sensitizes tumor cells to Fas-ligand-induced apoptosis. This permissive effect correlates with an increased expression of Fas receptor and a decreased expression of several endogenous inhibitors of apoptosis (IAPs).Our results indicate that GTN (1) activates an unusual caspase cascade to induce apoptosis in colon cancer cells and (2) sensitizes these cells to Fas-mediated cell death by increasing the expression of Fas and decreasing the expression of several IAPs." @default.
• W2023202254 created "2016-06-24" @default.
• W2023202254 creator A5004873974 @default.
• W2023202254 creator A5010904728 @default.
• W2023202254 creator A5011660053 @default.
• W2023202254 creator A5023810956 @default.
• W2023202254 creator A5046859723 @default.
• W2023202254 creator A5071097123 @default.
• W2023202254 creator A5076385417 @default.
• W2023202254 creator A5091168690 @default.
• W2023202254 date "2002-07-01" @default.
• W2023202254 modified "2023-10-18" @default.
• W2023202254 title "Influence of the nitric oxide donor glyceryl trinitrate on apoptotic pathways in human colon cancer cells" @default.
• W2023202254 cites W125326105 @default.
• W2023202254 cites W1500396877 @default.
• W2023202254 cites W1572617528 @default.
• W2023202254 cites W1642763135 @default.
• W2023202254 cites W1834041853 @default.
• W2023202254 cites W1836073275 @default.
• W2023202254 cites W1964977785 @default.
• W2023202254 cites W1970408491 @default.
• W2023202254 cites W1970770376 @default.
• W2023202254 cites W1973018387 @default.
• W2023202254 cites W1992870310 @default.
• W2023202254 cites W1995306590 @default.
• W2023202254 cites W2000038822 @default.
• W2023202254 cites W2002503549 @default.
• W2023202254 cites W2004836763 @default.
• W2023202254 cites W2008261126 @default.
• W2023202254 cites W2009222624 @default.
• W2023202254 cites W2009627704 @default.
• W2023202254 cites W2015362281 @default.
• W2023202254 cites W2017728303 @default.
• W2023202254 cites W2021413266 @default.
• W2023202254 cites W2025044046 @default.
• W2023202254 cites W2041585650 @default.
• W2023202254 cites W2047571097 @default.
• W2023202254 cites W2049690056 @default.
• W2023202254 cites W2049740690 @default.
• W2023202254 cites W2057025197 @default.
• W2023202254 cites W2062445457 @default.
• W2023202254 cites W2062757512 @default.
• W2023202254 cites W2068147094 @default.
• W2023202254 cites W2072282073 @default.
• W2023202254 cites W2077705257 @default.
• W2023202254 cites W2083363077 @default.
• W2023202254 cites W2083906562 @default.
• W2023202254 cites W2084398452 @default.
• W2023202254 cites W2084509256 @default.
• W2023202254 cites W2087092800 @default.
• W2023202254 cites W2111181668 @default.
• W2023202254 cites W2117998622 @default.
• W2023202254 cites W2135662322 @default.
• W2023202254 cites W2154063020 @default.
• W2023202254 cites W2157999078 @default.
• W2023202254 cites W2159650080 @default.
• W2023202254 cites W2162172222 @default.
• W2023202254 cites W2162653594 @default.
• W2023202254 cites W2166710182 @default.
• W2023202254 cites W2167490100 @default.
• W2023202254 cites W2313663700 @default.
• W2023202254 cites W4313331914 @default.
• W2023202254 cites W74090958 @default.
• W2023202254 doi "https://doi.org/10.1053/gast.2002.34310" @default.
• W2023202254 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/12105852" @default.
• W2023202254 hasPublicationYear "2002" @default.
• W2023202254 type Work @default.
• W2023202254 sameAs 2023202254 @default.
• W2023202254 citedByCount "66" @default.
• W2023202254 countsByYear W20232022542012 @default.
• W2023202254 countsByYear W20232022542013 @default.
• W2023202254 countsByYear W20232022542014 @default.
• W2023202254 countsByYear W20232022542015 @default.
• W2023202254 countsByYear W20232022542016 @default.
• W2023202254 countsByYear W20232022542017 @default.
• W2023202254 countsByYear W20232022542018 @default.
• W2023202254 countsByYear W20232022542019 @default.
• W2023202254 countsByYear W20232022542020 @default.
• W2023202254 countsByYear W20232022542022 @default.
• W2023202254 countsByYear W20232022542023 @default.
• W2023202254 crossrefType "journal-article" @default.
• W2023202254 hasAuthorship W2023202254A5004873974 @default.
• W2023202254 hasAuthorship W2023202254A5010904728 @default.
• W2023202254 hasAuthorship W2023202254A5011660053 @default.
• W2023202254 hasAuthorship W2023202254A5023810956 @default.
• W2023202254 hasAuthorship W2023202254A5046859723 @default.
• W2023202254 hasAuthorship W2023202254A5071097123 @default.
• W2023202254 hasAuthorship W2023202254A5076385417 @default.
• W2023202254 hasAuthorship W2023202254A5091168690 @default.
• W2023202254 hasConcept C121608353 @default.
• W2023202254 hasConcept C134018914 @default.
• W2023202254 hasConcept C153911025 @default.
• W2023202254 hasConcept C163421366 @default.
• W2023202254 hasConcept C181199279 @default.
• W2023202254 hasConcept C182979987 @default.
• W2023202254 hasConcept C185592680 @default.
• W2023202254 hasConcept C190283241 @default.
• W2023202254 hasConcept C196795494 @default.

• next