Matches in SemOpenAlex for { <https://semopenalex.org/work/W2023202354> ?p ?o ?g. }
Showing items 1 to 90 of
90
with 100 items per page.
- W2023202354 endingPage "2733" @default.
- W2023202354 startingPage "2727" @default.
- W2023202354 abstract "2-Biphenylol, 3-biphenylol, 2,2'-biphenyldiol, 3,3'-biphenyldiol, 3-chloro-2-biphenylol, and 4,4'-dichloro-3-biphenylol were evaluated using the scrape-loading/dye transfer (SL/ DT) technique to determine in vitro gap junctional intercellular communication (GJIC) in a normal rat liver epithelial cell line as a measure of the epigenetic toxicity. Cytotoxicity was determined using the neutral red uptake assay. A dose range of 0-300 microM was examined. Only 3,3'-biphenyldiol and 4,4'-dichloro-3-biphenylol induced cytotoxicity within the tested dose ranges. Noncytotoxic doses were selected for evaluation of epigenetic toxicity. 4,4'-Dichloro-3-biphenylol was most inhibitory to GJIC at the lowest dose. The cytotoxicity and GJIC inhibitory effects observed for 4,4'-dichloro-3-biphenylol might be, although not exclusively, a consequence of the lipophilic nature of this chemical. 3-Chloro-2-biphenylol was least inhibitory to GJIC. 3-Chloro-2-biphenylol was less inhibitory to GJIC than 2-biphenylol because of the presence of the chlorine functional group, which appears to attenuate the toxic effect of the ortho-hydroxyl group. Although cells were capable of complete recovery of GJIC after removal of each of the chemicals, only with 2,2'-biphenyldiol and 4,4,'-dichloro-3-biphenylol did the cells demonstrate partial recovery without removal of the chemical. The more noncoplanar conformation of 2,2'-biphenyldiol and 2-biphenylol might explain their more inhibitory behavior in comparison to 3,3'-biphenyldiol and 3-biphenylol, respectively." @default.
- W2023202354 created "2016-06-24" @default.
- W2023202354 creator A5001846206 @default.
- W2023202354 creator A5019681249 @default.
- W2023202354 creator A5041576594 @default.
- W2023202354 date "2003-05-07" @default.
- W2023202354 modified "2023-09-23" @default.
- W2023202354 title "Epigenetic Toxicity of Hydroxylated Biphenyls and Hydroxylated Polychlorinated Biphenyls on Normal Rat Liver Epithelial Cells" @default.
- W2023202354 cites W1971509668 @default.
- W2023202354 cites W1992919597 @default.
- W2023202354 cites W1996009175 @default.
- W2023202354 cites W2001326655 @default.
- W2023202354 cites W2002406723 @default.
- W2023202354 cites W2012966220 @default.
- W2023202354 cites W2071590225 @default.
- W2023202354 cites W2076907968 @default.
- W2023202354 cites W2088686339 @default.
- W2023202354 cites W2089269257 @default.
- W2023202354 cites W2094170116 @default.
- W2023202354 cites W2109699277 @default.
- W2023202354 cites W2147434352 @default.
- W2023202354 cites W2150224103 @default.
- W2023202354 cites W4256088045 @default.
- W2023202354 doi "https://doi.org/10.1021/es021041t" @default.
- W2023202354 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/12854712" @default.
- W2023202354 hasPublicationYear "2003" @default.
- W2023202354 type Work @default.
- W2023202354 sameAs 2023202354 @default.
- W2023202354 citedByCount "7" @default.
- W2023202354 countsByYear W20232023542012 @default.
- W2023202354 countsByYear W20232023542013 @default.
- W2023202354 countsByYear W20232023542014 @default.
- W2023202354 countsByYear W20232023542017 @default.
- W2023202354 countsByYear W20232023542021 @default.
- W2023202354 crossrefType "journal-article" @default.
- W2023202354 hasAuthorship W2023202354A5001846206 @default.
- W2023202354 hasAuthorship W2023202354A5019681249 @default.
- W2023202354 hasAuthorship W2023202354A5041576594 @default.
- W2023202354 hasConcept C109316439 @default.
- W2023202354 hasConcept C134018914 @default.
- W2023202354 hasConcept C17077164 @default.
- W2023202354 hasConcept C178790620 @default.
- W2023202354 hasConcept C185592680 @default.
- W2023202354 hasConcept C202751555 @default.
- W2023202354 hasConcept C29730261 @default.
- W2023202354 hasConcept C505241676 @default.
- W2023202354 hasConcept C54355233 @default.
- W2023202354 hasConcept C55493867 @default.
- W2023202354 hasConcept C71240020 @default.
- W2023202354 hasConcept C79879829 @default.
- W2023202354 hasConcept C81885089 @default.
- W2023202354 hasConcept C86803240 @default.
- W2023202354 hasConcept C98274493 @default.
- W2023202354 hasConceptScore W2023202354C109316439 @default.
- W2023202354 hasConceptScore W2023202354C134018914 @default.
- W2023202354 hasConceptScore W2023202354C17077164 @default.
- W2023202354 hasConceptScore W2023202354C178790620 @default.
- W2023202354 hasConceptScore W2023202354C185592680 @default.
- W2023202354 hasConceptScore W2023202354C202751555 @default.
- W2023202354 hasConceptScore W2023202354C29730261 @default.
- W2023202354 hasConceptScore W2023202354C505241676 @default.
- W2023202354 hasConceptScore W2023202354C54355233 @default.
- W2023202354 hasConceptScore W2023202354C55493867 @default.
- W2023202354 hasConceptScore W2023202354C71240020 @default.
- W2023202354 hasConceptScore W2023202354C79879829 @default.
- W2023202354 hasConceptScore W2023202354C81885089 @default.
- W2023202354 hasConceptScore W2023202354C86803240 @default.
- W2023202354 hasConceptScore W2023202354C98274493 @default.
- W2023202354 hasIssue "12" @default.
- W2023202354 hasLocation W20232023541 @default.
- W2023202354 hasLocation W20232023542 @default.
- W2023202354 hasOpenAccess W2023202354 @default.
- W2023202354 hasPrimaryLocation W20232023541 @default.
- W2023202354 hasRelatedWork W1975904626 @default.
- W2023202354 hasRelatedWork W1986945018 @default.
- W2023202354 hasRelatedWork W1996374427 @default.
- W2023202354 hasRelatedWork W1999272804 @default.
- W2023202354 hasRelatedWork W2008038590 @default.
- W2023202354 hasRelatedWork W2035450482 @default.
- W2023202354 hasRelatedWork W2317814092 @default.
- W2023202354 hasRelatedWork W2464301138 @default.
- W2023202354 hasRelatedWork W2994071189 @default.
- W2023202354 hasRelatedWork W4224130633 @default.
- W2023202354 hasVolume "37" @default.
- W2023202354 isParatext "false" @default.
- W2023202354 isRetracted "false" @default.
- W2023202354 magId "2023202354" @default.
- W2023202354 workType "article" @default.