Matches in SemOpenAlex for { <https://semopenalex.org/work/W2023203244> ?p ?o ?g. }
- W2023203244 endingPage "25" @default.
- W2023203244 startingPage "17" @default.
- W2023203244 abstract "Calorie restriction (CR), which is thought to be largely dependent on the neuroendocrine system modulated by insulin/insulin-like growth factor-I (IGF-I) and leptin signaling, decreases morbidity and increases lifespan in many organisms. To elucidate whether insulin and leptin sensitivities are indispensable in the metabolic adaptation to CR, we investigated the effects of CR on obese Zucker (fa/fa) rats and lean control (+/+) rats. CR did not fully improve insulin resistance in (fa/fa) rats. Nonetheless, CR induced neuropeptide Y (NPY) expression in the hypothalamic arcuate nucleus and metabolism related gene expression changes in the liver in (fa/fa) rats and (+/+) rats. Up-regulation of NPY augmented plasma corticosterone levels and suppressed pituitary growth hormone (GH) expression, thereby modulating adipocytokine production to induce tissue-specific insulin sensitivity. Thus, central NPY activation via peripheral signaling might play a crucial role in the effects of CR, even in insulin resistant and leptin receptor deficient conditions." @default.
- W2023203244 created "2016-06-24" @default.
- W2023203244 creator A5003879012 @default.
- W2023203244 creator A5004864085 @default.
- W2023203244 creator A5024916991 @default.
- W2023203244 creator A5041815199 @default.
- W2023203244 creator A5045374871 @default.
- W2023203244 creator A5054276404 @default.
- W2023203244 creator A5055319770 @default.
- W2023203244 creator A5055431201 @default.
- W2023203244 creator A5063082133 @default.
- W2023203244 date "2009-10-15" @default.
- W2023203244 modified "2023-09-26" @default.
- W2023203244 title "Similar metabolic responses to calorie restriction in lean and obese Zucker rats" @default.
- W2023203244 cites W1521853181 @default.
- W2023203244 cites W1561443084 @default.
- W2023203244 cites W1603786143 @default.
- W2023203244 cites W1616806865 @default.
- W2023203244 cites W1967267087 @default.
- W2023203244 cites W1984036757 @default.
- W2023203244 cites W1989120105 @default.
- W2023203244 cites W2002294810 @default.
- W2023203244 cites W2009932749 @default.
- W2023203244 cites W2012149716 @default.
- W2023203244 cites W2019152336 @default.
- W2023203244 cites W2026954718 @default.
- W2023203244 cites W2027976521 @default.
- W2023203244 cites W2034477294 @default.
- W2023203244 cites W204690133 @default.
- W2023203244 cites W2047683380 @default.
- W2023203244 cites W2049652810 @default.
- W2023203244 cites W2049842278 @default.
- W2023203244 cites W2052722944 @default.
- W2023203244 cites W2053176849 @default.
- W2023203244 cites W2056089140 @default.
- W2023203244 cites W2056673369 @default.
- W2023203244 cites W2061286916 @default.
- W2023203244 cites W2064925928 @default.
- W2023203244 cites W2066283353 @default.
- W2023203244 cites W2072780035 @default.
- W2023203244 cites W2073372597 @default.
- W2023203244 cites W2087393295 @default.
- W2023203244 cites W2087761054 @default.
- W2023203244 cites W2089018784 @default.
- W2023203244 cites W2092770006 @default.
- W2023203244 cites W2100631033 @default.
- W2023203244 cites W2100835249 @default.
- W2023203244 cites W2121154706 @default.
- W2023203244 cites W2123706177 @default.
- W2023203244 cites W2125914461 @default.
- W2023203244 cites W2126027530 @default.
- W2023203244 cites W2126796697 @default.
- W2023203244 cites W2131872615 @default.
- W2023203244 cites W2134100055 @default.
- W2023203244 cites W2157263986 @default.
- W2023203244 cites W2161239116 @default.
- W2023203244 cites W2161637152 @default.
- W2023203244 cites W2162275830 @default.
- W2023203244 cites W2166798057 @default.
- W2023203244 cites W2170344274 @default.
- W2023203244 cites W2171667805 @default.
- W2023203244 cites W2321527267 @default.
- W2023203244 cites W2469269412 @default.
- W2023203244 doi "https://doi.org/10.1016/j.mce.2009.05.001" @default.
- W2023203244 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/19446600" @default.
- W2023203244 hasPublicationYear "2009" @default.
- W2023203244 type Work @default.
- W2023203244 sameAs 2023203244 @default.
- W2023203244 citedByCount "31" @default.
- W2023203244 countsByYear W20232032442012 @default.
- W2023203244 countsByYear W20232032442013 @default.
- W2023203244 countsByYear W20232032442014 @default.
- W2023203244 countsByYear W20232032442015 @default.
- W2023203244 countsByYear W20232032442017 @default.
- W2023203244 countsByYear W20232032442018 @default.
- W2023203244 countsByYear W20232032442019 @default.
- W2023203244 countsByYear W20232032442020 @default.
- W2023203244 countsByYear W20232032442021 @default.
- W2023203244 crossrefType "journal-article" @default.
- W2023203244 hasAuthorship W2023203244A5003879012 @default.
- W2023203244 hasAuthorship W2023203244A5004864085 @default.
- W2023203244 hasAuthorship W2023203244A5024916991 @default.
- W2023203244 hasAuthorship W2023203244A5041815199 @default.
- W2023203244 hasAuthorship W2023203244A5045374871 @default.
- W2023203244 hasAuthorship W2023203244A5054276404 @default.
- W2023203244 hasAuthorship W2023203244A5055319770 @default.
- W2023203244 hasAuthorship W2023203244A5055431201 @default.
- W2023203244 hasAuthorship W2023203244A5063082133 @default.
- W2023203244 hasConcept C112446052 @default.
- W2023203244 hasConcept C118303440 @default.
- W2023203244 hasConcept C126322002 @default.
- W2023203244 hasConcept C134018914 @default.
- W2023203244 hasConcept C14372207 @default.
- W2023203244 hasConcept C170493617 @default.
- W2023203244 hasConcept C2777391703 @default.
- W2023203244 hasConcept C2778707264 @default.
- W2023203244 hasConcept C2779306644 @default.
- W2023203244 hasConcept C2780352252 @default.