FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2023203816> ?p ?o ?g. }

• W2023203816 endingPage "264" @default.
• W2023203816 startingPage "251" @default.
• W2023203816 abstract "Cisplatin, a widely used anticancer drug, produces significant oto- and nephrotoxicity. Previous data from our laboratory, using cultured cell lines, indicated that cisplatin increases the expression of the adenosine A(1) receptor subtype through generation of reactive oxygen species and activation of nuclear factor-kappa B (NF-kappa B). Since the adenosine A(1) receptor plays an important role in normal renal physiology, this study was performed to determine whether cisplatin modulates adenosine A(1) receptor expression in vivo and whether these receptors play a role in the nephrotoxicity. Male Sprague-Dawley rats, treated with cisplatin (8 mg/kg), developed nephrotoxicity within 3 days, as demonstrated by increased serum creatinine and blood urea nitrogen. Cisplatin also produced a significant increase in malondialdehyde, apoptosis and necrosis in the kidney. The above changes were associated with a time-dependent increase in the expression of adenosine A(1) receptor, as determined by radioligand binding assays, Western blotting and immunocytochemistry, and an increase in adenosine A(1) receptor transcripts. Administration of selective and nonselective antagonists of the adenosine A(1) receptor produced either no change or exacerbated the nephrotoxicity produced by cisplatin. These data indicate that cisplatin can regulate the adenosine A(1) receptor in the kidney and suggest a cytoprotective role of this receptor subtype against cisplatin-induced nephrotoxicity." @default.
• W2023203816 created "2016-06-24" @default.
• W2023203816 creator A5002987740 @default.
• W2023203816 creator A5018988033 @default.
• W2023203816 creator A5025412162 @default.
• W2023203816 creator A5052036878 @default.
• W2023203816 creator A5059572673 @default.
• W2023203816 creator A5062088552 @default.
• W2023203816 creator A5071609521 @default.
• W2023203816 date "2002-05-01" @default.
• W2023203816 modified "2023-09-27" @default.
• W2023203816 title "Cisplatin up-regulates the adenosine A1 receptor in the rat kidney" @default.
• W2023203816 cites W1505626165 @default.
• W2023203816 cites W1546592314 @default.
• W2023203816 cites W1750690213 @default.
• W2023203816 cites W1802274669 @default.
• W2023203816 cites W1808088816 @default.
• W2023203816 cites W191793640 @default.
• W2023203816 cites W1963718159 @default.
• W2023203816 cites W1964088747 @default.
• W2023203816 cites W1965916534 @default.
• W2023203816 cites W1970701690 @default.
• W2023203816 cites W1973509668 @default.
• W2023203816 cites W1978690847 @default.
• W2023203816 cites W1978815983 @default.
• W2023203816 cites W1983310681 @default.
• W2023203816 cites W1983565936 @default.
• W2023203816 cites W1996202908 @default.
• W2023203816 cites W1996680733 @default.
• W2023203816 cites W2024330234 @default.
• W2023203816 cites W2040852689 @default.
• W2023203816 cites W2041480674 @default.
• W2023203816 cites W2046572180 @default.
• W2023203816 cites W2056569797 @default.
• W2023203816 cites W2058285926 @default.
• W2023203816 cites W2061257143 @default.
• W2023203816 cites W2066820242 @default.
• W2023203816 cites W2068889913 @default.
• W2023203816 cites W2073476025 @default.
• W2023203816 cites W2076972259 @default.
• W2023203816 cites W2079163151 @default.
• W2023203816 cites W2084839593 @default.
• W2023203816 cites W2098300251 @default.
• W2023203816 cites W2098797278 @default.
• W2023203816 cites W2121930621 @default.
• W2023203816 cites W2137421038 @default.
• W2023203816 cites W2140639013 @default.
• W2023203816 cites W2160321809 @default.
• W2023203816 cites W2262733167 @default.
• W2023203816 cites W2329860857 @default.
• W2023203816 cites W2465927728 @default.
• W2023203816 cites W4235085682 @default.
• W2023203816 cites W67746198 @default.
• W2023203816 doi "https://doi.org/10.1016/s0014-2999(02)01510-8" @default.
• W2023203816 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/12065079" @default.
• W2023203816 hasPublicationYear "2002" @default.
• W2023203816 type Work @default.
• W2023203816 sameAs 2023203816 @default.
• W2023203816 citedByCount "29" @default.
• W2023203816 countsByYear W20232038162013 @default.
• W2023203816 countsByYear W20232038162014 @default.
• W2023203816 countsByYear W20232038162016 @default.
• W2023203816 countsByYear W20232038162017 @default.
• W2023203816 countsByYear W20232038162019 @default.
• W2023203816 countsByYear W20232038162020 @default.
• W2023203816 countsByYear W20232038162021 @default.
• W2023203816 crossrefType "journal-article" @default.
• W2023203816 hasAuthorship W2023203816A5002987740 @default.
• W2023203816 hasAuthorship W2023203816A5018988033 @default.
• W2023203816 hasAuthorship W2023203816A5025412162 @default.
• W2023203816 hasAuthorship W2023203816A5052036878 @default.
• W2023203816 hasAuthorship W2023203816A5059572673 @default.
• W2023203816 hasAuthorship W2023203816A5062088552 @default.
• W2023203816 hasAuthorship W2023203816A5071609521 @default.
• W2023203816 hasConcept C126189478 @default.
• W2023203816 hasConcept C126322002 @default.
• W2023203816 hasConcept C134018914 @default.
• W2023203816 hasConcept C158424129 @default.
• W2023203816 hasConcept C170493617 @default.
• W2023203816 hasConcept C172590197 @default.
• W2023203816 hasConcept C182683403 @default.
• W2023203816 hasConcept C185592680 @default.
• W2023203816 hasConcept C2776694085 @default.
• W2023203816 hasConcept C2776991684 @default.
• W2023203816 hasConcept C2778239845 @default.
• W2023203816 hasConcept C2778938600 @default.
• W2023203816 hasConcept C2780091579 @default.
• W2023203816 hasConcept C67907053 @default.
• W2023203816 hasConcept C71924100 @default.
• W2023203816 hasConcept C86803240 @default.
• W2023203816 hasConcept C98274493 @default.
• W2023203816 hasConceptScore W2023203816C126189478 @default.
• W2023203816 hasConceptScore W2023203816C126322002 @default.
• W2023203816 hasConceptScore W2023203816C134018914 @default.
• W2023203816 hasConceptScore W2023203816C158424129 @default.
• W2023203816 hasConceptScore W2023203816C170493617 @default.
• W2023203816 hasConceptScore W2023203816C172590197 @default.
• W2023203816 hasConceptScore W2023203816C182683403 @default.

• next