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- W2023204807 abstract "AbstractWe investigated whether coexposure to inhaled ambient particles and ozone affects airway responsiveness (AR, measured as enhanced pause, Penh) and allergic inflammation (AI) in a murine model of asthma. Ovalbumin-sensitized mice were challenged with either ovalbumin (asthmatic) or phosphate-buffered saline (PBS) aerosols for 3 successive days. Immediately after daily challenge, mice were exposed for 5 h to concentrated ambient particles (CAPs), or 0.3 ppm ozone, or both, or neither (n ≥ 61/group, 12 experiments). Exposure to CAPs alone or coexposure to CAPs + O 3 caused an increase in Penh in both normal and asthmatic mice. These responses were transient and small, increasing approximately 0.9% per 100-µg/m 3 increase in CAPs. Analysis of the effects of particle composition on AR revealed an association between the AlSi particle fraction and increased AR in asthmatic mice exposed to ozone and particles. No effects of pollutants on AI were noted. We conclude that (1) particle exposure causes an immediate, short-lived (<24 h) increase in AR in mice; (2) these responses are small; and (3) changes in AR may be correlated with specific elements within the particle mixture." @default.
- W2023204807 created "2016-06-24" @default.
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- W2023204807 date "2002-01-01" @default.
- W2023204807 modified "2023-09-26" @default.
- W2023204807 title "COMBINED AIR POLLUTION PARTICLE AND OZONE EXPOSURE INCREASES AIRWAY RESPONSIVENESS IN MICE" @default.
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- W2023204807 doi "https://doi.org/10.1080/08958370252870989" @default.
- W2023204807 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/12028808" @default.