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- W2023205056 abstract "Abstract Objective: We compared the impact of Lispro insulin on Hb A1C and birth weight (BW) with the impact of standard insulin. Study design: Patients with pregestational or gestational diabetes who needed insulin before 20 weeks in pregnancy were evaluated. Patients with iatrogenic preterm delivery were excluded. Demographic and clinical data were collected, including Hb A1Cfrom each trimester and BW percentiles (BW%). The Hb A1Clevels and BW% of Lispro (Group 1) and standard insulin (Group 2) were compared using the Mann-Whitney U test for continuous variables and Fisher’s exact test for categorical variables. Results: Fifty patients were evaluated (Group 1 = 21, Group 2 = 29). There were no significant differences in demographics. Group 1 Group 2 P Hb A1C 1st trimester 8.04 ± 1.74 9.24 ± 2.14 NS Hb A1C 2nd trimester 7.28 ± 1.74 7.57 ± 1.44 NS Hb A1C 3rd trimester 6.95 ± 1.51 7.5 ± 1.27 NS GA (weeks) 36.7 ± 1.4 36.7 ± 1.6 NS BW >90% 1/21 (4.8%) 6/29 (20.7%) 0.051 C/S 13/21 (61.9%) 17/29 (58.6%) NS Conclusions: Lispro does not appear to improve blood glucose control as represented by Hb A1C levels. There is a trend toward less macrosomia with Lispro. Further study is needed to determine whether Lispro improves perinatal outcomes." @default.
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- W2023205056 date "2001-05-01" @default.
- W2023205056 modified "2023-09-25" @default.
- W2023205056 title "Does lispro improve blood glucose control and birth weight?" @default.
- W2023205056 doi "https://doi.org/10.1016/s0029-7844(01)01241-8" @default.
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