Matches in SemOpenAlex for { <https://semopenalex.org/work/W2023206012> ?p ?o ?g. }
Showing items 1 to 95 of
95
with 100 items per page.
- W2023206012 endingPage "4523" @default.
- W2023206012 startingPage "4517" @default.
- W2023206012 abstract "The N-terminal proline-rich domain of human p53 has been shown to be important for the induction of apoptosis. However, the corresponding region in mouse and other species is not highly conserved and has been less well studied. In this paper, we have characterized mutants with deletions in this region of mouse p53. Our results demonstrate that deletions in the proline-rich domain have varying effects on function ranging from no effect to severe impairment of cell death activity, depending on precisely which residues are deleted. We also show that the mutants differ in their ability to transactivate different p53 target promoters. Although we have been able to obtain mutants selectively impaired for apoptosis, our data are not generally consistent with this region being a functional domain. The data are more consistent with the interpretation that the region influences function by altering local protein structure which may affect promoter discrimination." @default.
- W2023206012 created "2016-06-24" @default.
- W2023206012 creator A5002533734 @default.
- W2023206012 creator A5029629862 @default.
- W2023206012 creator A5029823099 @default.
- W2023206012 creator A5039647358 @default.
- W2023206012 creator A5090852800 @default.
- W2023206012 date "2003-07-17" @default.
- W2023206012 modified "2023-09-26" @default.
- W2023206012 title "The proline-rich region of mouse p53 influences transactivation and apoptosis but is largely dispensable for these functions" @default.
- W2023206012 cites W1967448808 @default.
- W2023206012 cites W1983171715 @default.
- W2023206012 cites W1984755213 @default.
- W2023206012 cites W1992760686 @default.
- W2023206012 cites W1997388033 @default.
- W2023206012 cites W2000823493 @default.
- W2023206012 cites W2029529223 @default.
- W2023206012 cites W2043107604 @default.
- W2023206012 cites W2050269111 @default.
- W2023206012 cites W2065643866 @default.
- W2023206012 cites W2074114480 @default.
- W2023206012 cites W2074451679 @default.
- W2023206012 cites W2080704341 @default.
- W2023206012 cites W2109328121 @default.
- W2023206012 cites W2129905922 @default.
- W2023206012 cites W2131989828 @default.
- W2023206012 cites W2136545880 @default.
- W2023206012 cites W2163470365 @default.
- W2023206012 cites W2324799005 @default.
- W2023206012 cites W2332512755 @default.
- W2023206012 cites W4241106723 @default.
- W2023206012 doi "https://doi.org/10.1038/sj.onc.1206726" @default.
- W2023206012 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/12881708" @default.
- W2023206012 hasPublicationYear "2003" @default.
- W2023206012 type Work @default.
- W2023206012 sameAs 2023206012 @default.
- W2023206012 citedByCount "26" @default.
- W2023206012 countsByYear W20232060122012 @default.
- W2023206012 countsByYear W20232060122013 @default.
- W2023206012 countsByYear W20232060122014 @default.
- W2023206012 countsByYear W20232060122015 @default.
- W2023206012 countsByYear W20232060122017 @default.
- W2023206012 countsByYear W20232060122018 @default.
- W2023206012 countsByYear W20232060122019 @default.
- W2023206012 crossrefType "journal-article" @default.
- W2023206012 hasAuthorship W2023206012A5002533734 @default.
- W2023206012 hasAuthorship W2023206012A5029629862 @default.
- W2023206012 hasAuthorship W2023206012A5029823099 @default.
- W2023206012 hasAuthorship W2023206012A5039647358 @default.
- W2023206012 hasAuthorship W2023206012A5090852800 @default.
- W2023206012 hasBestOaLocation W20232060121 @default.
- W2023206012 hasConcept C104317684 @default.
- W2023206012 hasConcept C1292079 @default.
- W2023206012 hasConcept C14036430 @default.
- W2023206012 hasConcept C143065580 @default.
- W2023206012 hasConcept C190283241 @default.
- W2023206012 hasConcept C2779815552 @default.
- W2023206012 hasConcept C515207424 @default.
- W2023206012 hasConcept C54355233 @default.
- W2023206012 hasConcept C86339819 @default.
- W2023206012 hasConcept C86803240 @default.
- W2023206012 hasConcept C95444343 @default.
- W2023206012 hasConceptScore W2023206012C104317684 @default.
- W2023206012 hasConceptScore W2023206012C1292079 @default.
- W2023206012 hasConceptScore W2023206012C14036430 @default.
- W2023206012 hasConceptScore W2023206012C143065580 @default.
- W2023206012 hasConceptScore W2023206012C190283241 @default.
- W2023206012 hasConceptScore W2023206012C2779815552 @default.
- W2023206012 hasConceptScore W2023206012C515207424 @default.
- W2023206012 hasConceptScore W2023206012C54355233 @default.
- W2023206012 hasConceptScore W2023206012C86339819 @default.
- W2023206012 hasConceptScore W2023206012C86803240 @default.
- W2023206012 hasConceptScore W2023206012C95444343 @default.
- W2023206012 hasIssue "29" @default.
- W2023206012 hasLocation W20232060121 @default.
- W2023206012 hasLocation W20232060122 @default.
- W2023206012 hasOpenAccess W2023206012 @default.
- W2023206012 hasPrimaryLocation W20232060121 @default.
- W2023206012 hasRelatedWork W1543358981 @default.
- W2023206012 hasRelatedWork W1927421238 @default.
- W2023206012 hasRelatedWork W1983725845 @default.
- W2023206012 hasRelatedWork W2009416280 @default.
- W2023206012 hasRelatedWork W2011292993 @default.
- W2023206012 hasRelatedWork W2101920100 @default.
- W2023206012 hasRelatedWork W2111311526 @default.
- W2023206012 hasRelatedWork W2111958127 @default.
- W2023206012 hasRelatedWork W2117110650 @default.
- W2023206012 hasRelatedWork W2140441397 @default.
- W2023206012 hasVolume "22" @default.
- W2023206012 isParatext "false" @default.
- W2023206012 isRetracted "false" @default.
- W2023206012 magId "2023206012" @default.
- W2023206012 workType "article" @default.