Matches in SemOpenAlex for { <https://semopenalex.org/work/W2023207836> ?p ?o ?g. }
Showing items 1 to 100 of
100
with 100 items per page.
- W2023207836 endingPage "467" @default.
- W2023207836 startingPage "462" @default.
- W2023207836 abstract "The stability of p21(WAF1) and p53 is increased by UV radiation or proteasome inhibitors in normal and some tumor cells. However, p21(WAF1) can either stimulate in vitro assembly of active cyclin-kinase complexes at low concentrations or inhibit this activity at high concentrations. Also, ectopic p21(WAF1) over-expression has been reported to promote or suppress apoptosis, depending on the target cells. We have investigated changes in p21(WAF1) expression as a result of exposure to either 25 J/m(2) UV or 10 microM MG-115 proteasome inhibitor, both of which cause apoptosis in human C8161 melanoma cells. p21(WAF1) mRNA increased in response to UV irradiation but failed to accumulate at the protein level because of its early UV-activated degradation counteracted by proteasome inhibition. UV-mediated loss of p21(WAF1) protein preceding induction of p53 and cell death was greater in non-metastatic than in metastatic C8161 melanoma cells. No loss in p21(WAF1) occurred with apoptosis induced by 10 microM proteasome inhibitors MG-115 or lactacystin, mediated by over-expression of p21(WAF1). Our results suggest that conditions causing prolonged or permanent changes in basal levels of p21(WAF1) may impair its reversible cell-cycle checkpoint function, leading to irreversible growth arrest or cell death." @default.
- W2023207836 created "2016-06-24" @default.
- W2023207836 creator A5026515035 @default.
- W2023207836 date "2000-05-15" @default.
- W2023207836 modified "2023-10-09" @default.
- W2023207836 title "Apoptosis-inducing levels of uv radiation and proteasome inhibitors produce opposite effects on p21WAF1 in human melanoma cells" @default.
- W2023207836 cites W1969385456 @default.
- W2023207836 cites W1972233897 @default.
- W2023207836 cites W1975277514 @default.
- W2023207836 cites W1975945227 @default.
- W2023207836 cites W1976112378 @default.
- W2023207836 cites W1977012301 @default.
- W2023207836 cites W1992360356 @default.
- W2023207836 cites W2008506563 @default.
- W2023207836 cites W2015519364 @default.
- W2023207836 cites W2022218364 @default.
- W2023207836 cites W2032881748 @default.
- W2023207836 cites W2053648381 @default.
- W2023207836 cites W2054695113 @default.
- W2023207836 cites W2056769035 @default.
- W2023207836 cites W2070061120 @default.
- W2023207836 cites W2071191421 @default.
- W2023207836 cites W2071985423 @default.
- W2023207836 cites W2085485098 @default.
- W2023207836 cites W2086756954 @default.
- W2023207836 cites W2121942598 @default.
- W2023207836 cites W2147887491 @default.
- W2023207836 cites W2151160119 @default.
- W2023207836 cites W2166529745 @default.
- W2023207836 cites W2170027768 @default.
- W2023207836 cites W4231239803 @default.
- W2023207836 doi "https://doi.org/10.1002/(sici)1097-0215(20000515)86:4<462::aid-ijc3>3.0.co;2-b" @default.
- W2023207836 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/10797256" @default.
- W2023207836 hasPublicationYear "2000" @default.
- W2023207836 type Work @default.
- W2023207836 sameAs 2023207836 @default.
- W2023207836 citedByCount "23" @default.
- W2023207836 countsByYear W20232078362013 @default.
- W2023207836 countsByYear W20232078362015 @default.
- W2023207836 countsByYear W20232078362016 @default.
- W2023207836 crossrefType "journal-article" @default.
- W2023207836 hasAuthorship W2023207836A5026515035 @default.
- W2023207836 hasConcept C184235292 @default.
- W2023207836 hasConcept C190283241 @default.
- W2023207836 hasConcept C202751555 @default.
- W2023207836 hasConcept C27740335 @default.
- W2023207836 hasConcept C2776148510 @default.
- W2023207836 hasConcept C2777658100 @default.
- W2023207836 hasConcept C2778367456 @default.
- W2023207836 hasConcept C29537977 @default.
- W2023207836 hasConcept C31573885 @default.
- W2023207836 hasConcept C502942594 @default.
- W2023207836 hasConcept C54355233 @default.
- W2023207836 hasConcept C55493867 @default.
- W2023207836 hasConcept C56483683 @default.
- W2023207836 hasConcept C81885089 @default.
- W2023207836 hasConcept C86803240 @default.
- W2023207836 hasConcept C95444343 @default.
- W2023207836 hasConcept C97037327 @default.
- W2023207836 hasConcept C98424977 @default.
- W2023207836 hasConceptScore W2023207836C184235292 @default.
- W2023207836 hasConceptScore W2023207836C190283241 @default.
- W2023207836 hasConceptScore W2023207836C202751555 @default.
- W2023207836 hasConceptScore W2023207836C27740335 @default.
- W2023207836 hasConceptScore W2023207836C2776148510 @default.
- W2023207836 hasConceptScore W2023207836C2777658100 @default.
- W2023207836 hasConceptScore W2023207836C2778367456 @default.
- W2023207836 hasConceptScore W2023207836C29537977 @default.
- W2023207836 hasConceptScore W2023207836C31573885 @default.
- W2023207836 hasConceptScore W2023207836C502942594 @default.
- W2023207836 hasConceptScore W2023207836C54355233 @default.
- W2023207836 hasConceptScore W2023207836C55493867 @default.
- W2023207836 hasConceptScore W2023207836C56483683 @default.
- W2023207836 hasConceptScore W2023207836C81885089 @default.
- W2023207836 hasConceptScore W2023207836C86803240 @default.
- W2023207836 hasConceptScore W2023207836C95444343 @default.
- W2023207836 hasConceptScore W2023207836C97037327 @default.
- W2023207836 hasConceptScore W2023207836C98424977 @default.
- W2023207836 hasIssue "4" @default.
- W2023207836 hasLocation W20232078361 @default.
- W2023207836 hasLocation W20232078362 @default.
- W2023207836 hasOpenAccess W2023207836 @default.
- W2023207836 hasPrimaryLocation W20232078361 @default.
- W2023207836 hasRelatedWork W1972489358 @default.
- W2023207836 hasRelatedWork W2014888545 @default.
- W2023207836 hasRelatedWork W2099130307 @default.
- W2023207836 hasRelatedWork W2114307219 @default.
- W2023207836 hasRelatedWork W2132427641 @default.
- W2023207836 hasRelatedWork W234617279 @default.
- W2023207836 hasRelatedWork W2360552219 @default.
- W2023207836 hasRelatedWork W3022694556 @default.
- W2023207836 hasRelatedWork W4230809382 @default.
- W2023207836 hasRelatedWork W2741146868 @default.
- W2023207836 hasVolume "86" @default.
- W2023207836 isParatext "false" @default.
- W2023207836 isRetracted "false" @default.
- W2023207836 magId "2023207836" @default.
- W2023207836 workType "article" @default.