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- W2023209107 abstract "Objective: Most studies have found survival after local recurrence of breast cancer to be poorer after mastectomy than after breast-conserving surgery. We studied whether this is the case because patients undergoing mastectomy have a more unfavorable risk profile and whether it applies also to patients with early stage disease. Methods: We conducted a matched-pair analysis (breast-conserving surgery vs. mastectomy) of 62 patients with local recurrence of early stage (pT1 -pT2 NO) breast cancer without evidence of systemic disease. Patients were matched for tumor size, histologic grade and age. Prognostic parameters at the time of primary diagnosis and at recurrence were evaluated with univariate and multivariate analyses with respect to survival after recurrence. The median follow-up was 7.5 years. Results: There were no significant differences between the two groups in the size of the primary tumor, histologic grading, and size of recurrent tumor. The disease-free interval between primary diagnosis and local recurrence was 8 months shorter in patients after mastectomy than in those after breast-sparing surgery (p = 0.35). Survival after recurrence was shorter in the patients after mastectomy but this difference was not statistically significant (98 vs. 208 months, respectively; p = 0.11). The disease-free interval before local recurrence (but not the type of primary surgery) was the only independent prognostic factor for subsequent survival in both the univariate (p = 0.02) and the multivariate (p = 0.01) analyses. Conclusion: The difference in survival after local recurrence after mastectomy compared with breast-sparing surgery for early breast cancer is small and appears to be associated with different disease-free intervals before local recurrence." @default.
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- W2023209107 date "2001-02-01" @default.
- W2023209107 modified "2023-09-27" @default.
- W2023209107 title "Prognose des Lokalrezidives beim nodalnegativen Mammakarzinom in Abhängigkeit von der Primäroperation - Langzeitergebnisse einer Matched-Pair-Analyse*" @default.
- W2023209107 doi "https://doi.org/10.1055/s-2001-11161" @default.
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