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- W2023211050 abstract "Transplantation has been performed clinically for four decades and has become the standard of care for end-stage organ failure. Understanding of the immunobiology of transplantation has made tremendous advances, but knowledge still lags behind the clinical use. As a result, nonspecific immunosuppression remains the standard therapy. This article presents an overview of current knowledge of the immunobiology of solid organ transplantation, with emphasis on T-cell activation (antigen presentation, CoS) and cellular allograft (transplantation) immunity. The molecular events of T-cell activation, with some emphasis on the sites of action of modern immunosuppression, are reviewed. A simplified approach to understanding the immunobiology and strategy of maintenance immunosuppression is discussed. Key early and late steps in T-cell activation and the sites of action of immunosuppressive agents are reviewed. The required cellular interactions for the alloresponse and the targets of biologic agents used in transplants are reviewed. Special considerations for the immunology in neonates, infants, and children as recipients are provided. Understanding the immunobiology of transplantation is key to making decisions about children with transplants, developing better protocols, and creating tolerance in the future." @default.
- W2023211050 created "2016-06-24" @default.
- W2023211050 creator A5026056715 @default.
- W2023211050 date "2003-12-01" @default.
- W2023211050 modified "2023-10-10" @default.
- W2023211050 title "Transplantation immunology 2003: simplified approach" @default.
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- W2023211050 doi "https://doi.org/10.1016/s0031-3955(03)00119-6" @default.
- W2023211050 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/14710779" @default.
- W2023211050 hasPublicationYear "2003" @default.
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