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• W2023211457 abstract "In Brief Gastrointestinal feeding-related complications (GICs) are common in critically ill patients. Unfortunately, patients at risk for GICs cannot be easily identified. Therefore, we performed a prospective study of 20 critically ill patients to determine the association between a pentagastrin-stimulated gastric acid production test and GICs. Before feeding, the change in the pH of gastric juice was measured in response to a subcutaneous injection of pentagastrin (Gastrotest). We recorded GICs and the feeding volume ratio during each patient’s intensive care unit (ICU) stay. Nineteen patients’ data were analyzed and 9 patients (47%) developed ≥1 GIC, including large gastric residuals, 26%; abdominal distension, 26%; and vomiting, 21%. Patients with GICs had a longer length of ICU stay (mean 21.3, range 5–45 versus 10.1, range 3–32; P < 0.05). The 9 patients (47%) who were Gastrotest responders before starting enteral feeding exhibited a significantly larger volume ratio (P = 0.01) and fewer GICs (1 [11%] versus 8 [80%]; P < 0.05). Abdominal distension was seen in only nonresponders. The positive and negative predictive values for this test’s ability to predict GICs were 80% and 88.9%, respectively. Responding to a pentagastrin-stimulated gastric luminal acid production test is associated with the administration of larger volumes of enteral feed and fewer GICs. IMPLICATIONS: Gastrointestinal feeding-related complications are common in critically ill patients. Unfortunately, patients at risk for these complications cannot be easily identified. In a cohort study of 20 patients, we describe how a functional stress test of the gut using pentagastrin can help identify patients at higher risk for gastrointestinal complications." @default.
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• W2023211457 date "2005-05-01" @default.
• W2023211457 modified "2023-10-16" @default.
• W2023211457 title "The Relationship Between a Pentagastrin-Stimulated Gastric Luminal Acid Production Test (Gastrotest) and Enteral Feeding-Related Gastrointestinal Complications in Critically Ill Patients" @default.
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• W2023211457 doi "https://doi.org/10.1213/01.ane.0000148688.30121.c0" @default.
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