FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2023214282> ?p ?o ?g. }

• W2023214282 endingPage "517" @default.
• W2023214282 startingPage "503" @default.
• W2023214282 abstract "Abstract Ionotropic AMPA receptors (AMPAR) and metabotropic glutamate group I subtype 5 receptors (mGlu5) mediate neuronal and behavioral effects of abused drugs. mG lu5 stimulation increases expression of striatal‐enriched tyrosine phosphatase isoform 61 (STEP 61 ) which internalizes AMPARs. We determined the rat brain profile of these proteins using two different classes of abused drugs, opiates, and stimulants. STEP 61 levels, and cellular distribution/expression of AMPAR subunits (GluA1, GluA2) and mG lu5, were evaluated via a protein cross‐linking assay in medial prefrontal cortex ( mPFC ), nucleus accumbens (NAc), and ventral pallidum (VP) harvested 1 day after acute, or fourteen days after repeated morphine (8 mg/kg) or methamphetamine (1 mg/kg) (treatments producing behavioral sensitization). Acute morphine decreased GluA1 and GluA2 surface expression in mPFC and GluA1 in NAc. Fourteen days after repeated morphine or methamphetamine, mG lu5 surface expression increased in VP. In mPFC , mG lu5 were unaltered; however, after methamphetamine, STEP 61 levels decreased and GluA2 surface expression increased. Pre‐treatment with a mG lu5‐selective negative allosteric modulator, blocked methamphetamine‐induced behavioral sensitization and changes in mPFC GluA2 and STEP 61 . These data reveal (i) region‐specific distinctions in glutamate receptor trafficking between acute and repeated treatments of morphine and methamphetamine, and (ii) that mG lu5 is necessary for methamphetamine‐induced alterations in mPFC GluA2 and STEP 61 ." @default.
• W2023214282 created "2016-06-24" @default.
• W2023214282 creator A5060334059 @default.
• W2023214282 creator A5072500090 @default.
• W2023214282 creator A5074594625 @default.
• W2023214282 date "2013-06-18" @default.
• W2023214282 modified "2023-10-03" @default.
• W2023214282 title "Cellular distribution of AMPA receptor subunits and mGlu5 following acute and repeated administration of morphine or methamphetamine" @default.
• W2023214282 cites W1536279986 @default.
• W2023214282 cites W1573292604 @default.
• W2023214282 cites W1599247107 @default.
• W2023214282 cites W1603471307 @default.
• W2023214282 cites W1606996334 @default.
• W2023214282 cites W1836828237 @default.
• W2023214282 cites W1897360186 @default.
• W2023214282 cites W1902584234 @default.
• W2023214282 cites W1959084093 @default.
• W2023214282 cites W1969124347 @default.
• W2023214282 cites W1976097422 @default.
• W2023214282 cites W1976815849 @default.
• W2023214282 cites W1977929159 @default.
• W2023214282 cites W1979566078 @default.
• W2023214282 cites W1983252720 @default.
• W2023214282 cites W1983762013 @default.
• W2023214282 cites W1983869923 @default.
• W2023214282 cites W1988048218 @default.
• W2023214282 cites W1988279541 @default.
• W2023214282 cites W1988715191 @default.
• W2023214282 cites W1989058665 @default.
• W2023214282 cites W1990286087 @default.
• W2023214282 cites W1991163868 @default.
• W2023214282 cites W1992092449 @default.
• W2023214282 cites W1992351948 @default.
• W2023214282 cites W1992406352 @default.
• W2023214282 cites W1994909073 @default.
• W2023214282 cites W2000255957 @default.
• W2023214282 cites W2000607451 @default.
• W2023214282 cites W2018651989 @default.
• W2023214282 cites W2018843294 @default.
• W2023214282 cites W2022406556 @default.
• W2023214282 cites W2027445806 @default.
• W2023214282 cites W2035524743 @default.
• W2023214282 cites W2037836204 @default.
• W2023214282 cites W2041018266 @default.
• W2023214282 cites W2042511603 @default.
• W2023214282 cites W2045078643 @default.
• W2023214282 cites W2045762415 @default.
• W2023214282 cites W2049683554 @default.
• W2023214282 cites W2050523293 @default.
• W2023214282 cites W2051502943 @default.
• W2023214282 cites W2053929792 @default.
• W2023214282 cites W2064635896 @default.
• W2023214282 cites W2065399310 @default.
• W2023214282 cites W2068352564 @default.
• W2023214282 cites W2070145936 @default.
• W2023214282 cites W2070942862 @default.
• W2023214282 cites W2085210285 @default.
• W2023214282 cites W2087078319 @default.
• W2023214282 cites W2087251224 @default.
• W2023214282 cites W2119588121 @default.
• W2023214282 cites W2123749488 @default.
• W2023214282 cites W2128312680 @default.
• W2023214282 cites W2135307767 @default.
• W2023214282 cites W2137135295 @default.
• W2023214282 cites W2143960888 @default.
• W2023214282 cites W2149875160 @default.
• W2023214282 cites W2165312126 @default.
• W2023214282 cites W4246659915 @default.
• W2023214282 cites W4293247451 @default.
• W2023214282 doi "https://doi.org/10.1111/jnc.12323" @default.
• W2023214282 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/23711322" @default.
• W2023214282 hasPublicationYear "2013" @default.
• W2023214282 type Work @default.
• W2023214282 sameAs 2023214282 @default.
• W2023214282 citedByCount "26" @default.
• W2023214282 countsByYear W20232142822014 @default.
• W2023214282 countsByYear W20232142822015 @default.
• W2023214282 countsByYear W20232142822016 @default.
• W2023214282 countsByYear W20232142822018 @default.
• W2023214282 countsByYear W20232142822019 @default.
• W2023214282 countsByYear W20232142822021 @default.
• W2023214282 countsByYear W20232142822023 @default.
• W2023214282 crossrefType "journal-article" @default.
• W2023214282 hasAuthorship W2023214282A5060334059 @default.
• W2023214282 hasAuthorship W2023214282A5072500090 @default.
• W2023214282 hasAuthorship W2023214282A5074594625 @default.
• W2023214282 hasBestOaLocation W20232142821 @default.
• W2023214282 hasConcept C115955781 @default.
• W2023214282 hasConcept C126322002 @default.
• W2023214282 hasConcept C137183658 @default.
• W2023214282 hasConcept C160268369 @default.
• W2023214282 hasConcept C169760540 @default.
• W2023214282 hasConcept C169900460 @default.
• W2023214282 hasConcept C170493617 @default.
• W2023214282 hasConcept C185592680 @default.
• W2023214282 hasConcept C26702167 @default.
• W2023214282 hasConcept C2776552330 @default.
• W2023214282 hasConcept C2777389121 @default.

• next