FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2023218170> ?p ?o ?g. }

• W2023218170 endingPage "434" @default.
• W2023218170 startingPage "427" @default.
• W2023218170 abstract "The activity of both isozymes of monoamine oxidase (MAO) is reduced by 50% in the brain of human smokers. We hypothesized that this is not an epiphenomenon, but should bring about potentiation of the action of psychostimulant drugs. To test this hypothesis, we carried out serial positron emission tomography (PET) studies in Göttingen miniature pigs to measure the binding of the MAO-A ligand [11C]harmine and to measure the changes in [11C]raclopride binding evoked by a low dose of amphetamine (0.7 mg/kg as free base, i.v.), first in a baseline condition, and, one month later, after acute treatment with pargyline (2 × 3 mg/kg as free base, i.m.). In the baseline, the distribution volume of [11C]harmine relative to the arterial input (Vd, ml g−1) ranged from 74 ml g−1 in cerebellum to 139 ml g−1 in the medial hypothalamus. Pargyline treatment reduced the magnitude of Vd globally to 34–54 ml g−1. Nearly complete displacement of [11C]harmine binding was detected in neocortex and striatum, but there was evidence for pargyline-resistant binding in the pituitary gland and diencephalon. In the baseline condition, the low dose of amphetamine evoked a 14% decline in the binding potential (BP) (pB) of [11C]raclopride in striatum (P = 0.026). After pargyline treatment, the amphetamine effect was of similar magnitude (−11%), although not statistically significant (P = 0.054). However, the second amphetamine challenge evoked a 24% reduction in [11C]raclopride pB relative to the original baseline condition (P = 0.018). Present results do not strongly support our hypothesis that MAO inhibition should potentiate the amphetamine-evoked dopamine release as measured in the [11C]raclopride competition paradigm. Synapse 59:427–434, 2006. © 2006 Wiley-Liss, Inc." @default.
• W2023218170 created "2016-06-24" @default.
• W2023218170 creator A5044995419 @default.
• W2023218170 creator A5066244557 @default.
• W2023218170 creator A5072678278 @default.
• W2023218170 creator A5074389378 @default.
• W2023218170 date "2006-01-01" @default.
• W2023218170 modified "2023-09-23" @default.
• W2023218170 title "Effect of monoamine oxidase inhibition on amphetamine-evoked changes in dopamine receptor availability in the living pig: A dual tracer PET study with [11C]harmine and [11C]raclopride" @default.
• W2023218170 cites W1965999276 @default.
• W2023218170 cites W1970340214 @default.
• W2023218170 cites W1972975822 @default.
• W2023218170 cites W1978013584 @default.
• W2023218170 cites W1982164956 @default.
• W2023218170 cites W1983804154 @default.
• W2023218170 cites W1984327671 @default.
• W2023218170 cites W1985901510 @default.
• W2023218170 cites W1988432402 @default.
• W2023218170 cites W1998269693 @default.
• W2023218170 cites W1998618539 @default.
• W2023218170 cites W2005656534 @default.
• W2023218170 cites W2008440959 @default.
• W2023218170 cites W2009077522 @default.
• W2023218170 cites W2014880675 @default.
• W2023218170 cites W2025782867 @default.
• W2023218170 cites W2025986729 @default.
• W2023218170 cites W2026450745 @default.
• W2023218170 cites W2029397070 @default.
• W2023218170 cites W2030666567 @default.
• W2023218170 cites W2031063806 @default.
• W2023218170 cites W2033802786 @default.
• W2023218170 cites W2035628396 @default.
• W2023218170 cites W2036010949 @default.
• W2023218170 cites W2048024033 @default.
• W2023218170 cites W2048742165 @default.
• W2023218170 cites W2053094857 @default.
• W2023218170 cites W2056628198 @default.
• W2023218170 cites W2056833274 @default.
• W2023218170 cites W2060712684 @default.
• W2023218170 cites W2062446797 @default.
• W2023218170 cites W2068440385 @default.
• W2023218170 cites W2071825212 @default.
• W2023218170 cites W2071962985 @default.
• W2023218170 cites W2076727609 @default.
• W2023218170 cites W2076791599 @default.
• W2023218170 cites W2079092759 @default.
• W2023218170 cites W2080813404 @default.
• W2023218170 cites W2090229163 @default.
• W2023218170 cites W2103818341 @default.
• W2023218170 cites W2109322747 @default.
• W2023218170 cites W2120935254 @default.
• W2023218170 cites W2126683634 @default.
• W2023218170 cites W2137115972 @default.
• W2023218170 cites W2144220495 @default.
• W2023218170 cites W2145587059 @default.
• W2023218170 cites W2150205401 @default.
• W2023218170 cites W2150760506 @default.
• W2023218170 cites W2152545053 @default.
• W2023218170 cites W2153455171 @default.
• W2023218170 cites W2159537672 @default.
• W2023218170 cites W2322700613 @default.
• W2023218170 doi "https://doi.org/10.1002/syn.20258" @default.
• W2023218170 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/16485265" @default.
• W2023218170 hasPublicationYear "2006" @default.
• W2023218170 type Work @default.
• W2023218170 sameAs 2023218170 @default.
• W2023218170 citedByCount "22" @default.
• W2023218170 countsByYear W20232181702012 @default.
• W2023218170 countsByYear W20232181702013 @default.
• W2023218170 countsByYear W20232181702014 @default.
• W2023218170 countsByYear W20232181702015 @default.
• W2023218170 countsByYear W20232181702016 @default.
• W2023218170 countsByYear W20232181702017 @default.
• W2023218170 countsByYear W20232181702021 @default.
• W2023218170 countsByYear W20232181702022 @default.
• W2023218170 crossrefType "journal-article" @default.
• W2023218170 hasAuthorship W2023218170A5044995419 @default.
• W2023218170 hasAuthorship W2023218170A5066244557 @default.
• W2023218170 hasAuthorship W2023218170A5072678278 @default.
• W2023218170 hasAuthorship W2023218170A5074389378 @default.
• W2023218170 hasConcept C126322002 @default.
• W2023218170 hasConcept C134018914 @default.
• W2023218170 hasConcept C181199279 @default.
• W2023218170 hasConcept C185592680 @default.
• W2023218170 hasConcept C2776024655 @default.
• W2023218170 hasConcept C2777067607 @default.
• W2023218170 hasConcept C2777193897 @default.
• W2023218170 hasConcept C2778630814 @default.
• W2023218170 hasConcept C2780062018 @default.
• W2023218170 hasConcept C2781069445 @default.
• W2023218170 hasConcept C2781450507 @default.
• W2023218170 hasConcept C513476851 @default.
• W2023218170 hasConcept C55493867 @default.
• W2023218170 hasConcept C71924100 @default.
• W2023218170 hasConcept C98274493 @default.
• W2023218170 hasConceptScore W2023218170C126322002 @default.
• W2023218170 hasConceptScore W2023218170C134018914 @default.
• W2023218170 hasConceptScore W2023218170C181199279 @default.

• next