Matches in SemOpenAlex for { <https://semopenalex.org/work/W2023218270> ?p ?o ?g. }
- W2023218270 endingPage "642" @default.
- W2023218270 startingPage "633" @default.
- W2023218270 abstract "We propose a tripartite biochemical mechanism for memory. Three physiologic components are involved, namely, the neuron (individual and circuit), the surrounding neural extracellular matrix, and the various trace metals distributed within the matrix. The binding of a metal cation affects a corresponding nanostructure (shrinking, twisting, expansion) and dielectric sensibility of the chelating node (address) within the matrix lattice, sensed by the neuron. The neural extracellular matrix serves as an electro-elastic lattice, wherein neurons manipulate multiple trace metals (n > 10) to encode, store, and decode coginive information. The proposed mechanism explains brains low energy requirements and high rates of storage capacity described in multiples of Avogadro number (NA = 6 × 1023). Supportive evidence correlates memory loss to trace metal toxicity or deficiency, or breakdown in the delivery/transport of metals to the matrix, or its degradation. Inherited diseases revolving around dysfunctional trace metal metabolism and memory dysfunction, include Alzheimer's disease (Al, Zn, Fe), Wilson’s disease (Cu), thalassemia (Fe), and autism (metallothionein). The tripartite mechanism points to the electro-elastic interactions of neurons with trace metals distributed within the neural extracellular matrix, as the molecular underpinning of “synaptic plasticity” affecting short-term memory, long-term memory, and forgetting." @default.
- W2023218270 created "2016-06-24" @default.
- W2023218270 creator A5010924510 @default.
- W2023218270 creator A5019061095 @default.
- W2023218270 date "2012-08-15" @default.
- W2023218270 modified "2023-10-11" @default.
- W2023218270 title "The Molecular Basis of Memory" @default.
- W2023218270 cites W1486617847 @default.
- W2023218270 cites W1500029814 @default.
- W2023218270 cites W1500926156 @default.
- W2023218270 cites W1516104554 @default.
- W2023218270 cites W1542081124 @default.
- W2023218270 cites W1565264541 @default.
- W2023218270 cites W1571281589 @default.
- W2023218270 cites W1581055808 @default.
- W2023218270 cites W1621386939 @default.
- W2023218270 cites W1641143046 @default.
- W2023218270 cites W1690718176 @default.
- W2023218270 cites W1964297303 @default.
- W2023218270 cites W1965838464 @default.
- W2023218270 cites W1966548387 @default.
- W2023218270 cites W1967592491 @default.
- W2023218270 cites W1968128476 @default.
- W2023218270 cites W1969570214 @default.
- W2023218270 cites W1969735301 @default.
- W2023218270 cites W1971353156 @default.
- W2023218270 cites W1971979981 @default.
- W2023218270 cites W1973577845 @default.
- W2023218270 cites W1973669054 @default.
- W2023218270 cites W1974815300 @default.
- W2023218270 cites W1975512627 @default.
- W2023218270 cites W1975791427 @default.
- W2023218270 cites W1975934006 @default.
- W2023218270 cites W1978794431 @default.
- W2023218270 cites W1981479881 @default.
- W2023218270 cites W1982778762 @default.
- W2023218270 cites W1984080147 @default.
- W2023218270 cites W1985582399 @default.
- W2023218270 cites W1988804282 @default.
- W2023218270 cites W1989328178 @default.
- W2023218270 cites W1990297351 @default.
- W2023218270 cites W1992052582 @default.
- W2023218270 cites W1993380666 @default.
- W2023218270 cites W1994681151 @default.
- W2023218270 cites W1995363833 @default.
- W2023218270 cites W1995875735 @default.
- W2023218270 cites W1995890298 @default.
- W2023218270 cites W1997218140 @default.
- W2023218270 cites W1997315349 @default.
- W2023218270 cites W1997397901 @default.
- W2023218270 cites W1999643558 @default.
- W2023218270 cites W2001771035 @default.
- W2023218270 cites W2003538833 @default.
- W2023218270 cites W2003554016 @default.
- W2023218270 cites W2004625314 @default.
- W2023218270 cites W2005013263 @default.
- W2023218270 cites W2006186427 @default.
- W2023218270 cites W2006962813 @default.
- W2023218270 cites W2007001870 @default.
- W2023218270 cites W2007114154 @default.
- W2023218270 cites W2011466907 @default.
- W2023218270 cites W2011868036 @default.
- W2023218270 cites W2013271982 @default.
- W2023218270 cites W2015530052 @default.
- W2023218270 cites W2015852021 @default.
- W2023218270 cites W2016450823 @default.
- W2023218270 cites W2016466873 @default.
- W2023218270 cites W2020714294 @default.
- W2023218270 cites W2023815401 @default.
- W2023218270 cites W2024019011 @default.
- W2023218270 cites W2024186415 @default.
- W2023218270 cites W2026215409 @default.
- W2023218270 cites W2026734386 @default.
- W2023218270 cites W2026895696 @default.
- W2023218270 cites W2027752798 @default.
- W2023218270 cites W2031264132 @default.
- W2023218270 cites W2032458072 @default.
- W2023218270 cites W2033060818 @default.
- W2023218270 cites W2033712541 @default.
- W2023218270 cites W2033764479 @default.
- W2023218270 cites W2034900642 @default.
- W2023218270 cites W2035089473 @default.
- W2023218270 cites W2036893020 @default.
- W2023218270 cites W2036899386 @default.
- W2023218270 cites W2038930547 @default.
- W2023218270 cites W2039285932 @default.
- W2023218270 cites W2039539900 @default.
- W2023218270 cites W2040066177 @default.
- W2023218270 cites W2040555595 @default.
- W2023218270 cites W2041216210 @default.
- W2023218270 cites W2042140776 @default.
- W2023218270 cites W2043537775 @default.
- W2023218270 cites W2043692902 @default.
- W2023218270 cites W2044196510 @default.
- W2023218270 cites W2044233502 @default.
- W2023218270 cites W2045197688 @default.
- W2023218270 cites W2046134741 @default.
- W2023218270 cites W2046463499 @default.