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• W2023220038 abstract "The long QT syndrome (LQTS) is a rare disorder that can cause sudden death in any age group. This syndrome is hereditary in most patients. 1 Moss A.J Schwartz P.J Crampton R.S Locati E.L Carleen E The long QT syndrome a prospective international study. Circulation. 1985; 71: 17-21 Crossref PubMed Scopus (393) Google Scholar Abnormalities in channel cDNA have been detected in some families with the LQTS. 2 Wang Q Shen J Splawski I Atkinson D Li Z Robinson J.L Moss A.J Towbin J.A Keating M.T SCN5A mutations associated with an inherited cardiac arrhythmia, long QT syndrome. Cell. 1995; 80: 805-811 Abstract Full Text PDF PubMed Scopus (1417) Google Scholar , 3 Wang Q Curran M.E Splawski I Burn T.C Millholland J.M VanRaay T.J Shen J Timothy K.W Vincent G.M de Jager T Schwartz P.J Towbin J.A Moss A.J Atkinson D.L Landes G.M Connors T.D Keating M.T Positional cloning of a nobel potassium channel gene KVLQT1 mutations cause cardiac arrhythmias. Nat Genet. 1996; 12: 17-23 Crossref PubMed Scopus (1472) Google Scholar , 4 Benson D.W MacRae C.A Vesely M.R Walsh E.P Seidman J.G Seidman C.E Satler C.A Missense mutation in the pore region of HERG causes familial long QT syndrome. Circulation. 1996; 93: 1791-1795 Crossref PubMed Scopus (76) Google Scholar In patients with LQTS, particularly in children, swimming has been observed to be a specific physical activity that is frequently linked to syncope. 5 Fagius J Sundlof G The diving response in man effect on sympathetic activity in muscle and skin nerve fascicles. J Physiol. 1986; 377: 429-433 Crossref PubMed Scopus (104) Google Scholar , 6 Niimura I Maki T Sudden cardiac death in childhood. Jpn Circ J. 1989; 53: 1571-1580 Crossref PubMed Scopus (30) Google Scholar , 7 Schwartz PJ, Zaza A, Locati E, Moss AJ. Stress and sudden death. The cause of the long QT syndrome. Circulation 1991;83(suppl): II-71–II-80. Google Scholar Many cases of near-drowning during swimming as the first manifestation of the LQTS have been reported, 8 Weintraub R.G Gow R.M Wilkinson J.L The congenital long QT syndrome in childhood. J Am Coll Cardiol. 1990; 16: 674-680 Abstract Full Text PDF PubMed Scopus (96) Google Scholar , 9 Harris E.M Knapp J.F Sharma V The Romano-Ward syndrome a case presenting as near drowning with a clinical review. Pediatr Emerg Care. 1992; 8: 272-275 Crossref PubMed Scopus (12) Google Scholar , 10 Aihoshi S Yoshinaga M Nakamura M Oku S Haraguchi T Nishibatake M Screening for QT prolongation using a new exponential formula. Jpn Circ J. 1995; 59: 185-189 Crossref PubMed Scopus (9) Google Scholar , 11 Ackeman M.J Porter C.J Identification of a family with inherited long QT syndrome after a pediatric near-drowning. Pediatrics. 1998; 101: 306-308 Crossref PubMed Scopus (27) Google Scholar suggesting that the incidence of drowning in patients with LQTS who have not been diagnosed before drowning would be greater than that we suspect, because it is difficult to clarify the cause of sudden death by autopsy alone. 12 Kitada M Nakagawa T Yamaguchi Y A survey of sudden death among school children in Osaka prefecture. Jpn Circ J. 1990; 54: 401-411 Crossref PubMed Scopus (6) Google Scholar All first, seventh, and tenth graders in Japan undergo annual electrocardiography to screen for heart disease. In Kagoshima City, children with prolonged QT intervals without a family history of long QT syndrome or any episode of syncope were identified during these screenings. 10 Aihoshi S Yoshinaga M Nakamura M Oku S Haraguchi T Nishibatake M Screening for QT prolongation using a new exponential formula. Jpn Circ J. 1995; 59: 185-189 Crossref PubMed Scopus (9) Google Scholar Some of these children fulfilled the criteria for definite long QT syndrome established by Schwartz et al. 13 Schwartz P.J Moss A.J Vincent G.M Crampton R.S Diagnostic criteria for the long QT syndrome. An update. Circulation. 1993; 88: 782-784 Crossref PubMed Scopus (968) Google Scholar We investigated the relation between heart rate (HR) and the QT interval using face immersion in cold water in these children and control children." @default.
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• W2023220038 title "Face Immersion in Cold Water Induces Prolongation of the QT Interval and T-Wave Changes in Children With Nonfamilial Long QT Syndrome" @default.
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