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• W2023220359 abstract "Background —The mechanisms through which NOS2-mediated pathways regulate graft failure in acute cardiac rejection are ill defined. To determine whether apoptosis promoted by NOS2 may contribute, we used a heterotopic transplant model to study mouse cardiac allografts placed in recipients with targeted gene deletion of NOS2. Methods and Results —Using 5 different indexes of apoptosis, we showed that mouse cardiac allografts placed in NOS2 −/− recipients (n=7) had reduced apoptotic activity compared with those in NOS2 +/+ controls (n=8). There were significantly fewer TUNEL-positive nuclei per high-powered field ( P <0.01), less DNA fragmentation (antinucleosome ELISA; P <0.05), lower corrected transcript levels for caspase-1 and -3 ( 32 P reverse transcriptase–polymerase chain reaction; P <0.01), and reduced caspase-3 activity (cleavage of DEVD-pNA [ P <0.001] and poly [ADP-ribose] polymerase) in grafts from NOS2 −/− recipients. This concordant reduction in apoptotic indexes paralleled the improved histological outcome of grafts transplanted into NOS2 −/− recipients (assessed as rejection scores; P =0.012). To identify pathways controlled by NOS2, we compared intragraft transcript levels of potential triggers and regulators. Whereas Fas ligand/Fas and tumor necrosis factor (TNF)-α/TNF receptor-1 levels were not altered by NOS2 deficiency, transcript levels for p53 were significantly lower in grafts from NOS2 −/− recipients, coinciding with a significant increase in the antiapoptotic Bcl-2/Bax balance and decrease in Bcl-X l levels. Conclusions —Using NOS2 knockout mice, we demonstrated that NOS2-mediated pathways can promote acute rejection, at least in part, by inducing apoptotic cell death. When NOS2 is present, p53 might control NOS2-mediated apoptosis by stimulating Bax and repressing Bcl-2 and Bcl-X l expression, which may activate the cell death program in the rejecting heart." @default.
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• W2023220359 date "1999-02-16" @default.
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• W2023220359 title "Attenuated Acute Cardiac Rejection in NOS2 −/− Recipients Correlates With Reduced Apoptosis" @default.
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• W2023220359 doi "https://doi.org/10.1161/01.cir.99.6.836" @default.
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