FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2023221086> ?p ?o ?g. }

• W2023221086 endingPage "356" @default.
• W2023221086 startingPage "348" @default.
• W2023221086 abstract "In eukaryotic cells, covalent modifications to core histones contribute to the establishment and maintenance of cellular phenotype via regulation of gene expression. Histone acetyltransferases (HATs) cooperate with histone deacetylases (HDACs) to establish and maintain specific patterns of histone acetylation. HDAC inhibitors can cause pluripotent stem cells to cease proliferating and enter terminal differentiation pathways in culture. To better define the roles of individual HDACs in stem cell differentiation, we have constructed “dominant-negative” stem cell lines expressing mutant, Flag-tagged HDACs with reduced enzymatic activity. Replacement of a single residue (His→Ala) in the catalytic center reduced the activity of HDACs 1 and 2 by 80%, and abolished HDAC3 activity; the mutant HDACs were expressed at similar levels and in the same multiprotein complexes as wild-type HDACs. Hexamethylene bisacetamide-induced MEL cell differentiation was potentiated by the individual mutant HDACs, but only to 2%, versus 60% for an HDAC inhibitor, sodium butyrate, suggesting that inhibition of multiple HDACs is required for full potentiation. Cultured E14.5 cortical stem cells differentiate to neurons, astrocytes, and oligodendrocytes upon withdrawal of basic fibroblast growth factor. Transduction of stem cells with mutant HDACs 1, 2, or 3 shifted cell fate choice toward oligodendrocytes. Mutant HDAC2 also increased differentiation to astrocytes, while mutant HDAC1 reduced differentiation to neurons by 50%. These results indicate that HDAC activity inhibits differentiation to oligodendrocytes, and that HDAC2 activity specifically inhibits differentiation to astrocytes, while HDAC1 activity is required for differentiation to neurons." @default.
• W2023221086 created "2016-06-24" @default.
• W2023221086 creator A5007166283 @default.
• W2023221086 creator A5021862429 @default.
• W2023221086 creator A5033333954 @default.
• W2023221086 creator A5047591792 @default.
• W2023221086 creator A5053438858 @default.
• W2023221086 creator A5055872472 @default.
• W2023221086 creator A5059458188 @default.
• W2023221086 creator A5083412651 @default.
• W2023221086 date "2008-04-01" @default.
• W2023221086 modified "2023-09-23" @default.
• W2023221086 title "Complementary roles for histone deacetylases 1, 2, and 3 in differentiation of pluripotent stem cells" @default.
• W2023221086 cites W1521333964 @default.
• W2023221086 cites W1533942477 @default.
• W2023221086 cites W1567517848 @default.
• W2023221086 cites W1597656413 @default.
• W2023221086 cites W1635667563 @default.
• W2023221086 cites W1637312052 @default.
• W2023221086 cites W1665024321 @default.
• W2023221086 cites W1910848366 @default.
• W2023221086 cites W1964136810 @default.
• W2023221086 cites W1969021739 @default.
• W2023221086 cites W1973759523 @default.
• W2023221086 cites W1976967609 @default.
• W2023221086 cites W1977094101 @default.
• W2023221086 cites W1982619775 @default.
• W2023221086 cites W1985063313 @default.
• W2023221086 cites W1990761249 @default.
• W2023221086 cites W1995902306 @default.
• W2023221086 cites W2002698073 @default.
• W2023221086 cites W2008783666 @default.
• W2023221086 cites W2014817033 @default.
• W2023221086 cites W2020539766 @default.
• W2023221086 cites W2035915355 @default.
• W2023221086 cites W2038439057 @default.
• W2023221086 cites W2038536598 @default.
• W2023221086 cites W2045580211 @default.
• W2023221086 cites W2060913542 @default.
• W2023221086 cites W2071715575 @default.
• W2023221086 cites W2071981322 @default.
• W2023221086 cites W2072793384 @default.
• W2023221086 cites W2073449129 @default.
• W2023221086 cites W2075405431 @default.
• W2023221086 cites W2081973434 @default.
• W2023221086 cites W2092349389 @default.
• W2023221086 cites W2107627035 @default.
• W2023221086 cites W2110938577 @default.
• W2023221086 cites W2111067040 @default.
• W2023221086 cites W2118650392 @default.
• W2023221086 cites W2122828787 @default.
• W2023221086 cites W2125281677 @default.
• W2023221086 cites W2135085078 @default.
• W2023221086 cites W2135830745 @default.
• W2023221086 cites W2143658931 @default.
• W2023221086 cites W2149485430 @default.
• W2023221086 cites W2166984732 @default.
• W2023221086 cites W2169687662 @default.
• W2023221086 cites W2327776901 @default.
• W2023221086 doi "https://doi.org/10.1111/j.1432-0436.2007.00232.x" @default.
• W2023221086 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/4428170" @default.
• W2023221086 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/18021260" @default.
• W2023221086 hasPublicationYear "2008" @default.
• W2023221086 type Work @default.
• W2023221086 sameAs 2023221086 @default.
• W2023221086 citedByCount "48" @default.
• W2023221086 countsByYear W20232210862012 @default.
• W2023221086 countsByYear W20232210862013 @default.
• W2023221086 countsByYear W20232210862014 @default.
• W2023221086 countsByYear W20232210862015 @default.
• W2023221086 countsByYear W20232210862016 @default.
• W2023221086 countsByYear W20232210862018 @default.
• W2023221086 countsByYear W20232210862019 @default.
• W2023221086 countsByYear W20232210862020 @default.
• W2023221086 countsByYear W20232210862022 @default.
• W2023221086 crossrefType "journal-article" @default.
• W2023221086 hasAuthorship W2023221086A5007166283 @default.
• W2023221086 hasAuthorship W2023221086A5021862429 @default.
• W2023221086 hasAuthorship W2023221086A5033333954 @default.
• W2023221086 hasAuthorship W2023221086A5047591792 @default.
• W2023221086 hasAuthorship W2023221086A5053438858 @default.
• W2023221086 hasAuthorship W2023221086A5055872472 @default.
• W2023221086 hasAuthorship W2023221086A5059458188 @default.
• W2023221086 hasAuthorship W2023221086A5083412651 @default.
• W2023221086 hasBestOaLocation W20232210862 @default.
• W2023221086 hasConcept C104317684 @default.
• W2023221086 hasConcept C107459253 @default.
• W2023221086 hasConcept C119157956 @default.
• W2023221086 hasConcept C13721689 @default.
• W2023221086 hasConcept C145103041 @default.
• W2023221086 hasConcept C148738053 @default.
• W2023221086 hasConcept C2778305200 @default.
• W2023221086 hasConcept C2778942008 @default.
• W2023221086 hasConcept C2779085176 @default.
• W2023221086 hasConcept C28328180 @default.
• W2023221086 hasConcept C4951695 @default.
• W2023221086 hasConcept C54355233 @default.
• W2023221086 hasConcept C55493867 @default.

• next