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- W2023221517 abstract "The distribution, morphology, synaptic coverage and postsynaptic targets of calbindin-containing interneurons and afferent pathways have been analyzed in the control and epileptic CA1 region of the human hippocampus. Numerous calbindin-positive interneurons are preserved even in the strongly sclerotic CA1 region. The morphology of individual cells is altered: the cell body and dendrites become spiny, the radially oriented dendrites disappear, and are replaced by a large number of curved, distorted dendrites. Even in the non-sclerotic epileptic samples, where pyramidal cells are present and calbindin-immunoreactive interneurons seem to be unchanged, some modifications could be observed at the electron microscopic level: they received more inhibitory synaptic input, and the calbindin-positive excitatory afferents - presumably derived from the CA1, the CA2 and/or the dentate gyrus - are sprouted. In the strongly sclerotic tissue, with the death of pyramidal cells, calbindin-positive terminals (belonging to interneurons and the remaining excitatory afferents) change their targets. Our data suggest that an intense synaptic reorganization takes place in the epileptic CA1 region, even in the non-sclerotic tissue, before the death of considerable numbers of pyramidal cells. Calbindin-positive interneurons participate in this reorganization: they show plastic changes in response to epilepsy. The enhanced inhibition of inhibitory interneurons may result in the disinhibition of pyramidal cells or in an abnormal synchrony in the output region of the hippocampus." @default.
- W2023221517 created "2016-06-24" @default.
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- W2023221517 date "2002-12-01" @default.
- W2023221517 modified "2023-10-16" @default.
- W2023221517 title "Synaptic reorganization of calbindin-positive neurons in the human hippocampal CA1 region in temporal lobe epilepsy" @default.
- W2023221517 cites W1480770914 @default.
- W2023221517 cites W1501360999 @default.
- W2023221517 cites W1503335897 @default.
- W2023221517 cites W1558225220 @default.
- W2023221517 cites W1827373965 @default.
- W2023221517 cites W1860455432 @default.
- W2023221517 cites W1965758589 @default.
- W2023221517 cites W1967010346 @default.
- W2023221517 cites W1971228531 @default.
- W2023221517 cites W1974570474 @default.
- W2023221517 cites W1975091366 @default.
- W2023221517 cites W1979198709 @default.
- W2023221517 cites W1983572597 @default.
- W2023221517 cites W1984853167 @default.
- W2023221517 cites W1992022377 @default.
- W2023221517 cites W1994597727 @default.
- W2023221517 cites W1997765501 @default.
- W2023221517 cites W1997821918 @default.
- W2023221517 cites W2000354287 @default.
- W2023221517 cites W2004115145 @default.
- W2023221517 cites W2006357342 @default.
- W2023221517 cites W2015575130 @default.
- W2023221517 cites W2016443275 @default.
- W2023221517 cites W2023600327 @default.
- W2023221517 cites W2023697740 @default.
- W2023221517 cites W2031661024 @default.
- W2023221517 cites W2032733489 @default.
- W2023221517 cites W2034474299 @default.
- W2023221517 cites W2035826455 @default.
- W2023221517 cites W2038050402 @default.
- W2023221517 cites W2041579561 @default.
- W2023221517 cites W2042962532 @default.
- W2023221517 cites W2052191318 @default.
- W2023221517 cites W2052923695 @default.
- W2023221517 cites W2053970033 @default.
- W2023221517 cites W2057856146 @default.
- W2023221517 cites W2060589548 @default.
- W2023221517 cites W2063987450 @default.
- W2023221517 cites W2064118583 @default.
- W2023221517 cites W2064767806 @default.
- W2023221517 cites W2066993990 @default.
- W2023221517 cites W2069650489 @default.
- W2023221517 cites W2070864731 @default.
- W2023221517 cites W2072648531 @default.
- W2023221517 cites W2076449006 @default.
- W2023221517 cites W2076664481 @default.
- W2023221517 cites W2077369265 @default.
- W2023221517 cites W2079793054 @default.
- W2023221517 cites W2085193927 @default.
- W2023221517 cites W2085556169 @default.
- W2023221517 cites W2088188719 @default.
- W2023221517 cites W2091441008 @default.
- W2023221517 cites W2095391379 @default.
- W2023221517 cites W2105378686 @default.
- W2023221517 cites W2117130572 @default.
- W2023221517 cites W2120839782 @default.
- W2023221517 cites W2124545724 @default.
- W2023221517 cites W2124793944 @default.
- W2023221517 cites W2125459706 @default.
- W2023221517 cites W2128008306 @default.
- W2023221517 cites W2137545323 @default.
- W2023221517 cites W2142925815 @default.
- W2023221517 cites W2149146804 @default.
- W2023221517 cites W2149618055 @default.
- W2023221517 cites W2151529400 @default.
- W2023221517 cites W2152229069 @default.
- W2023221517 cites W2152357321 @default.
- W2023221517 cites W2153225720 @default.
- W2023221517 cites W2154826398 @default.
- W2023221517 cites W2156625231 @default.
- W2023221517 cites W2159475829 @default.
- W2023221517 cites W2159699960 @default.
- W2023221517 cites W2165340605 @default.
- W2023221517 cites W2166686707 @default.
- W2023221517 cites W2169931873 @default.
- W2023221517 cites W2173317214 @default.
- W2023221517 cites W2318481979 @default.
- W2023221517 cites W2419202108 @default.
- W2023221517 cites W4299835783 @default.
- W2023221517 doi "https://doi.org/10.1016/s0306-4522(02)00264-6" @default.
- W2023221517 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/12435433" @default.
- W2023221517 hasPublicationYear "2002" @default.
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