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- W2023221544 abstract "A micropipette-system was used to investigate intracranial self-injection of morphine in the rat. The system consisted of a glass micropipette (tip dia 5 μm) connected by flexible tubing and a swivel to a pressure source. Using nose-poking through a hole in one wall of the cage as the operant, rats self-injected quantities as small as 50 ng/5 nl of morphine into the ventral tegmental area. In contrast, rats in the saline-treated group and yoked-control group did not increase their rates of nose-poking behaviour above baseline levels. Intermittent reinforcement in the morphine-treated group resulted in a further increase in the rate of nose-poking. Histological inspection of the site of injection revealed minimal damage to brain tissue and likely confinement of the injected solution to the area around the tip of the pipette." @default.
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- W2023221544 date "1989-10-01" @default.
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- W2023221544 title "Self-administration of small amounts of morphine through glass micropipettes into the ventral tegmental area of the rat" @default.
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- W2023221544 doi "https://doi.org/10.1016/0028-3908(89)90112-3" @default.
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