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• W2023222029 abstract "A 4-year-old boy with pure red cell aplasia was investigated. Immunophenotypic analysis of peripheral blood lymphocytes revealed a marked increase of CD20+ cells, which fell from 25.9% in the active stage to 9.7% in remission. The plasma contained a suppressive activity against CFU-e and BFU-e formation by the patient's bone marrow cells, which disappeared when the disease went into remission. Prednisone (2 mg/kg/day) therapy was tried for 5 weeks, but produced no improvement. Subsequently, high-dose gamma-globulin therapy induced complete remission of anemia. A lymphoblastoid B cell line obtained from the patient before therapy produced a factor that suppressed erythropoiesis but not granulopoiesis. The suppressive activity resided in the immunoglobulin fraction and was adsorbed by an anti-immunoglobulin column. These results indicate that expansion of B cells producing an immunoglobulin which suppressed erythropoiesis was involved in the pathogenesis of the disease in this patient." @default.
• W2023222029 created "2016-06-24" @default.
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• W2023222029 date "1991-10-01" @default.
• W2023222029 modified "2023-10-16" @default.
• W2023222029 title "A B Cell line from a patient with pure red cell aplasia produces an immunoglobulin that suppresses erythropoiesis" @default.
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• W2023222029 doi "https://doi.org/10.1016/s0090-1229(06)80004-8" @default.
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