FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2023222694> ?p ?o ?g. }

• W2023222694 endingPage "341" @default.
• W2023222694 startingPage "333" @default.
• W2023222694 abstract "BackgroundUnclassified variant and uninformative BRCA1/2 results are not only relevant for probands to whom results are disclosed but also for untested relatives. Previous studies have seldomly included relatives and have not explained how their lives were influenced by these results. We explored the family communication timeline of genetic counseling: (1) genetic counselors communicate the relatives' cancer risk, (2) probands perceive this risk and (3) communicate this to relatives; (4) relatives perceive this information, and (5) experience an impact on their lives.MethodsWe conducted a retrospective descriptive study in 13 probands with an unclassified variant and 5 with an uninformative result, and in, respectively, 27 and 12 of their untested female relatives from moderate cancer risk families. In questionnaires, probands described their perception of the DNA-test result (i.e., recollections and interpretations of cancer risks and heredity likelihood). Relatives described the communication process, their perception, and impact (i.e., medical decisions, distress, quality of life, and life changes). Bootstrap analysis was used to analyze mediation effects.ResultsThe relatives' own perception strongly predicted breast self-examination, breast/ovarian surveillance or surgery, levels of distress and quality of life, and amount of reported life changes. The extent to which the proband had communicated the DNA-test result in an understandable, direct, reassuring way, predicted the relatives' perception. The actual communicated relatives' cancer risks or the proband's perception did not predict relatives' perception and impact measures. Family characteristics influenced the communication process but not the relatives' perception and outcomes.DiscussionRelatives seem to make poorly informed decisions on the basis of their own perception, which was unrelated to the information that probands had communicated on the basis of the actual communicated result. Therefore, genetic counselors may guide probands in the communication process and may directly inform relatives, if possible. Genet Med 2011:13(4):333–341." @default.
• W2023222694 created "2016-06-24" @default.
• W2023222694 creator A5001391884 @default.
• W2023222694 creator A5035148842 @default.
• W2023222694 creator A5042981384 @default.
• W2023222694 creator A5058359207 @default.
• W2023222694 creator A5060405297 @default.
• W2023222694 creator A5067697862 @default.
• W2023222694 date "2011-04-01" @default.
• W2023222694 modified "2023-09-27" @default.
• W2023222694 title "Family communication matters: The impact of telling relatives about unclassified variants and uninformative DNA-test results" @default.
• W2023222694 cites W1966992237 @default.
• W2023222694 cites W1970325604 @default.
• W2023222694 cites W1975665312 @default.
• W2023222694 cites W1979206718 @default.
• W2023222694 cites W1981691499 @default.
• W2023222694 cites W1983856929 @default.
• W2023222694 cites W2003334151 @default.
• W2023222694 cites W2007941744 @default.
• W2023222694 cites W2009783224 @default.
• W2023222694 cites W2021052761 @default.
• W2023222694 cites W2022728454 @default.
• W2023222694 cites W2026104297 @default.
• W2023222694 cites W2038654351 @default.
• W2023222694 cites W2038702827 @default.
• W2023222694 cites W2039540031 @default.
• W2023222694 cites W2041787437 @default.
• W2023222694 cites W2043162151 @default.
• W2023222694 cites W2059286462 @default.
• W2023222694 cites W2088208067 @default.
• W2023222694 cites W2097012364 @default.
• W2023222694 cites W2102483285 @default.
• W2023222694 cites W2102740368 @default.
• W2023222694 cites W2112228221 @default.
• W2023222694 cites W2118308076 @default.
• W2023222694 cites W2126477565 @default.
• W2023222694 cites W2128315965 @default.
• W2023222694 cites W2142629207 @default.
• W2023222694 cites W2154313945 @default.
• W2023222694 cites W2155053870 @default.
• W2023222694 cites W2156930286 @default.
• W2023222694 cites W216045668 @default.
• W2023222694 cites W2164933217 @default.
• W2023222694 cites W2171137184 @default.
• W2023222694 cites W2171563929 @default.
• W2023222694 cites W313068385 @default.
• W2023222694 cites W4246153512 @default.
• W2023222694 doi "https://doi.org/10.1097/gim.0b013e318204cfed" @default.
• W2023222694 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/21358410" @default.
• W2023222694 hasPublicationYear "2011" @default.
• W2023222694 type Work @default.
• W2023222694 sameAs 2023222694 @default.
• W2023222694 citedByCount "32" @default.
• W2023222694 countsByYear W20232226942012 @default.
• W2023222694 countsByYear W20232226942013 @default.
• W2023222694 countsByYear W20232226942014 @default.
• W2023222694 countsByYear W20232226942015 @default.
• W2023222694 countsByYear W20232226942016 @default.
• W2023222694 countsByYear W20232226942017 @default.
• W2023222694 countsByYear W20232226942018 @default.
• W2023222694 countsByYear W20232226942019 @default.
• W2023222694 countsByYear W20232226942020 @default.
• W2023222694 countsByYear W20232226942021 @default.
• W2023222694 crossrefType "journal-article" @default.
• W2023222694 hasAuthorship W2023222694A5001391884 @default.
• W2023222694 hasAuthorship W2023222694A5035148842 @default.
• W2023222694 hasAuthorship W2023222694A5042981384 @default.
• W2023222694 hasAuthorship W2023222694A5058359207 @default.
• W2023222694 hasAuthorship W2023222694A5060405297 @default.
• W2023222694 hasAuthorship W2023222694A5067697862 @default.
• W2023222694 hasBestOaLocation W20232226941 @default.
• W2023222694 hasConcept C104317684 @default.
• W2023222694 hasConcept C121608353 @default.
• W2023222694 hasConcept C126322002 @default.
• W2023222694 hasConcept C139265228 @default.
• W2023222694 hasConcept C143098186 @default.
• W2023222694 hasConcept C15744967 @default.
• W2023222694 hasConcept C163355716 @default.
• W2023222694 hasConcept C169760540 @default.
• W2023222694 hasConcept C188997412 @default.
• W2023222694 hasConcept C26760741 @default.
• W2023222694 hasConcept C2780673598 @default.
• W2023222694 hasConcept C501734568 @default.
• W2023222694 hasConcept C530470458 @default.
• W2023222694 hasConcept C54355233 @default.
• W2023222694 hasConcept C70410870 @default.
• W2023222694 hasConcept C71924100 @default.
• W2023222694 hasConcept C80227256 @default.
• W2023222694 hasConcept C86803240 @default.
• W2023222694 hasConceptScore W2023222694C104317684 @default.
• W2023222694 hasConceptScore W2023222694C121608353 @default.
• W2023222694 hasConceptScore W2023222694C126322002 @default.
• W2023222694 hasConceptScore W2023222694C139265228 @default.
• W2023222694 hasConceptScore W2023222694C143098186 @default.
• W2023222694 hasConceptScore W2023222694C15744967 @default.
• W2023222694 hasConceptScore W2023222694C163355716 @default.
• W2023222694 hasConceptScore W2023222694C169760540 @default.
• W2023222694 hasConceptScore W2023222694C188997412 @default.

• next