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- W2023222844 abstract "Human peripheral blood mononuclear cells were depleted of lymphocytes to obtain cell preparations enriched for monocytes; in preparations from seven donors the mean percentage of monocytes was 95%. Based on the observation that the binding of IgM cytophilic anti-sheep erythrocyte (SRBC) antibodies to monocytes is temperature dependent, a plaque forming cell (PFC) assay was developed and compared with a rosette test in delineation of IgM-receptor bearing monocytes. Whereas a mean of 2% of freshly prepared monocytes were IgM-receptor positive by rosettes, a mean of 34% formed direct plaques. If monocytes were VCN-treated then passively sensitized with cytophilic IgM anti-SRBC antibodies, means of 57% and 87% formed rosettes and direct plaques respectively; direct comparisons showed that the PFC assay was significantly more sensitive than the comparable rosette tests on both freshly prepared and VCN-treated monocytes. The specificity of plaque formation by VCN-treated monocytes was established in inhibition experiments in which inclusion of IgM but not IgG molecules in the test medium inhibited plaque formation. These results indicate that not only are IgM receptors present on a significant proportion of freshly prepared peripheral blood monocytes but also that some receptors are hidden in the monocytes membranes and can be revealed by VCN-treatment. The PFC assay was shown to have practical advantages over the comparable rosette test in demonstrating IgM-receptor bearing human peripheral blood monocytes." @default.
- W2023222844 created "2016-06-24" @default.
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- W2023222844 date "1979-07-01" @default.
- W2023222844 modified "2023-09-23" @default.
- W2023222844 title "Demonstration of IgM receptors on human peripheral blood monocytes using a direct plaque forming cell (PFC) assay" @default.
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- W2023222844 doi "https://doi.org/10.1016/0022-1759(79)90331-4" @default.
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