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• W2023225118 abstract "The inhibiting effect of (R,S)-propranolol on peripheral T4/T3 conversion can be related to the (R)-isomer. The intention of this study is to clarify if (R)-4-hydroxypropranolol, a main metabolite of (R)-propranolol, develops the same or even a stronger effect on peripheral thyroxine metabolism as the parent drug. (R)-4-hydroxypropranolol was synthesized via (R)-4-methoxypropranolol and their optical purity was checked chromatographically. Twenty patients suffering from hyperthyroidism were divided into five groups and treated with (R)-4-hydroxypropranolol · HCl in dosages from 12 to 75 mg per day in a placebo controlled study over a period of 5 days. The serum hormone levels and resting pulse rate were measured. No significant changes of thyroid parameter could be observed but a significant decrease of resting pulse rate under treatment with 75 mg (R)-4-hydroxypropranolol occurred. It could be concluded that (R)-4-hydroxypropranolol possesses negative chronotropic effects but develops no changes in thyroid hormone metabolism in hyperthyroid patients." @default.
• W2023225118 created "2016-06-24" @default.
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• W2023225118 date "1991-01-01" @default.
• W2023225118 modified "2023-10-08" @default.
• W2023225118 title "Synthesis and effects on peripheral thyroid hormone conversion of (R)-4-hydroxypropranolol, a main metabolite of (R)-propranolol" @default.
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• W2023225118 doi "https://doi.org/10.1002/chir.530030212" @default.
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