FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2023225473> ?p ?o ?g. }

• W2023225473 endingPage "20120004" @default.
• W2023225473 startingPage "20120004" @default.
• W2023225473 abstract "As a neurotransmitter, serotonin (5-HT) is widely used throughout the brain and known to play a role in many processes including emotion and brain development. Of the 15 subtypes of 5-HT receptors, the 1A receptor (5-HT(1A)) has been implicated in depression and suicide. Using the [carbonyl-(11)C]WAY100635 ([(11)C]WAY) ligand and positron emission tomography, we have studied the 5-HT(1A) receptor, first in a group of healthy controls, then in two separate groups of subjects with major depressive disorder (MDD) (antidepressant exposed and not recently medicated), and, lastly, in a group of subjects remitted from MDD. All MDD subjects were medication-free at the time of scan. We found higher 5-HT(1A) binding potential (BP(F)) in MDD subjects not recently exposed to an antidepressant compared with controls and recently medicated MDD subjects; and higher BP(F) in subjects with the C(-1019)G promoter polymorphism. We replicated these findings in a novel cohort and reconciled our discrepant findings with other groups using alternate quantification techniques. We also reported higher BP(F) in subjects remitted from a major depressive episode than in controls. From this work, we proposed a temporal model in which 5-HT(1A) BP(F) may be a trait abnormality of MDD. To further explore the genetic components of MDD and utility of 5-HT(1A) imaging as a potential tool for biomarker or treatment response prediction, these findings should be replicated in a larger cohort using the [(11)C]CUMI-101 agonist tracer." @default.
• W2023225473 created "2016-06-24" @default.
• W2023225473 creator A5023581810 @default.
• W2023225473 creator A5041352402 @default.
• W2023225473 date "2013-04-05" @default.
• W2023225473 modified "2023-10-08" @default.
• W2023225473 title "Imaging the serotonin 1A receptor using [ ¹¹ C]WAY100635 in healthy controls and major depression" @default.
• W2023225473 cites W1928975456 @default.
• W2023225473 cites W1977465442 @default.
• W2023225473 cites W1979843284 @default.
• W2023225473 cites W1985445017 @default.
• W2023225473 cites W1986511266 @default.
• W2023225473 cites W1991461979 @default.
• W2023225473 cites W2003500723 @default.
• W2023225473 cites W2018453129 @default.
• W2023225473 cites W2020187940 @default.
• W2023225473 cites W2021592118 @default.
• W2023225473 cites W2021813066 @default.
• W2023225473 cites W2028524283 @default.
• W2023225473 cites W2028977103 @default.
• W2023225473 cites W2031955709 @default.
• W2023225473 cites W2032610103 @default.
• W2023225473 cites W2035361052 @default.
• W2023225473 cites W2035975261 @default.
• W2023225473 cites W2037241563 @default.
• W2023225473 cites W2039272568 @default.
• W2023225473 cites W2050087878 @default.
• W2023225473 cites W2050451612 @default.
• W2023225473 cites W2051670734 @default.
• W2023225473 cites W2055087364 @default.
• W2023225473 cites W2057532104 @default.
• W2023225473 cites W2058747520 @default.
• W2023225473 cites W2068697920 @default.
• W2023225473 cites W2075327466 @default.
• W2023225473 cites W2080813404 @default.
• W2023225473 cites W2081038995 @default.
• W2023225473 cites W2081328480 @default.
• W2023225473 cites W2081458788 @default.
• W2023225473 cites W2082076406 @default.
• W2023225473 cites W2105346851 @default.
• W2023225473 cites W2106885532 @default.
• W2023225473 cites W2109991255 @default.
• W2023225473 cites W2112278807 @default.
• W2023225473 cites W2116321820 @default.
• W2023225473 cites W2116517414 @default.
• W2023225473 cites W2117671988 @default.
• W2023225473 cites W2123266065 @default.
• W2023225473 cites W2124216937 @default.
• W2023225473 cites W2135190897 @default.
• W2023225473 cites W2139351430 @default.
• W2023225473 cites W2158271326 @default.
• W2023225473 cites W2158770881 @default.
• W2023225473 cites W2159399023 @default.
• W2023225473 cites W2169374157 @default.
• W2023225473 cites W2169615651 @default.
• W2023225473 cites W2170684975 @default.
• W2023225473 cites W4231169313 @default.
• W2023225473 doi "https://doi.org/10.1098/rstb.2012.0004" @default.
• W2023225473 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/3638381" @default.
• W2023225473 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/23440462" @default.
• W2023225473 hasPublicationYear "2013" @default.
• W2023225473 type Work @default.
• W2023225473 sameAs 2023225473 @default.
• W2023225473 citedByCount "47" @default.
• W2023225473 countsByYear W20232254732013 @default.
• W2023225473 countsByYear W20232254732014 @default.
• W2023225473 countsByYear W20232254732015 @default.
• W2023225473 countsByYear W20232254732016 @default.
• W2023225473 countsByYear W20232254732017 @default.
• W2023225473 countsByYear W20232254732018 @default.
• W2023225473 countsByYear W20232254732019 @default.
• W2023225473 countsByYear W20232254732020 @default.
• W2023225473 countsByYear W20232254732021 @default.
• W2023225473 countsByYear W20232254732023 @default.
• W2023225473 crossrefType "journal-article" @default.
• W2023225473 hasAuthorship W2023225473A5023581810 @default.
• W2023225473 hasAuthorship W2023225473A5041352402 @default.
• W2023225473 hasBestOaLocation W20232254731 @default.
• W2023225473 hasConcept C118552586 @default.
• W2023225473 hasConcept C126322002 @default.
• W2023225473 hasConcept C134018914 @default.
• W2023225473 hasConcept C139719470 @default.
• W2023225473 hasConcept C143998085 @default.
• W2023225473 hasConcept C15744967 @default.
• W2023225473 hasConcept C162324750 @default.
• W2023225473 hasConcept C170493617 @default.
• W2023225473 hasConcept C2775864247 @default.
• W2023225473 hasConcept C2776867660 @default.
• W2023225473 hasConcept C2779144063 @default.
• W2023225473 hasConcept C2779177272 @default.
• W2023225473 hasConcept C2780051608 @default.
• W2023225473 hasConcept C2781161787 @default.
• W2023225473 hasConcept C2781197716 @default.
• W2023225473 hasConcept C54355233 @default.
• W2023225473 hasConcept C60592354 @default.
• W2023225473 hasConcept C71924100 @default.
• W2023225473 hasConcept C72563966 @default.
• W2023225473 hasConcept C86803240 @default.

• next