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• W2023226770 abstract "Since systemic sclerosis (SSc) also involves the heart, the aim of the present study was to evaluate possible differences in right ventricular (RV) pump function between SSc-associated pulmonary arterial hypertension (PAH; SScPAH) and idiopathic PAH (IPAH). In 13 limited cutaneous SScPAH and 17 IPAH patients, RV pump function was described using the pump function graph, which relates mean RV pressure (<i>P̄</i>_RV) and stroke volume index (SVI). Differences in pump function result in shift or rotation of the pump function graph. <i>P̄</i>_RV and SVI were measured using standard catheterisation. The hypothetical isovolumic <i>P̄</i>_RV (<i>P̄</i>_RV,iso) was estimated using a single-beat method. The pump function graph was approximated by a parabola: <i>P̄</i>_RV = <i>P̄</i>_RV,iso[1–(SVI/SVI_max)²], where SVI_maxis the hypothetical maximal SVI at zero <i>P̄</i>_RV, enabling calculation of SVI_max. There were no differences in SVI and SVI_max. Both <i>P̄</i>_RV and <i>P̄</i>_RV,iso were significantly lower in SScPAH than in IPAH (<i>P̄</i>_RV 30.7±8.5 <i>versus</i> 41.2±9.4 mmHg; <i>P̄</i>_RV,iso 43.1±12.4 <i>versus</i> 53.5±10.0 mmHg). Since higher pressures were found at similar SVI, the difference in the pump function graph results from lower contractility in SScPAH than in IPAH. Right ventricular contractility is lower in systemic sclerosis-associated pulmonary arterial hypertension than in idiopathic pulmonary arterial hypertension." @default.
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• W2023226770 date "2008-03-05" @default.
• W2023226770 modified "2023-09-23" @default.
• W2023226770 title "Right ventricular contractility in systemic sclerosis-associated and idiopathic pulmonary arterial hypertension" @default.
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• W2023226770 doi "https://doi.org/10.1183/09031936.00135407" @default.
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