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- W2023227631 abstract "We engineered B7-1 retroviral and adenoviral gene transfer systems and studied them in four immunogenic tumor models. M-MSV tumor cells, but not K-Balb, 38.2 and 205 tumor cells, when expressing B7-1 by retroviral transduction were rejected and conferred protection against a tumor challenge. Transient expression of B7-1 after transduction with adenoviruses was less efficient. We observed enhanced cytotoxic T-lymphocyte activity accompanied by increased secretion of IL-6, IFNγ and GM-CSF. GM-CSF secretion correlated with tumor rejection. Enhanced IFNγ but unchanged IL-4 secretion suggested a T-helper 1-mediated anti-tumor immune response." @default.
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- W2023227631 date "1998-12-11" @default.
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- W2023227631 title "Anti-tumor immunity generated by tumor cells engineered to express B7-1 via retroviral or adenoviral gene transfer" @default.
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- W2023227631 doi "https://doi.org/10.1016/s0304-3835(98)00274-2" @default.
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