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- W2023228488 abstract "By means of push-pull perfusions of localized areas in the caudate nucleus, lateral hypothalamus or midbrain reticular formation, the metabolism in vivo of [14C]-5-hydroxytryptamine ([14C]-5-HT) injected intracranially was examined in rats which drank ethanol chronically, rats given ethanol acutely and in controls. A significantly greater conversion of [14C]-5-HT to [14C]-5-hydroxyindoleacetic acid ([14C]-5-HIAA) was observed in the caudate nucleus of the acute ethanol rats as compared to the controls. In the ethanol drinkers, the mean levels of [14C]-5-HT and [14C]-5-HIAA generally fell between those of the control and acute ethanol rats. No large differences were found between the three groups in the production of [14C]-5-hydroxytryptophol ([14C]-5-HTOL) within the localized areas of perfusion. It appears that in some parts of the central nervous system, the presence of ethanol may result in increased degradation of 5-HT to 5-HIAA, but does not result in a greatly increased production of 5-HTOL, as seen in the periphery. These results obtained with the conscious animal further suggest that an interaction exists between 5-HT metabolism and ethanol consumption and provide support for earlier work indicating that the relationships may be different for peripheral systems and the brain." @default.
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- W2023228488 date "1973-02-01" @default.
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- W2023228488 title "Metabolism of [14C]-serotonin in the caudate nucleus, hypothalamus and reticular formation of the rat after ethanol administration" @default.
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- W2023228488 doi "https://doi.org/10.1016/0006-2952(73)90417-6" @default.
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