FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2023229209> ?p ?o ?g. }

• W2023229209 endingPage "299" @default.
• W2023229209 startingPage "291" @default.
• W2023229209 abstract "Our previous computer models suggested that intraluminal thrombus (ILT) within an abdominal aortic aneurysm (AAA) attenuates oxygen diffusion to the AAA wall, possibly causing localized hypoxia and contributing to wall weakening. The purpose of this work was to investigate this possibility.In one arm of this study, patients with AAA were placed in one of two groups: (1) those with an ILT of 4-mm or greater thickness on the anterior surface or (2) those with little (< 4 mm) or no ILT at this site. During surgical resection but before aortic cross-clamping, a needle-type polarographic partial pressure of oxygen (PO2) electrode was inserted into the wall of the exposed AAA, and the PO2 was measured. The probe was advanced, and measurements were made midway through the thrombus and in the lumen. Mural and mid-ILT PO2 measurements were normalized by the intraluminal PO2 measurement to account for patient variability. In the second arm of this study, two AAA wall specimens were obtained from two different sites of the same aneurysm at the time of surgical resection: group I specimens had thick adherent ILT, and group II specimens had thinner or no adherent ILT. Nonaneurysmal tissue was also obtained from the infrarenal aorta of organ donors. Specimens were subjected to histologic, immunohistochemical, and tensile strength analyses to provide data on degree of inflammation (% area inflammatory cells), neovascularization (number of capillaries per high-power field), and tensile strength (peak attainable load). Additional specimens were subjected to Western blotting and immunohistochemistry for qualitative evaluation of expression of the cellular hypoxia marker oxygen-regulated protein.The PO2 measured within the AAA wall in group I (n = 4) and group II (n = 7) patients was 18% +/- 9% luminal value versus 60% +/- 6% (mean +/- SEM; P <.01). The normalized PO2 within the ILT of group I patients was 39% +/- 10% (P =.08 with respect to the group I wall value). Group I tissue specimens showed greater inflammation (P <.05) compared with both group II specimens and nonaneurysmal tissue: 2.9% +/- 0.6% area (n = 7) versus 1.7% +/- 0.3% area (n = 7) versus 0.2% +/- 0.1% area (n = 3), respectively. We found similar differences for neovascularization (number of vessels/high-power field), but only group I versus control was significantly different (P <.05): 16.9 +/- 1.6 (n = 7) vs 13.0 +/- 2.3 (n = 7) vs 8.7 +/- 2.0 (n = 3), respectively. Both Western blotting and immunohistochemistry results suggest that oxygen-regulated protein is more abundantly expressed in group I versus group II specimens. Tensile strength of group I specimens was significantly less (P <.05) than that for group II specimens: 138 +/- 19 N/cm2 (n = 7) versus 216 +/- 34 N/cm2 (n = 7), respectively.Our results suggest that localized hypoxia occurs in regions of thicker ILT in AAA. This may lead to increased, localized mural neovascularization and inflammation, as well as regional wall weakening. We conclude that ILT may play an important role in the pathology and natural history of AAA." @default.
• W2023229209 created "2016-06-24" @default.
• W2023229209 creator A5006318631 @default.
• W2023229209 creator A5009353556 @default.
• W2023229209 creator A5020014751 @default.
• W2023229209 creator A5021711767 @default.
• W2023229209 creator A5039147795 @default.
• W2023229209 creator A5039348262 @default.
• W2023229209 creator A5047145161 @default.
• W2023229209 date "2001-08-01" @default.
• W2023229209 modified "2023-10-11" @default.
• W2023229209 title "Association of intraluminal thrombus in abdominal aortic aneurysm with local hypoxia and wall weakening" @default.
• W2023229209 cites W153003678 @default.
• W2023229209 cites W1652028084 @default.
• W2023229209 cites W1961909698 @default.
• W2023229209 cites W1965445560 @default.
• W2023229209 cites W1978084841 @default.
• W2023229209 cites W1985712533 @default.
• W2023229209 cites W1987656388 @default.
• W2023229209 cites W1988327870 @default.
• W2023229209 cites W1991901773 @default.
• W2023229209 cites W1992100043 @default.
• W2023229209 cites W1998047564 @default.
• W2023229209 cites W2006665634 @default.
• W2023229209 cites W2006927487 @default.
• W2023229209 cites W2009589488 @default.
• W2023229209 cites W2011145014 @default.
• W2023229209 cites W2016607156 @default.
• W2023229209 cites W2017011847 @default.
• W2023229209 cites W2027072703 @default.
• W2023229209 cites W2030176576 @default.
• W2023229209 cites W2036798935 @default.
• W2023229209 cites W2044192395 @default.
• W2023229209 cites W2048497399 @default.
• W2023229209 cites W2053060309 @default.
• W2023229209 cites W2058298189 @default.
• W2023229209 cites W2071052021 @default.
• W2023229209 cites W2074179446 @default.
• W2023229209 cites W2075234146 @default.
• W2023229209 cites W2081918059 @default.
• W2023229209 cites W2086321931 @default.
• W2023229209 cites W2092116904 @default.
• W2023229209 cites W2094743529 @default.
• W2023229209 cites W2096692775 @default.
• W2023229209 cites W2107676587 @default.
• W2023229209 cites W2111204906 @default.
• W2023229209 cites W2111228702 @default.
• W2023229209 cites W2113203220 @default.
• W2023229209 cites W2120639656 @default.
• W2023229209 cites W2123339245 @default.
• W2023229209 cites W2142297495 @default.
• W2023229209 cites W2152938302 @default.
• W2023229209 cites W2154559263 @default.
• W2023229209 cites W2410606948 @default.
• W2023229209 doi "https://doi.org/10.1067/mva.2001.114813" @default.
• W2023229209 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/11496282" @default.
• W2023229209 hasPublicationYear "2001" @default.
• W2023229209 type Work @default.
• W2023229209 sameAs 2023229209 @default.
• W2023229209 citedByCount "428" @default.
• W2023229209 countsByYear W20232292092012 @default.
• W2023229209 countsByYear W20232292092013 @default.
• W2023229209 countsByYear W20232292092014 @default.
• W2023229209 countsByYear W20232292092015 @default.
• W2023229209 countsByYear W20232292092016 @default.
• W2023229209 countsByYear W20232292092017 @default.
• W2023229209 countsByYear W20232292092018 @default.
• W2023229209 countsByYear W20232292092019 @default.
• W2023229209 countsByYear W20232292092020 @default.
• W2023229209 countsByYear W20232292092021 @default.
• W2023229209 countsByYear W20232292092022 @default.
• W2023229209 countsByYear W20232292092023 @default.
• W2023229209 crossrefType "journal-article" @default.
• W2023229209 hasAuthorship W2023229209A5006318631 @default.
• W2023229209 hasAuthorship W2023229209A5009353556 @default.
• W2023229209 hasAuthorship W2023229209A5020014751 @default.
• W2023229209 hasAuthorship W2023229209A5021711767 @default.
• W2023229209 hasAuthorship W2023229209A5039147795 @default.
• W2023229209 hasAuthorship W2023229209A5039348262 @default.
• W2023229209 hasAuthorship W2023229209A5047145161 @default.
• W2023229209 hasBestOaLocation W20232292091 @default.
• W2023229209 hasConcept C105702510 @default.
• W2023229209 hasConcept C126838900 @default.
• W2023229209 hasConcept C131631996 @default.
• W2023229209 hasConcept C141071460 @default.
• W2023229209 hasConcept C142724271 @default.
• W2023229209 hasConcept C2776098176 @default.
• W2023229209 hasConcept C2777323849 @default.
• W2023229209 hasConcept C2779980429 @default.
• W2023229209 hasConcept C2779993416 @default.
• W2023229209 hasConcept C2780520971 @default.
• W2023229209 hasConcept C2781362458 @default.
• W2023229209 hasConcept C71924100 @default.
• W2023229209 hasConceptScore W2023229209C105702510 @default.
• W2023229209 hasConceptScore W2023229209C126838900 @default.
• W2023229209 hasConceptScore W2023229209C131631996 @default.
• W2023229209 hasConceptScore W2023229209C141071460 @default.
• W2023229209 hasConceptScore W2023229209C142724271 @default.

• next