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- W2023229364 abstract "Elevations in β-amyloid peptide (Aβ) levels after traumatic brain injury (TBI) may confer risk for developing Alzheimer's disease in head trauma patients. We investigated the effects of simvastatin, a 3-hydroxy-3-methylglutaryl-CoA reductase inhibitor, on hippocampal Aβ burden in a clinically relevant head injury/intervention model using mice expressing human Aβ. Simvastatin therapy blunted TBI-induced increases in Aβ, reduced hippocampal tissue damage and microglial activation, and improved behavioral outcome. The ability of statins to reduce post-injury Aβ load and ameliorate pathological sequelae of brain injury makes them potentially effective in reducing the risk of developing Alzheimer's disease in TBI patients. Ann Neurol 2009;66:407–414" @default.
- W2023229364 created "2016-06-24" @default.
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- W2023229364 date "2009-09-01" @default.
- W2023229364 modified "2023-09-23" @default.
- W2023229364 title "Simvastatin therapy prevents brain trauma-induced increases in β-amyloid peptide levels" @default.
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- W2023229364 doi "https://doi.org/10.1002/ana.21731" @default.
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