Matches in SemOpenAlex for { <https://semopenalex.org/work/W2023229685> ?p ?o ?g. }
Showing items 1 to 92 of
92
with 100 items per page.
- W2023229685 abstract "Introduction Abnormalities of the colonic mucosa have been implicated in the pathogenesis of ulcerative colitis (UC). We investigated mRNA profiles of macroscopically non-inflamed mucosal biopsies from the colon in patients with UC, Crohn’s disease (CD) and control subjects without gastrointestinal disease (HC), to identify genes that might be involved in the aetiology of the disease. Methods Paired biopsies were taken for histology and mRNA extraction from macroscopically non-inflamed mucosa in the ascending and descending colon, and the rectum, from 24 patients with UC, 14 with CD and 27 HCs undergoing routine colonoscopy. Patients were in complete clinical remission and were either on no treatment or on 5-aminosalicylates ± azathioprine. cRNA was hybridised to Illumina HumanHT-12 v4 Expression Beadchips. Array expression data were log transformed and normalised. Only probes with a detection p-value Results In group comparisons, of the 26,261 expressed probes, Family with Sequence Similarity 5, member C ( FAM5C ) was the only gene to be significantly under-expressed in UC, both in the rectum (FC = –1.58, p = 0.0008) and the descending colon (FC = –1.64, p = 0.0011). Outlier analysis showed that FAM5C was also grossly under-expressed in the ascending colon in 37.5% of UC patients, demonstrating that its expression is abnormal throughout the colon in a significant proportion of individuals. Expression levels were not abnormal in CD. Expression of FAM5C in UC did not correlate with the known markers of inflammation, IL-8 , S100A8 , DEFA5 and DEFA6 , or with treatment. The under-expression of FAM5C in UC was confirmed in biopsies of non-inflamed rectal mucosa from an independent cohort of patients (FC = –1.68, p = 0.0073) and by qPCR (p Conclusion This is the first description of the under-expression of FAM5C in UC. As these observations were made in non-inflamed mucosa, low levels of this protein might be involved in the pathogenesis of the disease. Indications that FAM5C may function as tumour suppressor [1], could link to the observed predisposition to colonic malignancy in UC. Disclosure of Interest None Declared. Reference Kuriowa T et al. (2009) Oncol Rep, 1005–11." @default.
- W2023229685 created "2016-06-24" @default.
- W2023229685 creator A5011340913 @default.
- W2023229685 creator A5032730075 @default.
- W2023229685 creator A5049892030 @default.
- W2023229685 creator A5067123744 @default.
- W2023229685 creator A5071167767 @default.
- W2023229685 creator A5072012157 @default.
- W2023229685 creator A5082895750 @default.
- W2023229685 creator A5084284002 @default.
- W2023229685 creator A5087491333 @default.
- W2023229685 creator A5089342651 @default.
- W2023229685 date "2013-05-01" @default.
- W2023229685 modified "2023-10-18" @default.
- W2023229685 title "Su1770 Fam5c, a Possible Causal Molecule in Ulcerative Colitis Revealed Through a Transcriptomic Analysis of the Bowel Mucosa" @default.
- W2023229685 doi "https://doi.org/10.1016/s0016-5085(13)61747-3" @default.
- W2023229685 hasPublicationYear "2013" @default.
- W2023229685 type Work @default.
- W2023229685 sameAs 2023229685 @default.
- W2023229685 citedByCount "0" @default.
- W2023229685 crossrefType "journal-article" @default.
- W2023229685 hasAuthorship W2023229685A5011340913 @default.
- W2023229685 hasAuthorship W2023229685A5032730075 @default.
- W2023229685 hasAuthorship W2023229685A5049892030 @default.
- W2023229685 hasAuthorship W2023229685A5067123744 @default.
- W2023229685 hasAuthorship W2023229685A5071167767 @default.
- W2023229685 hasAuthorship W2023229685A5072012157 @default.
- W2023229685 hasAuthorship W2023229685A5082895750 @default.
- W2023229685 hasAuthorship W2023229685A5084284002 @default.
- W2023229685 hasAuthorship W2023229685A5087491333 @default.
- W2023229685 hasAuthorship W2023229685A5089342651 @default.
- W2023229685 hasConcept C121608353 @default.
- W2023229685 hasConcept C126322002 @default.
- W2023229685 hasConcept C142724271 @default.
- W2023229685 hasConcept C2775862500 @default.
- W2023229685 hasConcept C2775934546 @default.
- W2023229685 hasConcept C2778260677 @default.
- W2023229685 hasConcept C2778292851 @default.
- W2023229685 hasConcept C2778435480 @default.
- W2023229685 hasConcept C2779134260 @default.
- W2023229685 hasConcept C2780479503 @default.
- W2023229685 hasConcept C2780833581 @default.
- W2023229685 hasConcept C2780942790 @default.
- W2023229685 hasConcept C2781074409 @default.
- W2023229685 hasConcept C3019368612 @default.
- W2023229685 hasConcept C526805850 @default.
- W2023229685 hasConcept C71924100 @default.
- W2023229685 hasConcept C90924648 @default.
- W2023229685 hasConceptScore W2023229685C121608353 @default.
- W2023229685 hasConceptScore W2023229685C126322002 @default.
- W2023229685 hasConceptScore W2023229685C142724271 @default.
- W2023229685 hasConceptScore W2023229685C2775862500 @default.
- W2023229685 hasConceptScore W2023229685C2775934546 @default.
- W2023229685 hasConceptScore W2023229685C2778260677 @default.
- W2023229685 hasConceptScore W2023229685C2778292851 @default.
- W2023229685 hasConceptScore W2023229685C2778435480 @default.
- W2023229685 hasConceptScore W2023229685C2779134260 @default.
- W2023229685 hasConceptScore W2023229685C2780479503 @default.
- W2023229685 hasConceptScore W2023229685C2780833581 @default.
- W2023229685 hasConceptScore W2023229685C2780942790 @default.
- W2023229685 hasConceptScore W2023229685C2781074409 @default.
- W2023229685 hasConceptScore W2023229685C3019368612 @default.
- W2023229685 hasConceptScore W2023229685C526805850 @default.
- W2023229685 hasConceptScore W2023229685C71924100 @default.
- W2023229685 hasConceptScore W2023229685C90924648 @default.
- W2023229685 hasLocation W20232296851 @default.
- W2023229685 hasOpenAccess W2023229685 @default.
- W2023229685 hasPrimaryLocation W20232296851 @default.
- W2023229685 hasRelatedWork W17471283 @default.
- W2023229685 hasRelatedWork W2007466515 @default.
- W2023229685 hasRelatedWork W2010768982 @default.
- W2023229685 hasRelatedWork W2021244329 @default.
- W2023229685 hasRelatedWork W2026747326 @default.
- W2023229685 hasRelatedWork W2039919573 @default.
- W2023229685 hasRelatedWork W2042363953 @default.
- W2023229685 hasRelatedWork W2042948187 @default.
- W2023229685 hasRelatedWork W2046667750 @default.
- W2023229685 hasRelatedWork W2063155653 @default.
- W2023229685 hasRelatedWork W2067813026 @default.
- W2023229685 hasRelatedWork W2075128394 @default.
- W2023229685 hasRelatedWork W2087755497 @default.
- W2023229685 hasRelatedWork W2094301972 @default.
- W2023229685 hasRelatedWork W2166021878 @default.
- W2023229685 hasRelatedWork W2369114647 @default.
- W2023229685 hasRelatedWork W2389114937 @default.
- W2023229685 hasRelatedWork W2396512995 @default.
- W2023229685 hasRelatedWork W2469283303 @default.
- W2023229685 hasRelatedWork W2794298883 @default.
- W2023229685 isParatext "false" @default.
- W2023229685 isRetracted "false" @default.
- W2023229685 magId "2023229685" @default.
- W2023229685 workType "article" @default.