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• W2023230738 abstract "THE GLORIOUS DAYS OF CELLULAR IMMUNOLOGY: NEW YORK UNIVERSITY YEARS AND BEYOND, AN INTERNATIONAL EXPERIENCE BARUJ BENACERRAF* I have derived such benefits, first as a student and later as a scientist, from international cooperation that I contracted a debt that could only be repaid by the contribution I have tried to make to the training of foreign fellows. I was born in Venezuela and educated first in France and later in the United States, where I was trained as a physician and a scientist. I consider , therefore, that I belong to the privileged group that has derived enormous benefits from the willingness of developed countries to train students from foreign lands in the modern disciplines of science. I entered biomedical research, and particularly immunological research, in a golden era, when an enlightened attitude of the U.S. Congress made government funds increasingly available for the support of science, when international communication and cooperation in science flourished as never before, and during which the progress and discoveries in my own field have transformed our discipline from a medically oriented division of microbiology into a major biological science with a modern sophisticated technology applicable to so many biomedical problems. In our lifetime as scientists, the immune system has been successfully analyzed, the structure of immunoglobulins understood [1], the genes coding for their polypeptide chains identified [2, 3], and the mechanisms for the generation of diversity documented [4]. Moreover, the cells responsible for the various functions of the immune system have been identified [5, 6]. The intricate regulatory mechanisms responsible for homeostasis in this complex system, involving interactions between lymphocytes of all classes and controlled by gene products of the major histocompatibility complex, have been brought to light [I]. This im- *Chairman, Department of Pathology, Harvard Medical School, 25 Shattuck Street, Boston, Massachusetts 02115.© 1986 by The University of Chicago. All rights reserved. 003 1-5982/86/2932/$0 1 .00 S178 I Baruj Benaceraff ¦ Glorious Days ofCelluhr Immunology mense progress has only been possible because of the dedicated collaboration of numerous laboratories in the United States and abroad. This collaboration was cemented by the training of young scientists from abroad in our laboratories and vice versa. I have been fortunate to have contributed in a small measure to this process. On my discharge from the army in 1949, 1 began my scientific training in Elvin Rabat's laboratory, where I spent 2 years learning immunochemistry and where, more importantly, I was properly impressed with the true meaning ofaccuracy, the respect for scientific data, and the importance of intellectual integrity. This is the message that I have endeavored to pass on to my own students—I believe successfully. It is fair to recall that, at the time, I was the only one in the laboratory with a foreign background and that I was supported by my own personal resources , or, as Elvin aptly put it, I was on a Benacerraf fellowship. Leaving Rabat's laboratory I spent 6 years in France sponsored by the French CNRS, working in close, happy, and productive collaboration with a remarkable Italian scientist, Guido Biozzi. But I then realized that my work required that I return to the United States to establish my own laboratory of immunology. This opportunity was given me in 1956 by the generous offer from Lewis Thomas tojoin his department of pathology at New York University. The acceptance of this offer is probably the most important decision that I made in my scientific career. Lewis Thomas was an enlightened and charismatic chairman, and he ensured that the policies in the department would favor the unhindered and spectacular development of immunology that characterized the next 12 years at NYU. These were indeed golden years for immunology at NYU, and particularly for cellular immunology. In 1957, as I was looking for a technician for my laboratory, a young Hungarian refugee from the recent Budapest uprising presented herself , Martha Sebestyen. She hadjust graduated from medical school and was looking forward to a career in research. I hired her as my first research fellow rather than as a technician. Martha is now professor of clinical immunology at the University of Vienna. The first three years of my work..." @default.
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• W2023230738 date "1986-01-01" @default.
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• W2023230738 title "The Glorious Days of Cellular Immunology: New York University Years and Beyond, an International Experience" @default.
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• W2023230738 doi "https://doi.org/10.1353/pbm.1986.0015" @default.
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