FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2023231447> ?p ?o ?g. }

• W2023231447 endingPage "88" @default.
• W2023231447 startingPage "81" @default.
• W2023231447 abstract "Model systems to study the effects of chemicals of environmental concern on bacterial and parasitic diseases as well as the immunosurveillance and destruction of transplantable tumor cells were described and evaluated. Studies were conducted in female B6C3F1 mice following adult or pre/postnatal exposure to several prototype chemicals. The prototype chemicals employed included the synthetic estrogen diethylstilbestrol (DES), the polycyclic aromatic hydrocarbon benzo(a)pyrene (B[a]P), and the carcinogenesis promoting agent 12-0-tetradecanoyl-phorbol-13-0-acetate (TPA).The host resistance models employed depend primarily on functional thymus-dependent immunity, although humoral immunity is suggested to have a role in the parasite model as well. These models include: subcutaneous challenge with a dose of PYB6 tumor cell causing a 10-20% incidence (TD10–20) of tumor; intravenous challenge with B16 melanoma cells; challenge with a dose of Listeria monocytogenes causing a 10-20% incidence of mortality (LD10–20); challenge with a dose of E. coli lipopolysaccharide endotoxin causing a 10-20% incidence of lethality (LD10–20); and challenge with larvae of Trichinella spiralis for parasite expulsion kinetic studies.Increased mortality was observed following Listeria monocytogenes challenge in DES-exposed mice. B(a)P and TPA exposure did not alter host resistance to this organism. The increased mortality observed following DES was associated with a significant increase in the number of viable Listeria in the spleens and livers at 4 days, a time when T-cell immunity is thought to be expressed, but bacterial counts were similar to control mice at day 1, a time when MΦ are thought to exert their greatest effect. These data suggest that the increased Listeria susceptibility found following DES exposure may result from a T-cell defect, although the intracellular killing capacity of DES-treated Mϕ's has not been well examined.Tumor susceptibility studies following challenge with 5 × 103 viable syngeneic PYB6 tumor cells revealed that nontreated adult B6C3F1 mice resisted tumor formation, with only a 10-20% incidence of tumor formation. In contrast, mice exposed to DES or TPA as adults had a tumor frequency of from 70-100% following TPA and up to 90% following DES exposure. In all cases the tumors were progressive and resulted in death. B(a)P did not alter the frequency of tumor incidence from controls in this model.Preliminary data, using the B16 melanoma intravenous challenge model and 125IUdR to quantitate tumor mass revealed this model was sensitive to non-specifically activated macrophage kill. DES treated mice with activated macrophages did not demonstrate increased tumor mass, while mice exposed to TPA or the potent immunosuppressive agent cyclophosphamide had a significantly increased tumor mass in their lungs.Expulsion of Trichinella spiralis adults from the gut also apparently required functional T-cells and possibly some element of humoral immunity. Mice exposed to DES and B(a)P exhibited increased numbers of adult worms in the gut at day 14.Sensitivity to gram-negative endotoxin (LPS) was apparently increased following exposure to DES or B(a)P. These data suggest that the detoxification of LPS is related to an intact Mϕ population. The data presented here demonstrate the sensitivity of the host resistance assay panel proposed for detecting immune alteration. Alteration of T-cell function appeared to correlate with increased susceptibility to bacterial and tumor cell challenge." @default.
• W2023231447 created "2016-06-24" @default.
• W2023231447 creator A5010049315 @default.
• W2023231447 creator A5031239534 @default.
• W2023231447 creator A5033258217 @default.
• W2023231447 creator A5041052346 @default.
• W2023231447 creator A5052670791 @default.
• W2023231447 date "1982-02-01" @default.
• W2023231447 modified "2023-09-29" @default.
• W2023231447 title "Application of tumor, bacterial and parasite susceptibility assays to study immune alterations induced by environmental chemicals" @default.
• W2023231447 cites W1483194800 @default.
• W2023231447 cites W1525521815 @default.
• W2023231447 cites W1543964564 @default.
• W2023231447 cites W1561969582 @default.
• W2023231447 cites W1582758643 @default.
• W2023231447 cites W1583703594 @default.
• W2023231447 cites W1588053635 @default.
• W2023231447 cites W1591235653 @default.
• W2023231447 cites W1906995089 @default.
• W2023231447 cites W1915027955 @default.
• W2023231447 cites W1937067786 @default.
• W2023231447 cites W1967695611 @default.
• W2023231447 cites W1976099480 @default.
• W2023231447 cites W1987525776 @default.
• W2023231447 cites W2003080472 @default.
• W2023231447 cites W2009488257 @default.
• W2023231447 cites W2011176464 @default.
• W2023231447 cites W2026372077 @default.
• W2023231447 cites W2035323674 @default.
• W2023231447 cites W2037014848 @default.
• W2023231447 cites W2044501525 @default.
• W2023231447 cites W2045054061 @default.
• W2023231447 cites W2058824649 @default.
• W2023231447 cites W2062725277 @default.
• W2023231447 cites W2071458317 @default.
• W2023231447 cites W2071803002 @default.
• W2023231447 cites W2102916120 @default.
• W2023231447 cites W2109978524 @default.
• W2023231447 cites W2163890257 @default.
• W2023231447 cites W2164078454 @default.
• W2023231447 cites W2320210509 @default.
• W2023231447 cites W2330604059 @default.
• W2023231447 cites W2399546723 @default.
• W2023231447 cites W2410140803 @default.
• W2023231447 cites W2413923670 @default.
• W2023231447 cites W2412400001 @default.
• W2023231447 cites W2474843600 @default.
• W2023231447 doi "https://doi.org/10.1289/ehp.824381" @default.
• W2023231447 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/1568897" @default.
• W2023231447 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/7060548" @default.
• W2023231447 hasPublicationYear "1982" @default.
• W2023231447 type Work @default.
• W2023231447 sameAs 2023231447 @default.
• W2023231447 citedByCount "33" @default.
• W2023231447 countsByYear W20232314472012 @default.
• W2023231447 countsByYear W20232314472014 @default.
• W2023231447 countsByYear W20232314472017 @default.
• W2023231447 crossrefType "journal-article" @default.
• W2023231447 hasAuthorship W2023231447A5010049315 @default.
• W2023231447 hasAuthorship W2023231447A5031239534 @default.
• W2023231447 hasAuthorship W2023231447A5033258217 @default.
• W2023231447 hasAuthorship W2023231447A5041052346 @default.
• W2023231447 hasAuthorship W2023231447A5052670791 @default.
• W2023231447 hasBestOaLocation W20232314471 @default.
• W2023231447 hasConcept C203014093 @default.
• W2023231447 hasConcept C2776885095 @default.
• W2023231447 hasConcept C2777164284 @default.
• W2023231447 hasConcept C2777187800 @default.
• W2023231447 hasConcept C2778682378 @default.
• W2023231447 hasConcept C2779341262 @default.
• W2023231447 hasConcept C2781350384 @default.
• W2023231447 hasConcept C2781397067 @default.
• W2023231447 hasConcept C523546767 @default.
• W2023231447 hasConcept C54355233 @default.
• W2023231447 hasConcept C86803240 @default.
• W2023231447 hasConcept C8891405 @default.
• W2023231447 hasConcept C89423630 @default.
• W2023231447 hasConceptScore W2023231447C203014093 @default.
• W2023231447 hasConceptScore W2023231447C2776885095 @default.
• W2023231447 hasConceptScore W2023231447C2777164284 @default.
• W2023231447 hasConceptScore W2023231447C2777187800 @default.
• W2023231447 hasConceptScore W2023231447C2778682378 @default.
• W2023231447 hasConceptScore W2023231447C2779341262 @default.
• W2023231447 hasConceptScore W2023231447C2781350384 @default.
• W2023231447 hasConceptScore W2023231447C2781397067 @default.
• W2023231447 hasConceptScore W2023231447C523546767 @default.
• W2023231447 hasConceptScore W2023231447C54355233 @default.
• W2023231447 hasConceptScore W2023231447C86803240 @default.
• W2023231447 hasConceptScore W2023231447C8891405 @default.
• W2023231447 hasConceptScore W2023231447C89423630 @default.
• W2023231447 hasLocation W20232314471 @default.
• W2023231447 hasLocation W20232314472 @default.
• W2023231447 hasLocation W20232314473 @default.
• W2023231447 hasLocation W20232314474 @default.
• W2023231447 hasOpenAccess W2023231447 @default.
• W2023231447 hasPrimaryLocation W20232314471 @default.
• W2023231447 hasRelatedWork W1459178884 @default.
• W2023231447 hasRelatedWork W1570201687 @default.

• next