Matches in SemOpenAlex for { <https://semopenalex.org/work/W2023231603> ?p ?o ?g. }
Showing items 1 to 80 of
80
with 100 items per page.
- W2023231603 endingPage "7164" @default.
- W2023231603 startingPage "7158" @default.
- W2023231603 abstract "Nucleotide excision repair (NER) is an important cellular mechanism that removes radiation-induced and chemically induced damage from DNA. The XPA protein is involved in the damage recognition step of NER and appears to function by binding damaged DNA and recruiting other proteins to the site. It may also play a role in subsequent steps of NER through interaction with other repair proteins. Interstrand cross-links are of particular interest, since these lesions involve both strands of duplex DNA and present special challenges to the repair machinery. Using 14 and 25 bp duplex oligonucleotides containing a defined, well-characterized single mitomycin C (MMC)-DNA interstrand cross-link, we have shown through gel shift analysis that both XPA and a minimal DNA binding domain of XPA (XPA-MF122) preferentially bind to MMC-cross-linked DNA with a greater specificity and a higher affinity (>2-fold) than to the same undamaged DNA sequence. This preferential binding to MMC-cross-linked DNA occurs in the absence of other proteins from the NER complex. Differences in binding affinity and specificity were observed among the different protein-DNA combinations that were both protein and DNA specific. Defining XPA-MMC-DNA interactions may aid in elucidating the mechanism by which DNA cross-links and other forms of DNA damage are recognized and repaired by the NER machinery in eukaryotic cells." @default.
- W2023231603 created "2016-06-24" @default.
- W2023231603 creator A5014098586 @default.
- W2023231603 creator A5061349538 @default.
- W2023231603 creator A5071177646 @default.
- W2023231603 date "2001-05-19" @default.
- W2023231603 modified "2023-10-02" @default.
- W2023231603 title "Preferential Binding of Human Full-Length XPA and the Minimal DNA Binding Domain (XPA-MF122) with the Mitomycin C−DNA Interstrand Cross-Link" @default.
- W2023231603 cites W12794080 @default.
- W2023231603 cites W1956254450 @default.
- W2023231603 cites W1980686795 @default.
- W2023231603 cites W1995021789 @default.
- W2023231603 cites W1999104040 @default.
- W2023231603 cites W2006824703 @default.
- W2023231603 cites W2020651808 @default.
- W2023231603 cites W2025855205 @default.
- W2023231603 cites W2091566576 @default.
- W2023231603 doi "https://doi.org/10.1021/bi002820u" @default.
- W2023231603 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/11401562" @default.
- W2023231603 hasPublicationYear "2001" @default.
- W2023231603 type Work @default.
- W2023231603 sameAs 2023231603 @default.
- W2023231603 citedByCount "10" @default.
- W2023231603 countsByYear W20232316032012 @default.
- W2023231603 crossrefType "journal-article" @default.
- W2023231603 hasAuthorship W2023231603A5014098586 @default.
- W2023231603 hasAuthorship W2023231603A5061349538 @default.
- W2023231603 hasAuthorship W2023231603A5071177646 @default.
- W2023231603 hasConcept C104317684 @default.
- W2023231603 hasConcept C104451858 @default.
- W2023231603 hasConcept C113271649 @default.
- W2023231603 hasConcept C129312508 @default.
- W2023231603 hasConcept C134935766 @default.
- W2023231603 hasConcept C153911025 @default.
- W2023231603 hasConcept C156719811 @default.
- W2023231603 hasConcept C31254050 @default.
- W2023231603 hasConcept C5179208 @default.
- W2023231603 hasConcept C552990157 @default.
- W2023231603 hasConcept C55493867 @default.
- W2023231603 hasConcept C67705224 @default.
- W2023231603 hasConcept C86339819 @default.
- W2023231603 hasConcept C86803240 @default.
- W2023231603 hasConcept C94966510 @default.
- W2023231603 hasConceptScore W2023231603C104317684 @default.
- W2023231603 hasConceptScore W2023231603C104451858 @default.
- W2023231603 hasConceptScore W2023231603C113271649 @default.
- W2023231603 hasConceptScore W2023231603C129312508 @default.
- W2023231603 hasConceptScore W2023231603C134935766 @default.
- W2023231603 hasConceptScore W2023231603C153911025 @default.
- W2023231603 hasConceptScore W2023231603C156719811 @default.
- W2023231603 hasConceptScore W2023231603C31254050 @default.
- W2023231603 hasConceptScore W2023231603C5179208 @default.
- W2023231603 hasConceptScore W2023231603C552990157 @default.
- W2023231603 hasConceptScore W2023231603C55493867 @default.
- W2023231603 hasConceptScore W2023231603C67705224 @default.
- W2023231603 hasConceptScore W2023231603C86339819 @default.
- W2023231603 hasConceptScore W2023231603C86803240 @default.
- W2023231603 hasConceptScore W2023231603C94966510 @default.
- W2023231603 hasIssue "24" @default.
- W2023231603 hasLocation W20232316031 @default.
- W2023231603 hasLocation W20232316032 @default.
- W2023231603 hasOpenAccess W2023231603 @default.
- W2023231603 hasPrimaryLocation W20232316031 @default.
- W2023231603 hasRelatedWork W1746630368 @default.
- W2023231603 hasRelatedWork W2023231603 @default.
- W2023231603 hasRelatedWork W2024434976 @default.
- W2023231603 hasRelatedWork W2027852452 @default.
- W2023231603 hasRelatedWork W2051402439 @default.
- W2023231603 hasRelatedWork W2053929263 @default.
- W2023231603 hasRelatedWork W2065965425 @default.
- W2023231603 hasRelatedWork W2106334971 @default.
- W2023231603 hasRelatedWork W2122753398 @default.
- W2023231603 hasRelatedWork W2127149431 @default.
- W2023231603 hasVolume "40" @default.
- W2023231603 isParatext "false" @default.
- W2023231603 isRetracted "false" @default.
- W2023231603 magId "2023231603" @default.
- W2023231603 workType "article" @default.