Matches in SemOpenAlex for { <https://semopenalex.org/work/W2023233268> ?p ?o ?g. }
Showing items 1 to 81 of
81
with 100 items per page.
- W2023233268 endingPage "214" @default.
- W2023233268 startingPage "207" @default.
- W2023233268 abstract "Oncolytic viruses are examined to serve as anticancer therapeutics. It is expected that in addition to direct oncolytic effect their action will also help eliciting a solid antitumor immunity. In presented series of experiments we have employed two HPV16-transformed mouse (strain C57/B6) cell lines, TC-1 and MK16/III/ABC (MK16), and reovirus type 3, strain Dearing (RV). Both cell lines are highly susceptible to RV and produce large amounts of infectious virus in vitro while normal human are not susceptible to RV. Still, some differences were encountered. TC-1 cells produced moderately lesser amounts of infectious virus, but, paradoxically, were more efficient producers of delta1 antigen of RV and as a consequence of virus infection died more rapidly than simultaneously infected MK16 cells. Minor differences between the cell lines were observed in the percentage of cells arrested in theG2/M phase of the cell cycle and in some markers of apoptosis. When inoculating high doses (5x106) of infected cells (MOI 10 PFU/cell) into syngeneic animals their oncogenic activity was strongly suppressed, nearly completely in the case of MK16 cells and somewhat less efficiently in the case of more oncogenic TC-1 cells. Immunizing experiments in which non-oncogenic doses (106) of RV infected TC-1 cells were tested in parallel with the same doses of irradiated cells brought surprising results. When immunized animals were challenged with TC-1 cells, the irradiated cells proved to be a much better immunogen that the infected cells. However, when challenged with MK16 cells the opposite was true. It is believed that this difference was associated with the different biological properties of the cell lines tested.reovirus type 3, HPV16-transformed mouse cell lines, apoptosis, cell cycle, immunization/challenge experiments." @default.
- W2023233268 created "2016-06-24" @default.
- W2023233268 creator A5007889827 @default.
- W2023233268 creator A5013532796 @default.
- W2023233268 creator A5013742468 @default.
- W2023233268 creator A5029914494 @default.
- W2023233268 creator A5030247824 @default.
- W2023233268 creator A5060910371 @default.
- W2023233268 date "2010-01-01" @default.
- W2023233268 modified "2023-09-23" @default.
- W2023233268 title "In vitro and in vivo effects of reovirus on HPV16-transformed mice cells" @default.
- W2023233268 doi "https://doi.org/10.4149/neo_2010_03_207" @default.
- W2023233268 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/20353270" @default.
- W2023233268 hasPublicationYear "2010" @default.
- W2023233268 type Work @default.
- W2023233268 sameAs 2023233268 @default.
- W2023233268 citedByCount "1" @default.
- W2023233268 countsByYear W20232332682016 @default.
- W2023233268 crossrefType "journal-article" @default.
- W2023233268 hasAuthorship W2023233268A5007889827 @default.
- W2023233268 hasAuthorship W2023233268A5013532796 @default.
- W2023233268 hasAuthorship W2023233268A5013742468 @default.
- W2023233268 hasAuthorship W2023233268A5029914494 @default.
- W2023233268 hasAuthorship W2023233268A5030247824 @default.
- W2023233268 hasAuthorship W2023233268A5060910371 @default.
- W2023233268 hasConcept C1491633281 @default.
- W2023233268 hasConcept C150903083 @default.
- W2023233268 hasConcept C153911025 @default.
- W2023233268 hasConcept C159047783 @default.
- W2023233268 hasConcept C159654299 @default.
- W2023233268 hasConcept C190283241 @default.
- W2023233268 hasConcept C202751555 @default.
- W2023233268 hasConcept C203014093 @default.
- W2023233268 hasConcept C207001950 @default.
- W2023233268 hasConcept C2522874641 @default.
- W2023233268 hasConcept C2779909307 @default.
- W2023233268 hasConcept C542903549 @default.
- W2023233268 hasConcept C54355233 @default.
- W2023233268 hasConcept C55493867 @default.
- W2023233268 hasConcept C81885089 @default.
- W2023233268 hasConcept C82210918 @default.
- W2023233268 hasConcept C86803240 @default.
- W2023233268 hasConceptScore W2023233268C1491633281 @default.
- W2023233268 hasConceptScore W2023233268C150903083 @default.
- W2023233268 hasConceptScore W2023233268C153911025 @default.
- W2023233268 hasConceptScore W2023233268C159047783 @default.
- W2023233268 hasConceptScore W2023233268C159654299 @default.
- W2023233268 hasConceptScore W2023233268C190283241 @default.
- W2023233268 hasConceptScore W2023233268C202751555 @default.
- W2023233268 hasConceptScore W2023233268C203014093 @default.
- W2023233268 hasConceptScore W2023233268C207001950 @default.
- W2023233268 hasConceptScore W2023233268C2522874641 @default.
- W2023233268 hasConceptScore W2023233268C2779909307 @default.
- W2023233268 hasConceptScore W2023233268C542903549 @default.
- W2023233268 hasConceptScore W2023233268C54355233 @default.
- W2023233268 hasConceptScore W2023233268C55493867 @default.
- W2023233268 hasConceptScore W2023233268C81885089 @default.
- W2023233268 hasConceptScore W2023233268C82210918 @default.
- W2023233268 hasConceptScore W2023233268C86803240 @default.
- W2023233268 hasIssue "3" @default.
- W2023233268 hasLocation W20232332681 @default.
- W2023233268 hasLocation W20232332682 @default.
- W2023233268 hasOpenAccess W2023233268 @default.
- W2023233268 hasPrimaryLocation W20232332681 @default.
- W2023233268 hasRelatedWork W1991126365 @default.
- W2023233268 hasRelatedWork W1996057531 @default.
- W2023233268 hasRelatedWork W2006312942 @default.
- W2023233268 hasRelatedWork W2020692772 @default.
- W2023233268 hasRelatedWork W2021255975 @default.
- W2023233268 hasRelatedWork W2042835129 @default.
- W2023233268 hasRelatedWork W2099619575 @default.
- W2023233268 hasRelatedWork W2464301138 @default.
- W2023233268 hasRelatedWork W4214529253 @default.
- W2023233268 hasRelatedWork W4252778473 @default.
- W2023233268 hasVolume "57" @default.
- W2023233268 isParatext "false" @default.
- W2023233268 isRetracted "false" @default.
- W2023233268 magId "2023233268" @default.
- W2023233268 workType "article" @default.