FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2023235628> ?p ?o ?g. }

• W2023235628 endingPage "382" @default.
• W2023235628 startingPage "375" @default.
• W2023235628 abstract "The endocannabinoid system (ECS) consists of two receptors (CB(1) and CB(2)), several endogenous ligands (primarily anandamide and 2-AG), and over a dozen ligand-metabolizing enzymes. The ECS regulates many aspects of embryological development and homeostasis, including neuroprotection and neural plasticity, immunity and inflammation, apoptosis and carcinogenesis, pain and emotional memory, and the focus of this review: hunger, feeding, and metabolism. This mini-review summarizes the main findings that supported the clinical use of CB1 antagonists/inverse agonists, the clinical concerns that have emerged, and the possible future of cannabinoid-based therapy of obesity and related diseases. The ECS controls energy balance and lipid metabolism centrally (in the hypothalamus and mesolimbic pathways) and peripherally (in adipocytes, liver, skeletal muscle and pancreatic islet cells), acting through numerous anorexigenic and orexigenic pathways. Obese people seem to display an increased endocannabinoid tone, driving CB(1) receptor in a feed-forward dysfunction. Several CB(1) antagonists/inverse agonists have been developed for the treatment of obesity. Although these drugs were found to be efficacious at reducing food intake as well as abdominal adiposity and cardiometabolic risk factors, they resulted in adverse psychiatric effects that limited their use and finally led to the end of the clinical use of systemic CB(1) ligands with significant inverse agonist activity for complicated obesity. However, the existence of alternatives such as CB(1) partial agonists, neutral antagonists, antagonists restricted to the periphery, allosteric modulators and other potential targets within the ECS indicate that a cannabinoid-based therapy for the management of obesity and its associated cardiometabolic sequelae should remain open for consideration." @default.
• W2023235628 created "2016-06-24" @default.
• W2023235628 creator A5014291973 @default.
• W2023235628 creator A5024294784 @default.
• W2023235628 creator A5063603806 @default.
• W2023235628 creator A5072221288 @default.
• W2023235628 date "2010-06-01" @default.
• W2023235628 modified "2023-10-17" @default.
• W2023235628 title "The endocannabinoid system, eating behavior and energy homeostasis: The end or a new beginning?" @default.
• W2023235628 cites W1491109154 @default.
• W2023235628 cites W1508039321 @default.
• W2023235628 cites W1584158731 @default.
• W2023235628 cites W1880519341 @default.
• W2023235628 cites W1963482720 @default.
• W2023235628 cites W1966146877 @default.
• W2023235628 cites W1967922769 @default.
• W2023235628 cites W1970504819 @default.
• W2023235628 cites W1971698096 @default.
• W2023235628 cites W1975173051 @default.
• W2023235628 cites W1981748148 @default.
• W2023235628 cites W1982538469 @default.
• W2023235628 cites W1984089454 @default.
• W2023235628 cites W1984645352 @default.
• W2023235628 cites W1987679951 @default.
• W2023235628 cites W1991778481 @default.
• W2023235628 cites W1992655222 @default.
• W2023235628 cites W1992804100 @default.
• W2023235628 cites W1995734772 @default.
• W2023235628 cites W1996536154 @default.
• W2023235628 cites W1999808927 @default.
• W2023235628 cites W2003425100 @default.
• W2023235628 cites W2005136472 @default.
• W2023235628 cites W2013159548 @default.
• W2023235628 cites W2013623792 @default.
• W2023235628 cites W2016017780 @default.
• W2023235628 cites W2016034906 @default.
• W2023235628 cites W2016821576 @default.
• W2023235628 cites W2021216066 @default.
• W2023235628 cites W2022514673 @default.
• W2023235628 cites W2023077982 @default.
• W2023235628 cites W2029820981 @default.
• W2023235628 cites W2031498785 @default.
• W2023235628 cites W2033818328 @default.
• W2023235628 cites W2035159731 @default.
• W2023235628 cites W2037412847 @default.
• W2023235628 cites W2037457092 @default.
• W2023235628 cites W2038667563 @default.
• W2023235628 cites W2039598436 @default.
• W2023235628 cites W2040133753 @default.
• W2023235628 cites W2043356587 @default.
• W2023235628 cites W2044456340 @default.
• W2023235628 cites W2057349855 @default.
• W2023235628 cites W2058027456 @default.
• W2023235628 cites W2062170088 @default.
• W2023235628 cites W2066984661 @default.
• W2023235628 cites W2067294765 @default.
• W2023235628 cites W2068939963 @default.
• W2023235628 cites W2069967676 @default.
• W2023235628 cites W2071904759 @default.
• W2023235628 cites W2073734463 @default.
• W2023235628 cites W2075237064 @default.
• W2023235628 cites W2079624589 @default.
• W2023235628 cites W2080649553 @default.
• W2023235628 cites W2084821051 @default.
• W2023235628 cites W2084882002 @default.
• W2023235628 cites W2087587748 @default.
• W2023235628 cites W2091315563 @default.
• W2023235628 cites W2094313031 @default.
• W2023235628 cites W2097679599 @default.
• W2023235628 cites W2106607972 @default.
• W2023235628 cites W2112924959 @default.
• W2023235628 cites W2114635026 @default.
• W2023235628 cites W2116322199 @default.
• W2023235628 cites W2118147078 @default.
• W2023235628 cites W2123907272 @default.
• W2023235628 cites W2126940436 @default.
• W2023235628 cites W2127310430 @default.
• W2023235628 cites W2128894123 @default.
• W2023235628 cites W2133628981 @default.
• W2023235628 cites W2133811076 @default.
• W2023235628 cites W2136160086 @default.
• W2023235628 cites W2136980094 @default.
• W2023235628 cites W2139294235 @default.
• W2023235628 cites W2143941489 @default.
• W2023235628 cites W2146709170 @default.
• W2023235628 cites W2151669647 @default.
• W2023235628 cites W2165284792 @default.
• W2023235628 cites W2166773738 @default.
• W2023235628 cites W2168128112 @default.
• W2023235628 cites W2171903032 @default.
• W2023235628 cites W2324311973 @default.
• W2023235628 cites W2994265892 @default.
• W2023235628 cites W98112236 @default.
• W2023235628 doi "https://doi.org/10.1016/j.pbb.2010.03.012" @default.
• W2023235628 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/20347862" @default.
• W2023235628 hasPublicationYear "2010" @default.
• W2023235628 type Work @default.
• W2023235628 sameAs 2023235628 @default.

• next