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- W2023235669 abstract "Chelating agents have been used clinically as antidotes for acute and chronic metal intoxications. These compounds not only enhance excretion but, in at least some cases, they also decrease the metal’s toxicity by preventing it from binding to cellular target molecules (Aposhian et al. 1995). Conversely, prolonged treatment with a chelating agent may lead to haematopoietic disorders (Flora & Kumar 1993), impairment of cellular metabolism, and synthesis of DNA, RNA and protein (Fischer et al. 1975), or trace element imbalance (Cantilena & Klaassen 1982). One of these metal chelators, 2,3-dimercaptopropanol (BAL), has the capacity to ameliorate the deleterious effects of metals intoxications, but it has a low therapeutic index (Andersen 1989). Despite relevant evidence of the BAL therapeutic use, obtained from in vivo and in vitro animal data as well as clinical accounts, its use as treatment for poisoning has been halted by data suggesting serious neurotoxicity (Pepin et al. 1995; Nogueira et al. 2000, 2001a&b). Other chelating agents, such as 2,3-dimercapto-1-propanesulfonic acid (DMPS, DimavalA) and meso-2,3-dimercaptosuccinic acid (DMSA, succimer) are less toxic and more effective chelating agents than the chemically analogous BAL (Aposhian et al. 1995). DMPS is registered in Germany for the treatment of mercury intoxication (Clarkson et al. 1981) or lead poisoning in children and adults (Kemper et al. 1990). Clinical reliance on DMSA, an orally administered chelating, has expanded greatly during the last years particularly after its approval for the clinical use against childhood lead poisoning by US Food and Drug Administration (FDA) (Jorgensen 1993). In the present investigation a number of toxicological par-" @default.
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- W2023235669 date "2005-04-01" @default.
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- W2023235669 title "2,3-Dimercaptopropanol, 2,3-Dimercaptopropane-1-sulfonic Acid and meso-2,3-Dimercaptosuccinic Acid Acute Administration Diferentially Change Biochemical Parameters in Mice" @default.
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- W2023235669 doi "https://doi.org/10.1111/j.1742-7843.2005.pto960409.x" @default.
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