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• W2023236906 endingPage "257" @default.
• W2023236906 startingPage "247" @default.
• W2023236906 abstract "Abstract Conventional wisdom presumes that the α7nAChR product of CHRNA7 expression mediates the ability of the vagus nerve to regulate the inflammatory response to injury and infection. Yet, 15 years ago, a 2nd structurally distinct and human-specific α7nAChR gene was discovered that has largely escaped attention of the inflammation research community. The gene, originally called dupα7nAChR but now known as CHRFAM7A, has been studied exhaustively in psychiatric research because of its association with mental illness. However, dupα7nAChR/CHRFAM7A expression is relatively low in human brain but elevated in human leukocytes. Furthermore, α7nAChR research in human tissues has been confounded by cross-reacting antibodies and nonspecific oligonucleotide primers that crossreact in immunoblotting, immunohistochemistry, and RT-PCR. Yet, 3 independent reports show the human-specific CHRFAM7A changes cell responsiveness to the canonical α7nAChR/CHRNA7 ion-gated channel. Because of its potential for the injury research community, its possible significance to human leukocyte biology, and its relevance to human inflammation, we review the discovery and structure of the dupα7nAChR/CHRFAM7A gene, the distribution of its mRNA, and its biologic activities and then discuss its possible role(s) in specifying human inflammation and injury. In light of emerging concepts that point to a role for human-specific genes in complex human disease, the existence of a human-specific α7nAChR regulating inflammatory responses in injury underscores the need for caution in extrapolating findings in the α7nAChR literature to man. To this end, we discuss the translational implications of a uniquely human α7nAChR-like gene on new drug target discovery and therapeutics development for injury, infection, and inflammation." @default.
• W2023236906 created "2016-06-24" @default.
• W2023236906 creator A5001537127 @default.
• W2023236906 creator A5002367283 @default.
• W2023236906 creator A5024786945 @default.
• W2023236906 creator A5037880923 @default.
• W2023236906 creator A5065355429 @default.
• W2023236906 date "2014-12-03" @default.
• W2023236906 modified "2023-10-12" @default.
• W2023236906 title "CHRFAM7A, a human-specific and partially duplicated <i>α</i>7-nicotinic acetylcholine receptor gene with the potential to specify a human-specific inflammatory response to injury" @default.
• W2023236906 cites W1543265920 @default.
• W2023236906 cites W1569567729 @default.
• W2023236906 cites W1577070562 @default.
• W2023236906 cites W1594018550 @default.
• W2023236906 cites W1849251200 @default.
• W2023236906 cites W1891078220 @default.
• W2023236906 cites W1900806927 @default.
• W2023236906 cites W1901457319 @default.
• W2023236906 cites W1906312058 @default.
• W2023236906 cites W1936852202 @default.
• W2023236906 cites W1966256304 @default.
• W2023236906 cites W1971784543 @default.
• W2023236906 cites W1972981785 @default.
• W2023236906 cites W1974828453 @default.
• W2023236906 cites W1975622213 @default.
• W2023236906 cites W1981020037 @default.
• W2023236906 cites W1982171918 @default.
• W2023236906 cites W1984727828 @default.
• W2023236906 cites W1985426472 @default.
• W2023236906 cites W1986356926 @default.
• W2023236906 cites W1991949383 @default.
• W2023236906 cites W1992428903 @default.
• W2023236906 cites W1993133636 @default.
• W2023236906 cites W1995260110 @default.
• W2023236906 cites W1995525413 @default.
• W2023236906 cites W1995795987 @default.
• W2023236906 cites W1996121363 @default.
• W2023236906 cites W1996162797 @default.
• W2023236906 cites W1999542553 @default.
• W2023236906 cites W2002612339 @default.
• W2023236906 cites W2002797282 @default.
• W2023236906 cites W2003298566 @default.
• W2023236906 cites W2005860295 @default.
• W2023236906 cites W2006097588 @default.
• W2023236906 cites W2007143131 @default.
• W2023236906 cites W2013032695 @default.
• W2023236906 cites W2013717623 @default.
• W2023236906 cites W2023499236 @default.
• W2023236906 cites W2024477403 @default.
• W2023236906 cites W2024632436 @default.
• W2023236906 cites W2026208410 @default.
• W2023236906 cites W2027265512 @default.
• W2023236906 cites W2027337530 @default.
• W2023236906 cites W2029051866 @default.
• W2023236906 cites W2029794340 @default.
• W2023236906 cites W2034035509 @default.
• W2023236906 cites W2038313235 @default.
• W2023236906 cites W2043470688 @default.
• W2023236906 cites W2046407626 @default.
• W2023236906 cites W2046465350 @default.
• W2023236906 cites W2046775696 @default.
• W2023236906 cites W2047658647 @default.
• W2023236906 cites W2049672050 @default.
• W2023236906 cites W2050221047 @default.
• W2023236906 cites W2059787600 @default.
• W2023236906 cites W2059805279 @default.
• W2023236906 cites W2063270148 @default.
• W2023236906 cites W2067513312 @default.
• W2023236906 cites W2072807117 @default.
• W2023236906 cites W2073295417 @default.
• W2023236906 cites W2074617527 @default.
• W2023236906 cites W2074834514 @default.
• W2023236906 cites W2074946798 @default.
• W2023236906 cites W2075323804 @default.
• W2023236906 cites W2076108966 @default.
• W2023236906 cites W2079212663 @default.
• W2023236906 cites W2081852021 @default.
• W2023236906 cites W2083230300 @default.
• W2023236906 cites W2086946889 @default.
• W2023236906 cites W2088201027 @default.
• W2023236906 cites W2095907724 @default.
• W2023236906 cites W2095948686 @default.
• W2023236906 cites W2097364950 @default.
• W2023236906 cites W2099014340 @default.
• W2023236906 cites W2099514319 @default.
• W2023236906 cites W2110332338 @default.
• W2023236906 cites W2114913664 @default.
• W2023236906 cites W2115902309 @default.
• W2023236906 cites W2118881803 @default.
• W2023236906 cites W2121703596 @default.
• W2023236906 cites W2121720045 @default.
• W2023236906 cites W2124560890 @default.
• W2023236906 cites W2124599871 @default.
• W2023236906 cites W2128643990 @default.
• W2023236906 cites W2128845098 @default.
• W2023236906 cites W2133138650 @default.
• W2023236906 cites W2135507919 @default.
• W2023236906 cites W2139714151 @default.

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