Matches in SemOpenAlex for { <https://semopenalex.org/work/W2023238436> ?p ?o ?g. }
- W2023238436 endingPage "134" @default.
- W2023238436 startingPage "119" @default.
- W2023238436 abstract "The direct lineage reprogramming of one specialized cell type into another using defined factors has fundamentally re-shaped traditional concepts regarding the epigenetic stability of differentiated cells. With the rapid increase in cell types generated through direct conversion in recent years, this strategy has become a promising approach for producing functional cells. Here, we review recent advances in lineage reprogramming, including the identification of novel reprogramming factors, underlying molecular mechanisms, strategies for generating functionally mature cells, and assays for characterizing induced cells. We also discuss progress toward the application of lineage reprogramming and the major future challenges for this strategy. The direct lineage reprogramming of one specialized cell type into another using defined factors has fundamentally re-shaped traditional concepts regarding the epigenetic stability of differentiated cells. With the rapid increase in cell types generated through direct conversion in recent years, this strategy has become a promising approach for producing functional cells. Here, we review recent advances in lineage reprogramming, including the identification of novel reprogramming factors, underlying molecular mechanisms, strategies for generating functionally mature cells, and assays for characterizing induced cells. We also discuss progress toward the application of lineage reprogramming and the major future challenges for this strategy." @default.
- W2023238436 created "2016-06-24" @default.
- W2023238436 creator A5052971827 @default.
- W2023238436 creator A5065342163 @default.
- W2023238436 creator A5088259187 @default.
- W2023238436 date "2015-02-01" @default.
- W2023238436 modified "2023-10-06" @default.
- W2023238436 title "Direct Lineage Reprogramming: Strategies, Mechanisms, and Applications" @default.
- W2023238436 cites W1501304042 @default.
- W2023238436 cites W1587712169 @default.
- W2023238436 cites W1608762409 @default.
- W2023238436 cites W1933400321 @default.
- W2023238436 cites W1963745085 @default.
- W2023238436 cites W1964076580 @default.
- W2023238436 cites W1965378998 @default.
- W2023238436 cites W1966675386 @default.
- W2023238436 cites W1966969776 @default.
- W2023238436 cites W1967273423 @default.
- W2023238436 cites W1967729506 @default.
- W2023238436 cites W1968092893 @default.
- W2023238436 cites W1968310639 @default.
- W2023238436 cites W1968832732 @default.
- W2023238436 cites W1970339827 @default.
- W2023238436 cites W1970728400 @default.
- W2023238436 cites W1971553024 @default.
- W2023238436 cites W1971950783 @default.
- W2023238436 cites W1973876334 @default.
- W2023238436 cites W1974612283 @default.
- W2023238436 cites W1978337436 @default.
- W2023238436 cites W1979513200 @default.
- W2023238436 cites W1982220589 @default.
- W2023238436 cites W1986947784 @default.
- W2023238436 cites W1987167495 @default.
- W2023238436 cites W1987618226 @default.
- W2023238436 cites W1988146415 @default.
- W2023238436 cites W1991533533 @default.
- W2023238436 cites W1991664409 @default.
- W2023238436 cites W1994899810 @default.
- W2023238436 cites W1998167315 @default.
- W2023238436 cites W1999800789 @default.
- W2023238436 cites W2001356598 @default.
- W2023238436 cites W2001419937 @default.
- W2023238436 cites W2003459509 @default.
- W2023238436 cites W2005182538 @default.
- W2023238436 cites W2007439698 @default.
- W2023238436 cites W2008365696 @default.
- W2023238436 cites W2009876840 @default.
- W2023238436 cites W2010957709 @default.
- W2023238436 cites W2011747072 @default.
- W2023238436 cites W2013108229 @default.
- W2023238436 cites W2014429225 @default.
- W2023238436 cites W2015063977 @default.
- W2023238436 cites W2018392082 @default.
- W2023238436 cites W2019346039 @default.
- W2023238436 cites W2019525579 @default.
- W2023238436 cites W2022507430 @default.
- W2023238436 cites W2023025245 @default.
- W2023238436 cites W2023778684 @default.
- W2023238436 cites W2025899080 @default.
- W2023238436 cites W2027449023 @default.
- W2023238436 cites W2027703497 @default.
- W2023238436 cites W2028306551 @default.
- W2023238436 cites W2029353869 @default.
- W2023238436 cites W2031195065 @default.
- W2023238436 cites W2031285837 @default.
- W2023238436 cites W2033498063 @default.
- W2023238436 cites W2033500695 @default.
- W2023238436 cites W2037531698 @default.
- W2023238436 cites W2037572029 @default.
- W2023238436 cites W2038739068 @default.
- W2023238436 cites W2039028219 @default.
- W2023238436 cites W2041108404 @default.
- W2023238436 cites W2042699649 @default.
- W2023238436 cites W2043541084 @default.
- W2023238436 cites W2045269599 @default.
- W2023238436 cites W2045997356 @default.
- W2023238436 cites W2057641653 @default.
- W2023238436 cites W2057876838 @default.
- W2023238436 cites W2058051854 @default.
- W2023238436 cites W2058131133 @default.
- W2023238436 cites W2058553784 @default.
- W2023238436 cites W2061095282 @default.
- W2023238436 cites W2061632247 @default.
- W2023238436 cites W2061717797 @default.
- W2023238436 cites W2064015155 @default.
- W2023238436 cites W2064443141 @default.
- W2023238436 cites W2064692549 @default.
- W2023238436 cites W2065459869 @default.
- W2023238436 cites W2068326991 @default.
- W2023238436 cites W2068478010 @default.
- W2023238436 cites W2068677193 @default.
- W2023238436 cites W2069958858 @default.
- W2023238436 cites W2071134792 @default.
- W2023238436 cites W2072351477 @default.
- W2023238436 cites W2073660837 @default.
- W2023238436 cites W2075134815 @default.
- W2023238436 cites W2075887295 @default.
- W2023238436 cites W2076486071 @default.