FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2023238933> ?p ?o ?g. }

• W2023238933 endingPage "209" @default.
• W2023238933 startingPage "204" @default.
• W2023238933 abstract "Treatment with DAPT, an inhibitor of the Notch-activating enzyme, γ-secretase is known to reduce damage to ischemic brain. However, the molecular mechanisms supporting this therapeutic effect are not fully understood. Here we demonstrated that Notch/RBP-J signaling is activated in NG2+ glial progenitors and reactive astrocytes such as GFAP+ cells, Nestin+ cells and RC2+ cells, using Notch/RBP-J signaling reporter mice. 3-day DAPT treatment reduced the number of reactive astrocytes but not NG2+ glial progenitors. BrdU labeling experiments have shown that this reduction was due to decreased proliferation of reactive astrocytes. DAPT inhibited nuclear-translocation of Olig2, which is indispensable for proliferation and differentiation of reactive astrocytes. These findings suggest that Notch signaling might promote proliferation and differentiation of reactive astrocytes through the regulation of nucleo-cytoplasmic translocation of Olig2." @default.
• W2023238933 created "2016-06-24" @default.
• W2023238933 creator A5001222038 @default.
• W2023238933 creator A5013334721 @default.
• W2023238933 creator A5045027100 @default.
• W2023238933 creator A5059554216 @default.
• W2023238933 creator A5074071806 @default.
• W2023238933 creator A5079975386 @default.
• W2023238933 date "2013-03-01" @default.
• W2023238933 modified "2023-10-06" @default.
• W2023238933 title "Notch signaling regulates nucleocytoplasmic Olig2 translocation in reactive astrocytes differentiation after ischemic stroke" @default.
• W2023238933 cites W1919750748 @default.
• W2023238933 cites W1968614642 @default.
• W2023238933 cites W1988792859 @default.
• W2023238933 cites W1994859370 @default.
• W2023238933 cites W2022284098 @default.
• W2023238933 cites W2034597638 @default.
• W2023238933 cites W2039210066 @default.
• W2023238933 cites W2040141693 @default.
• W2023238933 cites W2040787182 @default.
• W2023238933 cites W2044363139 @default.
• W2023238933 cites W2045044865 @default.
• W2023238933 cites W2047804432 @default.
• W2023238933 cites W2056103140 @default.
• W2023238933 cites W2062084323 @default.
• W2023238933 cites W2063478423 @default.
• W2023238933 cites W2065569210 @default.
• W2023238933 cites W2067076482 @default.
• W2023238933 cites W2073390876 @default.
• W2023238933 cites W2076501672 @default.
• W2023238933 cites W2083647133 @default.
• W2023238933 cites W2084566588 @default.
• W2023238933 cites W2100100832 @default.
• W2023238933 cites W2104968232 @default.
• W2023238933 cites W2112505121 @default.
• W2023238933 cites W2112707259 @default.
• W2023238933 cites W2118159405 @default.
• W2023238933 cites W2118589362 @default.
• W2023238933 cites W2131443076 @default.
• W2023238933 cites W2156545134 @default.
• W2023238933 cites W2167582537 @default.
• W2023238933 doi "https://doi.org/10.1016/j.neures.2013.01.006" @default.
• W2023238933 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/23396245" @default.
• W2023238933 hasPublicationYear "2013" @default.
• W2023238933 type Work @default.
• W2023238933 sameAs 2023238933 @default.
• W2023238933 citedByCount "38" @default.
• W2023238933 countsByYear W20232389332013 @default.
• W2023238933 countsByYear W20232389332014 @default.
• W2023238933 countsByYear W20232389332015 @default.
• W2023238933 countsByYear W20232389332016 @default.
• W2023238933 countsByYear W20232389332017 @default.
• W2023238933 countsByYear W20232389332018 @default.
• W2023238933 countsByYear W20232389332019 @default.
• W2023238933 countsByYear W20232389332020 @default.
• W2023238933 countsByYear W20232389332021 @default.
• W2023238933 countsByYear W20232389332022 @default.
• W2023238933 countsByYear W20232389332023 @default.
• W2023238933 crossrefType "journal-article" @default.
• W2023238933 hasAuthorship W2023238933A5001222038 @default.
• W2023238933 hasAuthorship W2023238933A5013334721 @default.
• W2023238933 hasAuthorship W2023238933A5045027100 @default.
• W2023238933 hasAuthorship W2023238933A5059554216 @default.
• W2023238933 hasAuthorship W2023238933A5074071806 @default.
• W2023238933 hasAuthorship W2023238933A5079975386 @default.
• W2023238933 hasBestOaLocation W20232389331 @default.
• W2023238933 hasConcept C136834591 @default.
• W2023238933 hasConcept C161879069 @default.
• W2023238933 hasConcept C169760540 @default.
• W2023238933 hasConcept C185592680 @default.
• W2023238933 hasConcept C201750760 @default.
• W2023238933 hasConcept C2776985911 @default.
• W2023238933 hasConcept C2777738006 @default.
• W2023238933 hasConcept C2778609137 @default.
• W2023238933 hasConcept C2779055221 @default.
• W2023238933 hasConcept C28328180 @default.
• W2023238933 hasConcept C529278444 @default.
• W2023238933 hasConcept C62478195 @default.
• W2023238933 hasConcept C86803240 @default.
• W2023238933 hasConcept C95444343 @default.
• W2023238933 hasConceptScore W2023238933C136834591 @default.
• W2023238933 hasConceptScore W2023238933C161879069 @default.
• W2023238933 hasConceptScore W2023238933C169760540 @default.
• W2023238933 hasConceptScore W2023238933C185592680 @default.
• W2023238933 hasConceptScore W2023238933C201750760 @default.
• W2023238933 hasConceptScore W2023238933C2776985911 @default.
• W2023238933 hasConceptScore W2023238933C2777738006 @default.
• W2023238933 hasConceptScore W2023238933C2778609137 @default.
• W2023238933 hasConceptScore W2023238933C2779055221 @default.
• W2023238933 hasConceptScore W2023238933C28328180 @default.
• W2023238933 hasConceptScore W2023238933C529278444 @default.
• W2023238933 hasConceptScore W2023238933C62478195 @default.
• W2023238933 hasConceptScore W2023238933C86803240 @default.
• W2023238933 hasConceptScore W2023238933C95444343 @default.
• W2023238933 hasFunder F4320320912 @default.
• W2023238933 hasFunder F4320335125 @default.
• W2023238933 hasIssue "3" @default.
• W2023238933 hasLocation W20232389331 @default.

• next