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- W2023239713 abstract "Human adenovirus (HAd)-based vectors are notorious for their ability to induce profound innate immune responses, causing liver damage and even lethal circulatory collapse. In a recent issue of Science, Doronin et al.1 now show that one of the ways by which adenoviruses trigger the innate immune response is through the binding of coagulation factor X (FX), a phylogenetically ancient component of the blood clotting system. Interference with this process may therefore make adenoviral vectors both safer and more effective." @default.
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- W2023239713 date "2012-12-01" @default.
- W2023239713 modified "2023-09-25" @default.
- W2023239713 title "Adenovirus Immunity: X Marks the Spot" @default.
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- W2023239713 doi "https://doi.org/10.1038/mt.2012.240" @default.
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