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• W2023242353 abstract "Novel silybin acylated derivatives with dicarboxylic acids were prepared in various organic solvents using immobilized Candida antarctica lipase B (Novozym 435(®)). The reaction parameters affecting the silybin conversion, such as the nature of the organic solvent and the acyl donor used were investigated. The antiproliferative effects of silybin monoesters, and their ability to modulate the secretion of vascular endothelial growth factor (VEGF) were estimated using K562 human lymphoblastoma cells and compared to the parental compound. The synthesized esters retained the biological function of silybin and in some cases were more effective, indicating that target biotransformation may generate novel compounds with improved antitumor and antiangiogenic activities." @default.
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• W2023242353 date "2011-07-01" @default.
• W2023242353 modified "2023-09-26" @default.
• W2023242353 title "Biocatalytic synthesis and antitumor activities of novel silybin acylated derivatives with dicarboxylic acids" @default.
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• W2023242353 doi "https://doi.org/10.1016/j.nbt.2011.01.006" @default.
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