FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2023242803> ?p ?o ?g. }

• W2023242803 endingPage "195" @default.
• W2023242803 startingPage "184" @default.
• W2023242803 abstract "GABAA receptors are targets of highly chlorinated environmental chemicals and have important roles in developing neurons. As such, we examined effects of polychlorinated biphenyls (PCBs) on GABAA receptor responses in primary cultures of rat neocortical cells using fluorescence imaging techniques. Between days in vitro (DIV) 5 and 8, the effect of GABAA receptor stimulation switched from excitatory (Ca2+ entry following a Cl− efflux; DIV ≤6) to inhibitory (Cl− influx without a Ca2+ rise; DIV ≥7). GABAA-receptor-stimulated increases in [Ca2+]i were diminished in a concentration-dependent (1–20 μM) manner following 1 h of exposure to the PCB mixture Aroclor 1254 (A1254), with significant reductions at concentrations as low as 2 μM. A1254 (1–20 μM) also led to concentration-dependent increases in basal [Ca2+]i, irrespective of DIV. A1254 (10 and 20 μM) significantly increased basal Ca2+i; the Ca2+i was elevated to 426 ± 39 nM by 20 μM A1254 but this concentration was not cytotoxic at 1 h. In addition, the mixture, A1254, as well as ortho- and non-ortho-chlorinated PCB congeners (IUPAC Nos. 4, 15, 126, and 138; 5–10 μM) individually decreased GABAA-stimulated Ca2+i responses and this tended not to depend on increases in basal Ca2+i. In cultures DIV 7 and older, A1254 (20 μM) also impaired inhibitory GABAA responses as evidenced by an ∼50% reduction of GABAA-stimulated Cl− influx (from ∼6 to 8 mM net accumulation in controls). The results demonstrate that: (1) GABAA receptor increases in Ca2+i and Cl−i are inhibited by 2–20 μM A1254, regardless of whether the responses are at excitatory or inhibitory stages of development; (2) Ca2+i homeostasis in cortical cells is disrupted by 10 μM A1254; yet (3) disruption of excitatory GABAA responses by A1254 or PCB congeners does not necessarily depend on impaired Ca2+ homeostasis. These novel observations suggest that GABAA receptor responses are a sensitive target for PCB effects in the rat developing nervous system." @default.
• W2023242803 created "2016-06-24" @default.
• W2023242803 creator A5026833249 @default.
• W2023242803 creator A5051896168 @default.
• W2023242803 date "2000-04-01" @default.
• W2023242803 modified "2023-10-17" @default.
• W2023242803 title "Perturbation by the PCB Mixture Aroclor 1254 of GABAA Receptor-Mediated Calcium and Chloride Responses during Maturation in Vitro of Rat Neocortical Cells" @default.
• W2023242803 cites W1509410836 @default.
• W2023242803 cites W1549243184 @default.
• W2023242803 cites W1705218924 @default.
• W2023242803 cites W1856380311 @default.
• W2023242803 cites W1964842209 @default.
• W2023242803 cites W1965474945 @default.
• W2023242803 cites W1965730980 @default.
• W2023242803 cites W1966243944 @default.
• W2023242803 cites W1967475203 @default.
• W2023242803 cites W1968590543 @default.
• W2023242803 cites W1972059737 @default.
• W2023242803 cites W1972516199 @default.
• W2023242803 cites W1973108213 @default.
• W2023242803 cites W1975003944 @default.
• W2023242803 cites W1990614791 @default.
• W2023242803 cites W1994056327 @default.
• W2023242803 cites W1997303320 @default.
• W2023242803 cites W2001605191 @default.
• W2023242803 cites W2001941168 @default.
• W2023242803 cites W2003403763 @default.
• W2023242803 cites W2005245481 @default.
• W2023242803 cites W2010009395 @default.
• W2023242803 cites W2010152255 @default.
• W2023242803 cites W2015667498 @default.
• W2023242803 cites W2016026611 @default.
• W2023242803 cites W2023647995 @default.
• W2023242803 cites W2025256394 @default.
• W2023242803 cites W2035289053 @default.
• W2023242803 cites W2036359153 @default.
• W2023242803 cites W2038134987 @default.
• W2023242803 cites W2042004387 @default.
• W2023242803 cites W2042463748 @default.
• W2023242803 cites W2045445445 @default.
• W2023242803 cites W2052896972 @default.
• W2023242803 cites W2052989086 @default.
• W2023242803 cites W2057132228 @default.
• W2023242803 cites W2065346737 @default.
• W2023242803 cites W2076907968 @default.
• W2023242803 cites W2077570701 @default.
• W2023242803 cites W2077780274 @default.
• W2023242803 cites W2081189848 @default.
• W2023242803 cites W2083007471 @default.
• W2023242803 cites W2086138574 @default.
• W2023242803 cites W2091720000 @default.
• W2023242803 cites W2095405363 @default.
• W2023242803 cites W2106452927 @default.
• W2023242803 cites W2111909451 @default.
• W2023242803 cites W2139582126 @default.
• W2023242803 cites W2140170366 @default.
• W2023242803 cites W2141260882 @default.
• W2023242803 cites W2147937519 @default.
• W2023242803 cites W2330340734 @default.
• W2023242803 cites W3023285107 @default.
• W2023242803 doi "https://doi.org/10.1006/taap.2000.8898" @default.
• W2023242803 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/10764632" @default.
• W2023242803 hasPublicationYear "2000" @default.
• W2023242803 type Work @default.
• W2023242803 sameAs 2023242803 @default.
• W2023242803 citedByCount "29" @default.
• W2023242803 countsByYear W20232428032013 @default.
• W2023242803 countsByYear W20232428032014 @default.
• W2023242803 countsByYear W20232428032017 @default.
• W2023242803 countsByYear W20232428032018 @default.
• W2023242803 crossrefType "journal-article" @default.
• W2023242803 hasAuthorship W2023242803A5026833249 @default.
• W2023242803 hasAuthorship W2023242803A5051896168 @default.
• W2023242803 hasBestOaLocation W20232428031 @default.
• W2023242803 hasConcept C112592302 @default.
• W2023242803 hasConcept C12554922 @default.
• W2023242803 hasConcept C126322002 @default.
• W2023242803 hasConcept C134018914 @default.
• W2023242803 hasConcept C168258287 @default.
• W2023242803 hasConcept C170493617 @default.
• W2023242803 hasConcept C17077164 @default.
• W2023242803 hasConcept C185592680 @default.
• W2023242803 hasConcept C24998067 @default.
• W2023242803 hasConcept C519063684 @default.
• W2023242803 hasConcept C55493867 @default.
• W2023242803 hasConcept C71924100 @default.
• W2023242803 hasConcept C86803240 @default.
• W2023242803 hasConceptScore W2023242803C112592302 @default.
• W2023242803 hasConceptScore W2023242803C12554922 @default.
• W2023242803 hasConceptScore W2023242803C126322002 @default.
• W2023242803 hasConceptScore W2023242803C134018914 @default.
• W2023242803 hasConceptScore W2023242803C168258287 @default.
• W2023242803 hasConceptScore W2023242803C170493617 @default.
• W2023242803 hasConceptScore W2023242803C17077164 @default.
• W2023242803 hasConceptScore W2023242803C185592680 @default.
• W2023242803 hasConceptScore W2023242803C24998067 @default.
• W2023242803 hasConceptScore W2023242803C519063684 @default.
• W2023242803 hasConceptScore W2023242803C55493867 @default.

• next