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• W2023243467 abstract "Objective: The morphology of human pronuclear embryos has been positively correlated to blastocyst development and implantation and therefore may be useful in achieving high clinical pregnancy rates while limiting the risk of high-order multiple gestations. Pronuclear scores have been shown to be both independent of maternal age and infertility diagnosis, further enhancing their prognostic value. The purpose of this study was to further define the predictive independence of pronuclear scoring by determining its relationship with maternal age and day 3 FSH.Design: Retrospective study of 326 consecutive ART cycles in a university-affiliated ART program.Materials/Methods: All patients undergoing ART from January to December 2000 were considered for analysis. Pronuclear scoring, maternal age, and serum day 3 FSH data were available for 282 cycles. Day 3 FSH results were obtained within one year of the start of the ART cycle. Patients with values ≥12 IU/L or age ≥43 years were excluded. Pronuclear scoring was performed the day following oocyte retrieval and insemination. Pronuclear embryos were scored as Z1, Z2, Z3, or Z4 based on nuclear size and alignment, and number and distribution of nucleoli as previously described (Scott et al., 2000). Distribution of high-grade pronuclear embryos (Z1 and Z2) was then compared with maternal age and day 3 FSH. Statistical evaluation was performed by regression analysis.Results: A total of 2548 pronuclear embryos were scored as Z1 (n = 893), Z2 (n = 854), Z3 (n = 542), or Z4 (n = 259). A scatter plot of the percentage of Z1 and Z2 pronuclear embryos versus maternal age demonstrated no apparent correlation. Similar results were obtained when high-grade pronuclear embryos were compared with day 3 FSH values. Regression analysis confirmed the lack of correlation of Z1 and Z2 pronuclear embryos with maternal age (R2 = 0.009) and day 3 FSH (R2 < 0.001).Conclusions: When performed in a group of patients undergoing ART, pronuclear scoring did not correlate with either maternal age or day 3 FSH serum levels. This observation indirectly supports the conclusion that pronuclear scoring may be a useful tool to predict outcome at ART, since the Z-score was independent of two variables that strongly influence ART outcome. Objective: The morphology of human pronuclear embryos has been positively correlated to blastocyst development and implantation and therefore may be useful in achieving high clinical pregnancy rates while limiting the risk of high-order multiple gestations. Pronuclear scores have been shown to be both independent of maternal age and infertility diagnosis, further enhancing their prognostic value. The purpose of this study was to further define the predictive independence of pronuclear scoring by determining its relationship with maternal age and day 3 FSH. Design: Retrospective study of 326 consecutive ART cycles in a university-affiliated ART program. Materials/Methods: All patients undergoing ART from January to December 2000 were considered for analysis. Pronuclear scoring, maternal age, and serum day 3 FSH data were available for 282 cycles. Day 3 FSH results were obtained within one year of the start of the ART cycle. Patients with values ≥12 IU/L or age ≥43 years were excluded. Pronuclear scoring was performed the day following oocyte retrieval and insemination. Pronuclear embryos were scored as Z1, Z2, Z3, or Z4 based on nuclear size and alignment, and number and distribution of nucleoli as previously described (Scott et al., 2000). Distribution of high-grade pronuclear embryos (Z1 and Z2) was then compared with maternal age and day 3 FSH. Statistical evaluation was performed by regression analysis. Results: A total of 2548 pronuclear embryos were scored as Z1 (n = 893), Z2 (n = 854), Z3 (n = 542), or Z4 (n = 259). A scatter plot of the percentage of Z1 and Z2 pronuclear embryos versus maternal age demonstrated no apparent correlation. Similar results were obtained when high-grade pronuclear embryos were compared with day 3 FSH values. Regression analysis confirmed the lack of correlation of Z1 and Z2 pronuclear embryos with maternal age (R2 = 0.009) and day 3 FSH (R2 < 0.001). Conclusions: When performed in a group of patients undergoing ART, pronuclear scoring did not correlate with either maternal age or day 3 FSH serum levels. This observation indirectly supports the conclusion that pronuclear scoring may be a useful tool to predict outcome at ART, since the Z-score was independent of two variables that strongly influence ART outcome." @default.
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• W2023243467 date "2001-09-01" @default.
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• W2023243467 title "Human pronuclear morphology is independent of maternal age and day 3 FSH in assisted reproductive technology (ART)." @default.
• W2023243467 doi "https://doi.org/10.1016/s0015-0282(01)02809-6" @default.
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