Matches in SemOpenAlex for { <https://semopenalex.org/work/W2023243778> ?p ?o ?g. }
- W2023243778 endingPage "470" @default.
- W2023243778 startingPage "463" @default.
- W2023243778 abstract "Abstract Tyrosinase plays various roles in organisms and much research has focused on the regulation of tyrosinase activity. We studied the inhibitory effect of thiobarbituric acid (TBA) on tyro- sinase. Our kinetic study showed that TBA inhibited tyrosinase in a reversible noncompetitive manner (K i = 14.0 ± 8.5 mM and IC50 = 8.0 ± 1.0 mM). Intrinsic and ANS-binding fluorescences studies were also performed to gain more information regarding the binding mechanism. The results showed that no tertiary structural changes were obviously observed. For further insight, we predicted the 3D structure of tyrosinase and simulated the docking between tyrosinase and TBA. The docking simulation was successful with significant scores (binding energy for AutoDock4:—5.52 kcal/mol) and suggested that TBA was located in the active site. The 11 ns molecular dynamics simulation convinced that the four HIS residues (residue numbers: 57, 90, 250, and 282) were commonly responsible for the interaction with TBA. Our results provide a new inhibition strategy that works using an antioxidant rather than targeting the copper ions within the tyrosinase active site." @default.
- W2023243778 created "2016-06-24" @default.
- W2023243778 creator A5002413587 @default.
- W2023243778 creator A5002739553 @default.
- W2023243778 creator A5004382884 @default.
- W2023243778 creator A5015031536 @default.
- W2023243778 creator A5030041708 @default.
- W2023243778 creator A5031718263 @default.
- W2023243778 creator A5036940497 @default.
- W2023243778 creator A5064504666 @default.
- W2023243778 creator A5068253582 @default.
- W2023243778 creator A5076992782 @default.
- W2023243778 creator A5091244669 @default.
- W2023243778 date "2011-12-01" @default.
- W2023243778 modified "2023-09-23" @default.
- W2023243778 title "The Effect of Thiobarbituric Acid on Tyrosinase: Inhibition Kinetics and Computational Simulation" @default.
- W2023243778 cites W1964047219 @default.
- W2023243778 cites W1972557284 @default.
- W2023243778 cites W1974602517 @default.
- W2023243778 cites W1974781567 @default.
- W2023243778 cites W1979502772 @default.
- W2023243778 cites W1986334743 @default.
- W2023243778 cites W1996716971 @default.
- W2023243778 cites W2008820668 @default.
- W2023243778 cites W2010019633 @default.
- W2023243778 cites W2010068810 @default.
- W2023243778 cites W2016331364 @default.
- W2023243778 cites W2021520922 @default.
- W2023243778 cites W2023379972 @default.
- W2023243778 cites W2024156915 @default.
- W2023243778 cites W2027208202 @default.
- W2023243778 cites W2030352819 @default.
- W2023243778 cites W2043742955 @default.
- W2023243778 cites W2056657581 @default.
- W2023243778 cites W2058844545 @default.
- W2023243778 cites W2063207851 @default.
- W2023243778 cites W2087427054 @default.
- W2023243778 cites W2095256839 @default.
- W2023243778 cites W2102517829 @default.
- W2023243778 cites W2107317356 @default.
- W2023243778 cites W2132262459 @default.
- W2023243778 cites W2139041513 @default.
- W2023243778 cites W2143464311 @default.
- W2023243778 cites W2152301430 @default.
- W2023243778 cites W2152825159 @default.
- W2023243778 cites W2165526004 @default.
- W2023243778 cites W2165541184 @default.
- W2023243778 cites W2167245897 @default.
- W2023243778 cites W2175870498 @default.
- W2023243778 cites W2332282186 @default.
- W2023243778 doi "https://doi.org/10.1080/07391102.2011.10507398" @default.
- W2023243778 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/22066533" @default.
- W2023243778 hasPublicationYear "2011" @default.
- W2023243778 type Work @default.
- W2023243778 sameAs 2023243778 @default.
- W2023243778 citedByCount "22" @default.
- W2023243778 countsByYear W20232437782012 @default.
- W2023243778 countsByYear W20232437782013 @default.
- W2023243778 countsByYear W20232437782014 @default.
- W2023243778 countsByYear W20232437782015 @default.
- W2023243778 countsByYear W20232437782016 @default.
- W2023243778 countsByYear W20232437782017 @default.
- W2023243778 countsByYear W20232437782018 @default.
- W2023243778 countsByYear W20232437782019 @default.
- W2023243778 countsByYear W20232437782023 @default.
- W2023243778 crossrefType "journal-article" @default.
- W2023243778 hasAuthorship W2023243778A5002413587 @default.
- W2023243778 hasAuthorship W2023243778A5002739553 @default.
- W2023243778 hasAuthorship W2023243778A5004382884 @default.
- W2023243778 hasAuthorship W2023243778A5015031536 @default.
- W2023243778 hasAuthorship W2023243778A5030041708 @default.
- W2023243778 hasAuthorship W2023243778A5031718263 @default.
- W2023243778 hasAuthorship W2023243778A5036940497 @default.
- W2023243778 hasAuthorship W2023243778A5064504666 @default.
- W2023243778 hasAuthorship W2023243778A5068253582 @default.
- W2023243778 hasAuthorship W2023243778A5076992782 @default.
- W2023243778 hasAuthorship W2023243778A5091244669 @default.
- W2023243778 hasConcept C121332964 @default.
- W2023243778 hasConcept C148898269 @default.
- W2023243778 hasConcept C159110408 @default.
- W2023243778 hasConcept C181199279 @default.
- W2023243778 hasConcept C185592680 @default.
- W2023243778 hasConcept C202751555 @default.
- W2023243778 hasConcept C2777504301 @default.
- W2023243778 hasConcept C2777752497 @default.
- W2023243778 hasConcept C2778004101 @default.
- W2023243778 hasConcept C2780829032 @default.
- W2023243778 hasConcept C2781338088 @default.
- W2023243778 hasConcept C41183919 @default.
- W2023243778 hasConcept C41685203 @default.
- W2023243778 hasConcept C55493867 @default.
- W2023243778 hasConcept C62520636 @default.
- W2023243778 hasConcept C71240020 @default.
- W2023243778 hasConcept C71924100 @default.
- W2023243778 hasConcept C87554066 @default.
- W2023243778 hasConceptScore W2023243778C121332964 @default.
- W2023243778 hasConceptScore W2023243778C148898269 @default.
- W2023243778 hasConceptScore W2023243778C159110408 @default.