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• W2023244004 startingPage "e772" @default.
• W2023244004 abstract "Chronic pain due to osteoarthritis (OA) can lead to significant disruption of sleep and increased restlessness. Our objective was to assess whether naturally occurring canine OA is associated with nighttime restlessness and so has potential as a model of OA-associated sleep disturbance. The study was designed as a two-part prospective masked, placebo-controlled study using client-owned dogs (Part A n = 60; Part B n = 19). Inclusion criteria consisted of OA-associated joint pain and mobility impairment. The primary outcome measure for both parts was nighttime accelerometry. In Part B, quality of sleep was assessed using a clinical metrology instrument (Sleep and Night Time Restlessness Evaluation Score, SNoRE). Part A included dogs receiving two weeks of non-steroidal anti-inflammatory drug (NSAID) preceded with two weeks of no treatment. Part B was a crossover study, with NSAID/placebo administered for two weeks followed by a washout period of one week and another two weeks of NSAID/placebo. Repeated measures analysis of variance was used to assess differences between baseline and treatment. There were no significant changes in accelerometry-measured nighttime activity as a result of NSAID administration. SNoRE measures indicated significant improvements in aspects of the quality of nighttime sleep that did not involve obvious movement. These results reflect the few similar studies in human OA patients. Although accelerometry does not appear to be useful, this model has potential to model the human pain-related nighttime sleep disturbance, and other outcome measures should be explored in this model." @default.
• W2023244004 created "2016-06-24" @default.
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• W2023244004 date "2015-02-17" @default.
• W2023244004 modified "2023-10-14" @default.
• W2023244004 title "Initial evaluation of nighttime restlessness in a naturally occurring canine model of osteoarthritis pain" @default.
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• W2023244004 doi "https://doi.org/10.7717/peerj.772" @default.
• W2023244004 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/4340376" @default.
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