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• W2023244011 abstract "The liver is known to induce tolerance rather than immunity through tolerogenic antigen presentation or elimination of effector T cells. In particular, hepatic dendritic cells (DC) are known to be little immunogenic for CD8 T cells. Here, we investigated whether this peculiar phenotype resulted from interaction with resident hepatic cell populations. Contact of DC with liver sinusoidal endothelial cells (LSEC) but not hepatocytes or B cells vetoed antigen-presenting DC to fully activate naive CD8 T cells. This MHC-independent regulatory effect of LSEC on DC function was not connected to soluble mediators but required physical contact. Because interaction with third-party LSEC still allowed antigen-presenting DC to stimulate expression of initial activation markers on naive CD8 T cells and to stimulate activated CD8 T cells, we hypothesize that LSEC controlled the DC costimulatory function. Indeed, contact with LSEC led to reduced DC expression levels of CD80/86 or IL-12, but supplementation of these signals failed to rescue the ability to prime naive CD8 T cells, indicating involvement of further molecules. Taken together, our results reveal a novel principle operative in hepatic tolerance induction, in which LSEC not only tolerize T cells themselves but also suppress neighboring APC normally capable of inducing T cell immunity." @default.
• W2023244011 created "2016-06-24" @default.
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• W2023244011 date "2008-04-01" @default.
• W2023244011 modified "2023-10-15" @default.
• W2023244011 title "Liver sinusoidal endothelial cells veto CD8 T cell activation by antigen-presenting dendritic cells" @default.
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• W2023244011 doi "https://doi.org/10.1002/eji.200738060" @default.
• W2023244011 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/18383043" @default.
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