Matches in SemOpenAlex for { <https://semopenalex.org/work/W2023245574> ?p ?o ?g. }
- W2023245574 endingPage "132" @default.
- W2023245574 startingPage "125" @default.
- W2023245574 abstract "Tumor necrosis factor alpha (TNFalpha) is a pleiotropic cytokine with several CNS physiological and pathophysiological actions including sleep, memory, thermal and appetite regulation. Short interfering RNAs (siRNA) targeting TNFalpha were incubated with cortical cell cultures and microinjected into the primary somatosensory cortex (SSctx) of rats. The TNFalpha siRNA treatment specifically reduced TNFalpha mRNA by 45% in vitro without affecting interleukin-6 or gluR1-4 mRNA levels. In vivo the TNFalpha siRNAalpha reduced TNFalpha mRNA, interleukin-6 mRNA and gluR1 mRNA levels compared to treatment with a scrambled control siRNA. After in vivo microinjection, the density of TNFalpha-immunoreactive cells in layer V of the SSctx was also reduced. Electroencephalogram (EEG) delta wave power was decreased on days 2 and 3 on the side of the brain that received the TNFalpha siRNA microinjection relative to the side receiving the control siRNA. These findings support the hypothesis that TNFalpha siRNA attenuates TNFalpha mRNA and TNFalpha protein in the rat cortex and that those reductions reduce cortical EEG delta power. Results also are consistent with the notion that TNFalpha is involved in CNS physiology including sleep regulation." @default.
- W2023245574 created "2016-06-24" @default.
- W2023245574 creator A5017954767 @default.
- W2023245574 creator A5025249477 @default.
- W2023245574 creator A5027897528 @default.
- W2023245574 creator A5036211359 @default.
- W2023245574 creator A5037968675 @default.
- W2023245574 creator A5047314367 @default.
- W2023245574 creator A5048174460 @default.
- W2023245574 creator A5062630573 @default.
- W2023245574 creator A5073749050 @default.
- W2023245574 creator A5076327240 @default.
- W2023245574 date "2007-07-01" @default.
- W2023245574 modified "2023-09-27" @default.
- W2023245574 title "TNFα siRNA reduces brain TNF and EEG delta wave activity in rats" @default.
- W2023245574 cites W1491105838 @default.
- W2023245574 cites W1548862642 @default.
- W2023245574 cites W1563952748 @default.
- W2023245574 cites W1611419331 @default.
- W2023245574 cites W1647075334 @default.
- W2023245574 cites W1891629407 @default.
- W2023245574 cites W1892340976 @default.
- W2023245574 cites W1895907979 @default.
- W2023245574 cites W1905939990 @default.
- W2023245574 cites W1926095516 @default.
- W2023245574 cites W1973171009 @default.
- W2023245574 cites W1977144770 @default.
- W2023245574 cites W1978523938 @default.
- W2023245574 cites W1980758580 @default.
- W2023245574 cites W1985879298 @default.
- W2023245574 cites W2010523730 @default.
- W2023245574 cites W2011633356 @default.
- W2023245574 cites W2012547585 @default.
- W2023245574 cites W201343304 @default.
- W2023245574 cites W2013906894 @default.
- W2023245574 cites W2020287085 @default.
- W2023245574 cites W2023178743 @default.
- W2023245574 cites W2047275854 @default.
- W2023245574 cites W2048468809 @default.
- W2023245574 cites W2064559284 @default.
- W2023245574 cites W2064805929 @default.
- W2023245574 cites W2068249996 @default.
- W2023245574 cites W2069665324 @default.
- W2023245574 cites W2072209360 @default.
- W2023245574 cites W2072846584 @default.
- W2023245574 cites W2083921126 @default.
- W2023245574 cites W2085559812 @default.
- W2023245574 cites W2086679559 @default.
- W2023245574 cites W2110385304 @default.
- W2023245574 cites W2114956093 @default.
- W2023245574 cites W2118624908 @default.
- W2023245574 cites W2119581672 @default.
- W2023245574 cites W2125664352 @default.
- W2023245574 cites W2130765148 @default.
- W2023245574 cites W2150857556 @default.
- W2023245574 cites W2173973727 @default.
- W2023245574 cites W2197774836 @default.
- W2023245574 cites W2399025129 @default.
- W2023245574 cites W2428527983 @default.
- W2023245574 cites W4238300309 @default.
- W2023245574 cites W4292956939 @default.
- W2023245574 cites W74621134 @default.
- W2023245574 doi "https://doi.org/10.1016/j.brainres.2007.04.072" @default.
- W2023245574 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/2041959" @default.
- W2023245574 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/17531209" @default.
- W2023245574 hasPublicationYear "2007" @default.
- W2023245574 type Work @default.
- W2023245574 sameAs 2023245574 @default.
- W2023245574 citedByCount "50" @default.
- W2023245574 countsByYear W20232455742012 @default.
- W2023245574 countsByYear W20232455742013 @default.
- W2023245574 countsByYear W20232455742014 @default.
- W2023245574 countsByYear W20232455742015 @default.
- W2023245574 countsByYear W20232455742016 @default.
- W2023245574 countsByYear W20232455742017 @default.
- W2023245574 countsByYear W20232455742018 @default.
- W2023245574 countsByYear W20232455742019 @default.
- W2023245574 countsByYear W20232455742020 @default.
- W2023245574 countsByYear W20232455742021 @default.
- W2023245574 countsByYear W20232455742022 @default.
- W2023245574 crossrefType "journal-article" @default.
- W2023245574 hasAuthorship W2023245574A5017954767 @default.
- W2023245574 hasAuthorship W2023245574A5025249477 @default.
- W2023245574 hasAuthorship W2023245574A5027897528 @default.
- W2023245574 hasAuthorship W2023245574A5036211359 @default.
- W2023245574 hasAuthorship W2023245574A5037968675 @default.
- W2023245574 hasAuthorship W2023245574A5047314367 @default.
- W2023245574 hasAuthorship W2023245574A5048174460 @default.
- W2023245574 hasAuthorship W2023245574A5062630573 @default.
- W2023245574 hasAuthorship W2023245574A5073749050 @default.
- W2023245574 hasAuthorship W2023245574A5076327240 @default.
- W2023245574 hasBestOaLocation W20232455742 @default.
- W2023245574 hasConcept C104317684 @default.
- W2023245574 hasConcept C105580179 @default.
- W2023245574 hasConcept C126322002 @default.
- W2023245574 hasConcept C134018914 @default.
- W2023245574 hasConcept C150903083 @default.
- W2023245574 hasConcept C169760540 @default.