Matches in SemOpenAlex for { <https://semopenalex.org/work/W2023245875> ?p ?o ?g. }
- W2023245875 endingPage "296" @default.
- W2023245875 startingPage "279" @default.
- W2023245875 abstract "Alphaviruses are positive-stranded RNA viruses that have a broad host range and therefore are capable of replicating in many vertebrate and invertebrate cells. The single-stranded alphavirus genome is divided into two ORFs. The first ORF encodes the nonstructural proteins that are translated upon entry of the virus into the cytoplasm and are responsible for transcription and replication of viral RNA. The second ORF is under the control of a subgenomic promoter and normally encodes the structural proteins, which are responsible for encapsidation of viral RNA and final assembly into enveloped particles. Expression vectors have been engineered from at least three alphaviruses in which the structural protein gene region has been replaced by heterologous genes and have been shown to express high levels of the heterologous protein in cultured cells. These RNA vectors, known as replicons, are capable of replicating on their own but are not packaged into virus-like particles unless the structural proteins are provided in trans. Thus, replicons are single cycle vectors incapable of spreading from infected to noninfected cells. Because of these features, alphavirus replicon vectors are being developed as a platform vaccine technology for numerous viral, bacterial, protozoan and tumour antigens where they have been shown to be efficient inducers of both humoral and T cell responses. In addition, as the alphavirus structural proteins are not expressed in vaccine recipients, antivector immune responses are generally minimal, allowing for multiple effective immunisations of the same individual. Copyright © 2002 John Wiley & Sons, Ltd." @default.
- W2023245875 created "2016-06-24" @default.
- W2023245875 creator A5037385666 @default.
- W2023245875 creator A5065452416 @default.
- W2023245875 creator A5083648491 @default.
- W2023245875 date "2002-01-01" @default.
- W2023245875 modified "2023-10-06" @default.
- W2023245875 title "Alphavirus vectors and vaccination" @default.
- W2023245875 cites W1504170631 @default.
- W2023245875 cites W1509422165 @default.
- W2023245875 cites W1535836957 @default.
- W2023245875 cites W1544830913 @default.
- W2023245875 cites W1560019489 @default.
- W2023245875 cites W1566730797 @default.
- W2023245875 cites W1568604491 @default.
- W2023245875 cites W1592948339 @default.
- W2023245875 cites W1602528206 @default.
- W2023245875 cites W1607452994 @default.
- W2023245875 cites W1657414671 @default.
- W2023245875 cites W1667933161 @default.
- W2023245875 cites W1678182324 @default.
- W2023245875 cites W1716707690 @default.
- W2023245875 cites W1735561674 @default.
- W2023245875 cites W1792529763 @default.
- W2023245875 cites W1815651224 @default.
- W2023245875 cites W1833364882 @default.
- W2023245875 cites W1897775719 @default.
- W2023245875 cites W1902051377 @default.
- W2023245875 cites W1921346031 @default.
- W2023245875 cites W1921832335 @default.
- W2023245875 cites W1925135733 @default.
- W2023245875 cites W1964922162 @default.
- W2023245875 cites W1966055810 @default.
- W2023245875 cites W1969631838 @default.
- W2023245875 cites W1969673444 @default.
- W2023245875 cites W1969949759 @default.
- W2023245875 cites W1970136118 @default.
- W2023245875 cites W1973606344 @default.
- W2023245875 cites W1973742536 @default.
- W2023245875 cites W1975836300 @default.
- W2023245875 cites W1976443173 @default.
- W2023245875 cites W1986094246 @default.
- W2023245875 cites W1987144538 @default.
- W2023245875 cites W1988136894 @default.
- W2023245875 cites W1991079881 @default.
- W2023245875 cites W1992509322 @default.
- W2023245875 cites W1992514603 @default.
- W2023245875 cites W1995886571 @default.
- W2023245875 cites W1997992792 @default.
- W2023245875 cites W1998495837 @default.
- W2023245875 cites W1998667730 @default.
- W2023245875 cites W2002064064 @default.
- W2023245875 cites W2006168695 @default.
- W2023245875 cites W2012251384 @default.
- W2023245875 cites W2012978577 @default.
- W2023245875 cites W2013414439 @default.
- W2023245875 cites W2014578259 @default.
- W2023245875 cites W2017836050 @default.
- W2023245875 cites W2017919672 @default.
- W2023245875 cites W2019729662 @default.
- W2023245875 cites W2021015803 @default.
- W2023245875 cites W2023309406 @default.
- W2023245875 cites W2023670709 @default.
- W2023245875 cites W2024067415 @default.
- W2023245875 cites W2024161219 @default.
- W2023245875 cites W2026260520 @default.
- W2023245875 cites W2026478950 @default.
- W2023245875 cites W2026641742 @default.
- W2023245875 cites W2028339539 @default.
- W2023245875 cites W2031584609 @default.
- W2023245875 cites W2036090735 @default.
- W2023245875 cites W2039291991 @default.
- W2023245875 cites W2039664761 @default.
- W2023245875 cites W2039869767 @default.
- W2023245875 cites W2040712691 @default.
- W2023245875 cites W2041402370 @default.
- W2023245875 cites W2042249918 @default.
- W2023245875 cites W2043875683 @default.
- W2023245875 cites W2048064261 @default.
- W2023245875 cites W2049227607 @default.
- W2023245875 cites W2050723214 @default.
- W2023245875 cites W2050922197 @default.
- W2023245875 cites W2051473632 @default.
- W2023245875 cites W2051688782 @default.
- W2023245875 cites W2052505961 @default.
- W2023245875 cites W2053111306 @default.
- W2023245875 cites W2054579301 @default.
- W2023245875 cites W2055047899 @default.
- W2023245875 cites W2057626486 @default.
- W2023245875 cites W2057978785 @default.
- W2023245875 cites W2059551093 @default.
- W2023245875 cites W2063756352 @default.
- W2023245875 cites W2064091819 @default.
- W2023245875 cites W2065769226 @default.
- W2023245875 cites W2066127249 @default.
- W2023245875 cites W2069915263 @default.
- W2023245875 cites W2070919514 @default.
- W2023245875 cites W2073742945 @default.