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- W2023246212 abstract "It is not surprising that the recent explosion of interest in physiological cell death has been centered particularly on lymphocytes. Physiological cell death responses are singularly important in the biology of T lymphocytes, especially in the establishment and maintenance of a diverse, non-autoreactive, and self-limiting repertoire. Cell death responses can be triggered in T cells by a variety of stimuli; sensitivity to these inducers is altered as a function of differentiation, activation, aging, and transformation. The elimination of autoreactive T cells occurs by a process that involves comitogenic stimulation at high dose with antigenic and/or mitogenic agents. The control of susceptibility to this activation-driven cell death with differentiation and with prior activation provides a mechanistic explanation for the development of central and peripheral tolerance. Enhanced lymphocyte activation with aging also leads to an augmented activation-driven cell death response. However, aging does not alter cell death responses generally, and aging-associated changes in cell death responses cannot account for aging-associated immunopathology. Oncogenic transformation also alters the activation-driven cell death response by supplanting one of the required signals for activation-driven cell death. This difference provides a rationale for selective anti-tumor therapy. A single mechanism underlies all cases of physiological cell death and involves out-of-phase mitotic activity. We now know that of the two hallmarks of cell death, genome digestion is dispensable and mitotic-like events associated with cell cycle arrest are critical. T cells triggered to undergo physiological cell death arrest in a post-mitotic compartment of the cell cycle and die when they attempt a precocious and abortive mitosis." @default.
- W2023246212 created "2016-06-24" @default.
- W2023246212 creator A5048740334 @default.
- W2023246212 creator A5053820618 @default.
- W2023246212 creator A5066699811 @default.
- W2023246212 creator A5070776223 @default.
- W2023246212 date "1994-12-01" @default.
- W2023246212 modified "2023-10-14" @default.
- W2023246212 title "Physiological T-Cell Death: Susceptibility is Modulated by Activation, Aging, and Transformation, but the Mechanism is Constant" @default.
- W2023246212 cites W14542710 @default.
- W2023246212 cites W1505469822 @default.
- W2023246212 cites W1516581843 @default.
- W2023246212 cites W1538805645 @default.
- W2023246212 cites W1542795408 @default.
- W2023246212 cites W1546128691 @default.
- W2023246212 cites W1548138662 @default.
- W2023246212 cites W1552751328 @default.
- W2023246212 cites W1566217027 @default.
- W2023246212 cites W1572448432 @default.
- W2023246212 cites W1589415602 @default.
- W2023246212 cites W1594989289 @default.
- W2023246212 cites W1599940306 @default.
- W2023246212 cites W1606548047 @default.
- W2023246212 cites W1607475594 @default.
- W2023246212 cites W167981432 @default.
- W2023246212 cites W1795102356 @default.
- W2023246212 cites W1890612314 @default.
- W2023246212 cites W1898775203 @default.
- W2023246212 cites W1916442090 @default.
- W2023246212 cites W1925019465 @default.
- W2023246212 cites W1934463538 @default.
- W2023246212 cites W1959677146 @default.
- W2023246212 cites W1965268115 @default.
- W2023246212 cites W1967071341 @default.
- W2023246212 cites W1970456090 @default.
- W2023246212 cites W1970825176 @default.
- W2023246212 cites W1971245466 @default.
- W2023246212 cites W1972354503 @default.
- W2023246212 cites W1973435955 @default.
- W2023246212 cites W1976340479 @default.
- W2023246212 cites W1977299280 @default.
- W2023246212 cites W1978045062 @default.
- W2023246212 cites W1978164779 @default.
- W2023246212 cites W1980655244 @default.
- W2023246212 cites W1981589551 @default.
- W2023246212 cites W1983201658 @default.
- W2023246212 cites W1984695968 @default.
- W2023246212 cites W1986356667 @default.
- W2023246212 cites W1989600187 @default.
- W2023246212 cites W1991101546 @default.
- W2023246212 cites W1991476335 @default.
- W2023246212 cites W1995069145 @default.
- W2023246212 cites W1996116228 @default.
- W2023246212 cites W1999218524 @default.
- W2023246212 cites W2000042748 @default.
- W2023246212 cites W2001256186 @default.
- W2023246212 cites W2003403462 @default.
- W2023246212 cites W2003501749 @default.
- W2023246212 cites W2004275733 @default.
- W2023246212 cites W2007854325 @default.
- W2023246212 cites W2009389356 @default.
- W2023246212 cites W2009428230 @default.
- W2023246212 cites W2009946316 @default.
- W2023246212 cites W2010714905 @default.
- W2023246212 cites W2011501168 @default.
- W2023246212 cites W2011787986 @default.
- W2023246212 cites W2012062569 @default.
- W2023246212 cites W2013026773 @default.
- W2023246212 cites W2014445311 @default.
- W2023246212 cites W2015150670 @default.
- W2023246212 cites W2016168521 @default.
- W2023246212 cites W2017185316 @default.
- W2023246212 cites W2017424140 @default.
- W2023246212 cites W2017728731 @default.
- W2023246212 cites W2019918282 @default.
- W2023246212 cites W2022847127 @default.
- W2023246212 cites W2023053069 @default.
- W2023246212 cites W2023536598 @default.
- W2023246212 cites W2025332550 @default.
- W2023246212 cites W2025535815 @default.
- W2023246212 cites W2026891958 @default.
- W2023246212 cites W2028111124 @default.
- W2023246212 cites W2029372789 @default.
- W2023246212 cites W2030183133 @default.
- W2023246212 cites W2032428064 @default.
- W2023246212 cites W2032592355 @default.
- W2023246212 cites W2033360952 @default.
- W2023246212 cites W2034401615 @default.
- W2023246212 cites W2036368914 @default.
- W2023246212 cites W2036419095 @default.
- W2023246212 cites W2036817346 @default.
- W2023246212 cites W2038231022 @default.
- W2023246212 cites W2038340312 @default.
- W2023246212 cites W2039132486 @default.
- W2023246212 cites W2040063578 @default.
- W2023246212 cites W2043066069 @default.
- W2023246212 cites W2043360335 @default.
- W2023246212 cites W2046279172 @default.