FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2023247416> ?p ?o ?g. }

• W2023247416 abstract "Male infertility has become a worldwide health problem, but the etiologies of most cases are still unknown. SEPT12, a GTP-binding protein, is involved in male fertility. Two SEPT12 mutations (SEPT12T89M and SEPT12D197N) have been identified in infertile men who had a defective sperm annulus with a bent tail. The function of SEPT12 in the sperm annulus is still unclear. Here, we found that SEPT12 formed a filamentous structure with SEPT7, 6, 2 and 4 at the sperm annulus. The SEPT12-based septin core complex was assembled as SEPT12-7-6-2-2-6-7-12 or SEPT12-7-6-4-4-6-7-12 octameric filaments. In addition, the GTP-binding domain of SEPT12 was critical for its interaction with SEPT7, and the NC-terminus of SEPT12 was required for the interaction of SEPT12 with itself to polymerize octamers into filaments. Mutant mice carrying the SEPT12D197N mutation, which disrupts SEPT12 filament formation, showed a disorganized sperm annulus, bent tail, reduced motility and loss of the SEPT ring structure at the sperm annulus. These phenotypes were also observed in an infertile man carrying SEPT12D197N. Taken together, our results demonstrate the molecular architecture of septin12 filaments at the sperm annulus, their mechanical support of sperm motility, and their correlation with male infertility." @default.
• W2023247416 created "2016-06-24" @default.
• W2023247416 creator A5005102249 @default.
• W2023247416 creator A5018453639 @default.
• W2023247416 creator A5018776288 @default.
• W2023247416 creator A5020722581 @default.
• W2023247416 creator A5021894753 @default.
• W2023247416 creator A5051889064 @default.
• W2023247416 creator A5084321349 @default.
• W2023247416 creator A5086454498 @default.
• W2023247416 date "2015-01-01" @default.
• W2023247416 modified "2023-10-18" @default.
• W2023247416 title "SEPT12 orchestrates the formation of mammalian sperm annulus by organizing SEPT12-7-6-2/-4 core complexes" @default.
• W2023247416 cites W1591032344 @default.
• W2023247416 cites W1965649202 @default.
• W2023247416 cites W1982486389 @default.
• W2023247416 cites W1988476536 @default.
• W2023247416 cites W1993728115 @default.
• W2023247416 cites W1994842913 @default.
• W2023247416 cites W2003629016 @default.
• W2023247416 cites W2008200554 @default.
• W2023247416 cites W2014190140 @default.
• W2023247416 cites W2022371219 @default.
• W2023247416 cites W2037399479 @default.
• W2023247416 cites W2060501484 @default.
• W2023247416 cites W2070520948 @default.
• W2023247416 cites W2078116784 @default.
• W2023247416 cites W2088190945 @default.
• W2023247416 cites W2091168806 @default.
• W2023247416 cites W2102732162 @default.
• W2023247416 cites W2119005065 @default.
• W2023247416 cites W2120129786 @default.
• W2023247416 cites W2140240207 @default.
• W2023247416 cites W2146632337 @default.
• W2023247416 cites W2148567371 @default.
• W2023247416 cites W2151464048 @default.
• W2023247416 cites W2168306046 @default.
• W2023247416 cites W34264966 @default.
• W2023247416 doi "https://doi.org/10.1242/jcs.158998" @default.
• W2023247416 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/25588830" @default.
• W2023247416 hasPublicationYear "2015" @default.
• W2023247416 type Work @default.
• W2023247416 sameAs 2023247416 @default.
• W2023247416 citedByCount "50" @default.
• W2023247416 countsByYear W20232474162015 @default.
• W2023247416 countsByYear W20232474162016 @default.
• W2023247416 countsByYear W20232474162017 @default.
• W2023247416 countsByYear W20232474162018 @default.
• W2023247416 countsByYear W20232474162019 @default.
• W2023247416 countsByYear W20232474162020 @default.
• W2023247416 countsByYear W20232474162021 @default.
• W2023247416 countsByYear W20232474162022 @default.
• W2023247416 countsByYear W20232474162023 @default.
• W2023247416 crossrefType "journal-article" @default.
• W2023247416 hasAuthorship W2023247416A5005102249 @default.
• W2023247416 hasAuthorship W2023247416A5018453639 @default.
• W2023247416 hasAuthorship W2023247416A5018776288 @default.
• W2023247416 hasAuthorship W2023247416A5020722581 @default.
• W2023247416 hasAuthorship W2023247416A5021894753 @default.
• W2023247416 hasAuthorship W2023247416A5051889064 @default.
• W2023247416 hasAuthorship W2023247416A5084321349 @default.
• W2023247416 hasAuthorship W2023247416A5086454498 @default.
• W2023247416 hasBestOaLocation W20232474161 @default.
• W2023247416 hasConcept C104317684 @default.
• W2023247416 hasConcept C143065580 @default.
• W2023247416 hasConcept C150936888 @default.
• W2023247416 hasConcept C2777338322 @default.
• W2023247416 hasConcept C2777632594 @default.
• W2023247416 hasConcept C2777688143 @default.
• W2023247416 hasConcept C2779234561 @default.
• W2023247416 hasConcept C2781087480 @default.
• W2023247416 hasConcept C54355233 @default.
• W2023247416 hasConcept C58207958 @default.
• W2023247416 hasConcept C59822182 @default.
• W2023247416 hasConcept C86803240 @default.
• W2023247416 hasConcept C95444343 @default.
• W2023247416 hasConceptScore W2023247416C104317684 @default.
• W2023247416 hasConceptScore W2023247416C143065580 @default.
• W2023247416 hasConceptScore W2023247416C150936888 @default.
• W2023247416 hasConceptScore W2023247416C2777338322 @default.
• W2023247416 hasConceptScore W2023247416C2777632594 @default.
• W2023247416 hasConceptScore W2023247416C2777688143 @default.
• W2023247416 hasConceptScore W2023247416C2779234561 @default.
• W2023247416 hasConceptScore W2023247416C2781087480 @default.
• W2023247416 hasConceptScore W2023247416C54355233 @default.
• W2023247416 hasConceptScore W2023247416C58207958 @default.
• W2023247416 hasConceptScore W2023247416C59822182 @default.
• W2023247416 hasConceptScore W2023247416C86803240 @default.
• W2023247416 hasConceptScore W2023247416C95444343 @default.
• W2023247416 hasLocation W20232474161 @default.
• W2023247416 hasLocation W20232474162 @default.
• W2023247416 hasOpenAccess W2023247416 @default.
• W2023247416 hasPrimaryLocation W20232474161 @default.
• W2023247416 hasRelatedWork W1996923643 @default.
• W2023247416 hasRelatedWork W2019759732 @default.
• W2023247416 hasRelatedWork W2164870966 @default.
• W2023247416 hasRelatedWork W2359881245 @default.
• W2023247416 hasRelatedWork W2387154909 @default.
• W2023247416 hasRelatedWork W2790457967 @default.
• W2023247416 hasRelatedWork W2949959833 @default.

• next